Principles of opioid pharmacotherapy: Practical implications of basic mechanisms

Journal of Pain and Symptom Management

Volumn 11, Issue 5, 1996, Pages 265-273

  Ferrante, F Michael ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

opioids; oral administration; pain management; parenteral administration; Pharmacotherapy

Indexed keywords

CODEINE; FENTANYL; HYDROMORPHONE; LEVORPHANOL; METHADONE; MORPHINE; OPIATE; OPIATE AGONIST; OXYCODONE; PETHIDINE;

ARTICLE; DROWSINESS; DRUG DEPENDENCE; DRUG POTENCY; HUMAN; ILEUS; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PAIN; PAIN ASSESSMENT; RESPIRATION DEPRESSION; STRUCTURE ACTIVITY RELATION;

EID: 0029944494     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/0885-3924(95)00201-4     Document Type: Article

References (64)

1. Ferrante FM. Opioids. In: Ferrante FM, Vade-Boncoeur TR, eds. Postoperative pain management. New York: Churchill-Livingstone, 1993:145-209.
2. Thorpe DH. Opiate structure and activity: a guide to understanding the receptor. Anesth Analg 1984;63:143-151.
3. Fields HL. Central nervous system mechanisms for control of pain transmission. New York: McGraw-Hill, 1987:99-131.
4. Beckett AH, Casey AF. Synthetic analgesics, stereochemical considerations. J Pharm Pharmacol 1954;6:986-991.
5. 3H] Sufentanil, a superior ligand for u opiate receptors: binding properties and regional distribution in rat brain and spinal cord. Eur J Pharmacol 1983;87: 209-225.
6. Kosterlitz WH. Opiate actions in guinea pig ileum and mouse vas deferens. Neurosci Res Bull 1975;13:68-70.
7. Martin WR, Eades CG, Thompson JA, et al. The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent cyclazocine-dependent spinal dog. J Pharmacol Exp Ther 1976;197:517-532.
8. Gilbert PE, Martin WR. The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 1976;198:66-82.
9. Maze M. Clinical implications of membrane receptor function in anesthesia. Anesthesiology 1981;55:160-171.
10. Vaught JL, Rothman RB, Westfall TC. μ and δ receptors: their role in analgesia and in the differential effects of opioid peptides on analgesia. Life Sci 1982;30:1443-1455.
11. Pasternak GW, Wood PJ. Multiple μ opiate receptors. Life Sci 1986;38:1889-1898.
12. Pasternak GW. Multiple morphine and enkephalin receptors and the relief of pain. JAMA 1988;259:1362-1367.
13. Goodman RR, Snyder SH, Kuhar MJ, Young WS III. Differentiation of 6 and u opiate receptor localizations by light microscopic autoradiography. Proc Natl Acad Sci USA 1988;77:6239-6243.
14. Duka T, Schubert P, Wuster M, Stoiber R, Herz A. A selective distribution pattern of different opiate receptors in certain areas of rat brain as revealed by in vitro autoradiography. Neurosci Lett 1981;21:119-124.
15. Quirion R, Zajac JM, Morgat JL, Roques BP. Autoradiographic distribution of μ and δ opiate receptors in rat brain using highly selective ligands. Life Sci 1983;33 (suppl 1):227-230.
16. Wood PL, Richard JW, Thakur M. μ-opiate isoreceptors: differentiation with K agonists. Life Sci 1982;31:2313-2317.
17. Pasternak GW, Childers SR, Snyder SH. Opiate analgesia: evidence for mediation by a subpopulation of opiate receptors. Science 1980;208:514-516.
18. 1 sites. Mol Pharmacol 1984;25:29-37.
19. Yaksh TL. Analgesic actions of intrathecal opiates in cat and primate. Brain Res 1978;153:205-210.
20. Yaksh TL. In vivo studies on spinal opiate receptor systems mediating antinociception: I. μ and δ receptor profiles in the primate. J Pharmacol Exp Ther 1983;226:303-316.
21. Yaksh TL, Huang SP, Rudy TA. The direct and specific opiate-like effect of met 5-enkephalin and analogs on the spinal cord. Neuroscience 1977;2: 593-596.
22. 5] enkephalin in cancer patients with chronic pain. Pain 1985;23:213-221.
23. Martin WR. Opioid antagonists. Pharmacol Rev 1967;19:463-521.
24. Hameroff SR. Opiate receptor pharmacology: mixed agonist-antagonist narcotics. Contemp Anesth Pract 1983;7:27-31.
25. Frey E. Opioid agonists, antagonists and mixed narcotic analgesics: theoretical background and considerations for practical use. Berlin: Springer-Verlag, 1987.
26. Schmidt WK, Tam SW, Shortzberger GS, Smith DH Jr, Clark R, Vernier VG. Nalbuphine. Drug Alcohol Depend 1985;14:339-352.
27. Foley KM. The treatment of cancer pain. N Engl J Med 1985;313:84-95.
28. Twycross RG, McQuay HJ. Opioids. In: Wall PD, Melzack R, eds. Textbook of pain, 2nd ed. Edinburgh: Livingstone, 1989:686-701.
29. Houde RW, Wallenstein SL, Beaver WT. Evaluation of analgesics in patients with cancer pain. In: Lasagna L, eds. International encyclopedia of pharmacology and therapeutics, vol 1. New York: Pergamon, 1966;59-65.
30. Inturrisi CE, Foley KM. Narcotic analgesics in the management of pain. In: Kuhar M, Pasternak G, eds. Analgesics: neurochemical, behavioral and clinical perspectives. New York: Raven, 1984;251-259.
31. Sawe J, Dahlström B, Paalzow L, Rane A. Morphine kinetics in cancer patients. Clin Pharmacol Ther 1981;30:629.
32. Routledge PA, Shand DG. Presystemic drug elimination. Annu Rev Pharmacol Toxicol 1979;19: 447-468.
33. Houde RW, Wallenstein SL, Beaver WT. Clinical measurement of pain. In: de Stevens G, ed. Analgesics. New York: Academic, 1975:75-81.
34. Twycross RG. The use of narcotic analgesics in terminal illness. J Med Ethics 1975;1:10-17.
35. Kaiko RF. Discussion. In: Foley K, Inturrisi CE, eds. Advances in pain research and therapy, vol 8. New York, Raven, 1986:235.
36. Urquhart ML, Klapp K, White PF. Patient-controlled analgesia: a comparison of intravenous versus subcutaneous hydromorphone. Anesthesiology 1988;69:428.
37. Mueller RA, Lundberg DB, Breese GR, Hedner J, Hedner T, Jonason J. The neuropharmacy of respiratory control. Pharmacol Rev 1982;34:255-285.
38. Martin WR. Pharmacology of opioids. Pharmacol Rev 1967;35:283-323.
39. BellvilleJW, Seed JC. The effect of drugs on the respiratory response to carbon dioxide. Anesthesiology 1960;21:727-737.
40. Eckenhoff JE, Oech SR. The effects of narcotics and antagonists upon respiration and circulation in man. Clin Pharmacol Ther 1960;1:483-489.
41. Jaffe JH, Martine WR. Opioid analgesics and antagonists. In: Gilman AG, Goodman LS, Rall TW, Murad F, eds. The pharmacological basis of therapeutics, 7th ed. New York: MacMillan, 1985:491-531.
42. Kitahata LM, Collins JG, Robinson CJ. Narcotic effects on the nervous system. In: Kitahata LM, Collins JG, eds. Narcotic analgesics in anesthesiology. Baltimore: William and Wilkins, 1982:57-65.
43. Murphy MR, Hug CC Jr. The enflurane sparing effect of morphine, butorphanol and nalbuphine. Anesthesiology 1982;57;489-492.
44. Frey E. The various effects caused by opioids. In: Opioid agonists, antagonists and mixed narcotic analgesics: theoretical background and considerations for practical use. Berlin: Springer-Verlag, 1987:27-53.
45. World Health Organization. Expert committee on drug dependence, 16th report. Technical report series no. 407. Geneva: World Health Organization, 1969.
46. Porter J, Jick J. Addiction is rare in patients treated with narcotics [Letter]. N Engl J Med 1980; 302:123.
47. Burks TF. Gastrointestinal pharmacology. Annu Rev Pharmacol Toxicol 1976;16:15-31.
48. Porreca F, Burks TF. The spinal cord as a site of opioid effects on gastrointestinal transit in the mouse. J Pharmacol Exp Ther 1983;227:22-27.
49. McCammon RL, Stoelting RK, Madura JA. Effects of butorphanol, nalbuphine, and fentanyl on intrabiliary tract dynamics. Anesth Analg 1984; 63:139-142.
50. Humphreys HK, Fleming NW. Opioid-induced spasm of the sphincter of Oddi apparently reversed by nalbuphine. Anesth Analg 1992;74:308-310.
51. Reitan JA, Stengert KB, Wymore MC, Martucci W. Central vagal control of fentanyl-induced bradycardia during halothane anesthesia. Anesth Analg 1978;57:31-36.
52. Laubie M, Schmitt H, Vincent M. Vagal bradycardia produced by microinjections of morphine-like drugs into the nucleus ambiguus in anesthetized dogs. Eur J Pharmacol 1979;59:287-291.
53. 2O in the dog. Anesth Analg 1976;55:168-172.
54. Strauer BE. Contractile responses to morphine, piritramide, meperidine and fentanyl: a comparative study of effects on the isolated ventricular myocardium. Anesthesiology 1972;37:304-310.
55. Freye E. Cardiovascular effects of high doses of fentanyl, meperidine and naloxone in dogs. Anesth Analg 1974;53:40-47.
56. Barash P, Kopriva C, Giles R. Global ventricular function and intubation: radionuclear profiles, abstracted. Anesthesiology 1980;53:A109.
57. Golberg AH, Padget CH. Comparative effects of morphine and fentanyl on isolated heart muscle. Anesth Analg 1969;48:978-982.
58. Lowenstein E, Whiting RB, Bittar DA, Sanders CA, Powell WJ Jr. Local and neurally mediated effects of morphine on skeletal muscle vascular resistance. J Pharmacol Exp Ther 1972;180:359-367.
59. Ward JM, McGrath RL, Weil JV. Effects of morphine on the peripheral vascular response to sympathetic stimulation. Am J Cardiol 1972;29:659-666.
60. Roscow CE, Moss I, Philbin DM, Savarese JJ. Histamine release during morphine and fentanyl anesthesia. Anesthesiology 1982;56:93-96.
61. Flacke JW, Flack WE, Boor BC, Van Etten AP, Kripke BJ. Histamine release by four narcotics: a double-blind study in humans. Anesth Analg 1987; 66:723-730.
62. Murphy MR, Hug CC Jr. Pharmacokinetics of intravenous morphine in patients anesthetized with enflurane-nitrous oxide. Anesthesiology 1981;54: 187-192.
63. Wood M. Opioid agonists and antagonists. In: Wood M, Wood AJJ, eds. Drugs and anesthesia: pharmacology for anesthesiologists. Baltimore: William and Wilkins, 1990:129-178.
64. Stoelting RK. Opioid agonists and antagonists. In: Stoelting RK. Pharmacology and physiology in anesthetic practice. Philadelphia: Lippincott, 1987: 69-101.