Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2′-deoxyuridine 5′-monophosphate

Biochemistry

Volumn 35, Issue 13, 1996, Pages 3944-3949

  Costi, Paola M ^a   Liu, Lu ^b   Finer Moore, Janet S ^b   Stroud, Robert M ^b   Santi, Daniel V ^b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYURIDINE PHOSPHATE; THYMIDYLATE SYNTHASE;

ARTICLE; ENZYME ACTIVITY; ENZYME STRUCTURE; HYDROGEN BOND; METHYLATION; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ASPARAGINE; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONSERVED SEQUENCE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DEOXYURACIL NUCLEOTIDES; HYDROGEN BONDING; KINETICS; LACTOBACILLUS CASEI; METHYLATION; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THYMIDYLATE SYNTHASE;

EID: 0029943822     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi952642i     Document Type: Article

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