Medication use in seniors: Challenges and solutions;Traitement utilise chez les sujets ages: Defis et solutions

Therapie

Volumn 51, Issue 3, 1996, Pages 269-282

  Tamblyn, R ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

elderly patients; medication

Indexed keywords

ANXIOLYTIC AGENT; HYPNOTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; CLINICAL PROTOCOL; CONGESTIVE HEART FAILURE; DRUG EFFICACY; DRUG INFORMATION; DRUG SAFETY; ELECTROLYTE DISTURBANCE; FALLING; GERIATRIC CARE; HEALTH CARE POLICY; HEALTH CARE QUALITY; HUMAN; HYPOTENSION; PRIORITY JOURNAL; SIDE EFFECT; TREATMENT PLANNING;

AGED; AGED, 80 AND OVER; DELIVERY OF HEALTH CARE; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; DRUG UTILIZATION; HEALTH CARE COSTS; HEALTH POLICY; HUMANS; MORBIDITY; PRESCRIPTIONS, DRUG; RISK FACTORS; SELF MEDICATION;

EID: 0029943340     PISSN: 00405957     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (186)

1. Williams P, Rush DR. Geriatric polypharmacy. Hosp Prac 1986; 21: 109-120.
2. Belaud F. Patterns of health and social services utilization. Can J Aging 1989; 8: 19-33.
3. Health and welfare Canada. Canada Health Survey author No 82-538E, 1981.
4. Carruthers G, Goldberg T, Segal H, Sellers E. Drug utilization: a comprehensive literature review. Department of Health Administration, University of Toronto 1979.
5. Health and Welfare Canada. National health expenditures in Canada 1975; 1985.
6. Service de l'évaluation des programmes et des statistiques de la Régie. Statistiques Annuelles 1992. 22nd ed. Québec: Régie de l'assurance-maladie du Québec, ISSN 0226-5346, 1992: 1-303.
7. Tamblyn RM, McLeod PJ, Abrahamowicz M, Laprise R. Do too many cooks spoil the broth? Multiple physician involvement in medical management and inappropriate prescribing in the elderly. Can Med Assoc J 1995 (in press).
8. Tamblyn RM, McLeod P, Abrahamowicz M et al. Questionable prescribing for elderly patients in Quebec. Can Med Assoc J 1994; 150: 1801-1809.
9. Sova G. 1989 Corpus Almanac and Canadian Sourcebook. Vol. 1: Don Mills, Ont: Corpus Information Services, 1989.
10. Larochelle P, Bass MJ, Birkett NJ, De Champlain J, Myers MG. Recommendations from the Consensus Conference on Hypertension in the Elderly. Can Med Assoc J 1986; 135: 741-745.
11. Roch DJ, Evans RG, Pascoe DW. Winnipeg: Manitoba Health Services Commission. Manitoba and Medicare: 1971 to the Present 1985.
12. National pharmaceutical strategy discussion document. The National Pharmaceutical Strategy Office, Drugs Directorate, Health Protection Branch 1993.
13. Grymonpre RE, Mitenko PA, Sitar DS, Aoki FY, Montgomery PR. Drug-associated hospital admissions in older medical patients. J Am Geriatr Soc 1988; 36: 1092-1098.
14. Ives TJ, Bentz EJ, Gwyther RE. Drug-related admissions to a family medicine inpatient service. Arch Intern Med 1987; 147: 1117-1120.
15. Hurwitz N. Predisposing factors in adverse reactions to drugs. BMJ 1969; i: 536-539.
16. May FE, Stewart RB, Cluff LE. Drug intercations and multiple drug administration. Clin Pharmarol Ther 1977; 22: 322.
17. Mulroy R. Iatrogenic disease in general practice: its incidence and effects. BMJ 1973; ii: 407-410.
18. Hutchinson TA, Flegal KM, Kramer MS, Leduc DG, Ho Ping Kong H. Frequency, severity and risk factors for adverse drug reactions in adult outpatients: a prospective study. J Chron Dis 1986; 39: 533-542.
19. Karch FE, Lasagna L. Adverse drug reactions: a critical review. JAMA 1975; 234: 1236-1241.
20. Smidt WA, McQueen EG. Adverse reactions to drugs: a comprehensive inpatient survey. NZ Med J 1972; 76: 397.
21. Lumley LE, Walker SR, Hall CG et al. The underreporting of adverse drug reactions seen in general practice. Pharm Med 1986; 1: 205.
22. Nolan L, O'Malley K. Prescribing for the elderly part 1: Sensitivity of the elderly to adverse drug reactions. J Am Geriatr Soc 1988; 36: 142-149.
23. Klein LE, German PS, Levine DM. Adverse drug reactions among the elderly: a reassessment. J Am Geriatr Soc 1981; 29: 525-530.
24. Gurwitz JH, Avorn J. The ambiguous relation between aging and adverse drug reactions. Ann Intern Med 1991; 114: 956-966.
25. Colt HG, Shapiro AP. Drug-induced illness as a cause for admission to a community hospital. J Am Geriatr Soc 1989; 37: 323-326.
26. Caranosos GJ, Stewart RB, Cuff LE. Drug-induced illness leading to hospitalization. JAMA 1974; 228: 713-717.
27. Taggart HMcA. Do drugs affect the risk of hip fractures in elderly women? J Am Geriatr Soc 1988; 36: 1006-1010.
28. Sloan RW. Alternative first line therapies in geriatric hypertension. Geriatrics 1989; 44: 61-74.
29. Goodwin JS, Regan M. Cognitive dysfunction associated with naproxen and ibuprofen in the elderly. Arthritis Rheumatism 1982; 25: 1013-1015.
30. Bigelow W, Collins T. Impact of nonsteriodal antiinflammatory agents on general gastrointestinal upset in an elderly population. In: Edlevitch SA, ed. Pharmacoepidemiology: Volume 1. Chelsea, Michigan: Lewis Pub. Inc., 1989: 243.
31. Neuberger JS, Neuberger GB. Epidemiology of rheumatic diseases. Nurs Clin North Am 1984; 19: 713.
32. Buechler JR, Malloy W. Drug therapy in the elderly: how to achieve optimum results. Postgrad Med 1989; 85: 87-99.
33. Miller RR. Hospital admissions due to adverse drug reactions, a report from the Boston collaborative drug surveillance program. Arch Intern Med 1974; 134: 219-223.
34. Larson EB, Kukull WA, Buchner D, Reifler BV. Adverse drug reactions associated with global cognitive impairment in elderly persons. Ann Intern Med 1987; 107: 169-173.
35. MacDonald JB, MacDonald ET. Nocturnal femoral fracture and continuing widespread use of barbituate hypnotics. BMJ 1977; ii: 483-485.
36. Tinneti ME, Speechley M, Ginter S. Risk factors for falls among elderly persons living in the community. N Engl J Med 1988; 319: 1701.
37. Ray WA, Griffin MR, Schaffner W, Baugh DK, Melton LJ. Psychotropic drug use and the risk of hip fracture. N Engl J Med 1987; 316: 363-369.
38. Hallas J, Gram LF, Grodum E et al. Drug related admissions to medical wards: a population based survey. Br J Clin Pharmacol 1992; 33: 61-68.
39. Hallas J, Haghfelt T, Gram LF, Grodum E, Damsbo N. Drug related admissions to a cardiology department; frequency and avoidability. J Intern Med 1990; 228: 379-384.
40. Griffin MR, Piper JM, Daugherty JR, Snowden M, Ray WA. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med 1991; 114: 257-263.
41. Gabriel SE, Jaakkimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. Ann Mem Med 1991; 115: 787-796.
42. Fries JF, Miller SR, Spitz PW et al. Identification of patients at risk for gastropathy associated with NSAID use. J Rheumatol 1990; 17 (suppl 20): 12-19.
43. Davis P, Baer PA, Schulz J, Camerlain M. Reducing the risk of NSAID-related complications. Can J Diag 1991; August: 95-101.
44. Fries JF, Miller SR, Spitz PW et al. Towards an epidemiology of gastropathy associated with non-steroidal antiinflammatory drug use. Gastroenterology 1989; 96: 647-655.
45. Menkes CJ. Renal and hepatic effects of NSAIDs in the elderly. Scand J Rheumatol 1989; Suppl. 83: 11-13.
46. Ray MA, Griffin MR, Downey W. Benzodiazepines of long and short elimination half-life and the risk of hip fracture. JAMA 1989; 262: 3303-3307.
47. Stevens A, Mulrow C. Drugs affecting postural stability and other risk factors in the hip fracture epidemic - case-control study. Community Med 1989; 11, No.1: 27-34.
48. Jensen J, Nielsen LH. Drugs and femoral neck fracture: a case-control study. J Intern Med 1991; 229: 29-33.
49. Grisso JA, kelsey JL, Strom BL et al. Risk factors for falls as a cause of hip fracture in women. N Engl J Med 1991; 324: 1326-1331.
50. Cumming RG, Klineberg RJ. Psychotropics, thiazide diuretics and hip fractures in the elderly. Med J Aust 1993; 158: 414-417.
51. Sorock GS, Shimkin EE. Benzodiazepine sedatives and the risk of falling in a community-dwelling elderly cohort. Arch Intern Med 1988; 148: 2441-2444.
52. Ruthazer R, Lipsitz LA. Antidepressants and falls among elderly people in long-term care. Am J Public Health 1993; 83, No. 5: 746-749.
53. Sobel KG, McCart GM. Drug use and accidental falls in an intermediate care facility. Geriatr Gerontol 1983; 17: 539-545.
54. Granek B, Baker SP, Abbey H et al. Medications and diagnoses in relation to falls in a long-term care facility. J Am Geriatr Soc 1987; 35(6): 503-511.
55. Mayo N, Korner-Bitensky N, Georges P, Becker R. Predicting falls among patients in a rehabilitation hospital. Am J Phys Med Rehabil 1989; 16: 139-146.
56. Mayo N, Korner-Bitensky N, Kaizer F. Relationship between response-time and falls among stroke patients undergoing physical rehabilitation. Int J Rehab Res 1990; 13: 47-55.
57. Mayo N, Levy AR, Korner-Bitensky N. Risk factors for fractures due to falls. Arch Phys Med Rehabil 1993; 74: 917-921.
58. Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. N Engl J Med 1988; 319: 1701-1707.
59. Larson EB, Kukull WA, Buchner D, Reifler BV. Adverse drug reactions associated with global cognitive impairment in elderly persons. Ann Intern Med 1987; 107: 169-173.
60. Rivara FP, Mueller BA, Fligner CL et al. Drug use in trauma victims. J Trauma 1989; 29, No.4: 462-470.
61. Tamblyn RM, Lavoie G, Petrella L, Monette J. The use of prescription claims databases in pharmacoepidemiological research: the accuracy and comprehensiveness of the prescription claims database in Quebec. J Clin Epidemiol 1995; 48: 999-1009.
62. Cusson J, Pepler C, Tousignant P et al. Drug utilization related problems in elderly Canadians. Ontario: Canadian coalition on medication use and the elderly, 1990: 1-87.
63. Wells KB, Kamberg C, Brook R, Camp P, Rogers W. Health Status, sociodemographic factors, and the use of prescribed psychotropic drugs. Med Care 1985; 23: 1295-1306.
64. King MB. Is there still a role for benzodiazepines in general practice? Br J Gen Prac 1992; 42: 202-205.
65. Lennard H, Cooperstock R. The social context and functions of tranquilizer prescribing. In: Mapes R, ed. Prescribing practice and drug usage. London: Groom Helm, 1980: 73-82.
66. Bradley CP. Uncomfortable prescribing decisions: a critical incident study. BMJ 1992; 304: 294-296.
67. Powell C. Prescribing for the elderly. Medicine North America 1986; 1: 118-133.
68. Cox DR. Regression models and life tables (with Discussion). J R Stat Soc 1972; 34: 187-208.
69. Zucker D, Karr AF. Nonparametric survival analysis with time-dependent covariate effects: a penalized partial likelihood approach. Ann Stat 1990; 18: 329-353.
70. Abrahamowicz M, MacKenzie T, Esdaile J. Time-dependent hazard ratio: modelling and hypothesis testing with application in lupus nephritis. J Am Stat Assoc (in press).
71. Côté R, Battista RN, Abrahamowicz M, Langlois Y, Bourque F, Mackey A and the Asymptomatic Cervical Bruit Study Group. Lack of effect of aspirin in asymptomatic patients with carotid bruits and substantial carotid narrowing. Ann Intern Med 1995; 123: 649-655.
72. Ramsay JO. Monotone regression splines in action (with discussion). Statistical Science 1988; 3: 425-461.
73. Ciampi A. Generalized regression trees. Computational Statistics and Data Analysis 1991; 12: 57-78.
74. Ciampi A, Lou Z, Lin Q, Negassa A. Recursive partition and amalgamation with the exponential family: theory and applications. Applied Stochastic Models and Data Analysis 1991; 7: 121-137.
75. Ciampi A, Dougherty G, Lou Z, Negassa A, Grondin J. NHPPREG: a computer program for the analysis of nonhomogeneous Poisson process data with covariates. Computer Methods & Programs m Biomedicine 1992; 38: 37-48.
76. Ciampi A, Hendricks L, Lou Z. Tree growing for the multivariate model: the RECPAM approach. Compstat '92, Proceeding in Computational aspects of model choice, Physica-Verlag for IASC, Heidelberg 1992; 131-136.
77. Kroencke K. Polypharmacy causes, consequences, and cure. Am J Med 1985; 79: 149.
78. Beers MH, Ouslander JG. Risk factors in geriatric drug prescribing: a practical guide to avoiding problems. Drugs 1989; 37: 1105-112.
79. Beers MH, Storrie M, Lee G. Potential adverse drug interactions in the emergency room: an issue in the quality of care. Ann Intern Med 1990; 112: 61-64.
80. Kendrick R, Bayne JR. Compliance with prescribed medication by elderly patients. Can Med Assoc J 1982; 127: 961.
81. Morrow D, Leirer V, Sheikh J. Adherence and Medication Instructions: Review and Recommendations. J Am Geriatr Soc 1988; 36: 1147-1160.
82. Parkin DM, Henney CR, Quirk J, Crooks J. Deviation from prescribed drug treatment after discharge from hospital. BMJ 1976; ii: 686-688.
83. Gordon M. Principles in prescribing for the older patient. Drug Protocol 1987; 2: 15-24.
84. Harper CM, Newton PA, Walsh JR. Drug-induced illness in the elderly. Postgrad Med 1989; 86: 245-256.
85. Lowenthal DT. Drug therapy in the elderly: special considerations. Geriatrics 1987; 42: 77.
86. Graveley EA, Oseasohn CS. Multiple Drug regimens: medication compliance among veterans 65 years and older. Res Nursing Health 1991; 14: 51-58.
87. Hulka BS, Jupper LL, Cassell JC, Burdette JA. Communication, compliance and concordance between physicians and patients with prescribed medication. Am J Public Health 1976; 66: 847.
88. Kendrick R, Bayne JRD. Compliance with prescibed medication by elderly patients. Can Med Assoc J 1982; 127: 961-962.
89. Wartman SA, Morlock LL, Malitz FE, Palm EA. Patient understanding and satisfaction as predictors of compliance. Med Care 1983; 21: 886-891.
90. Radecki SE, Kane RL, Solomon DH, Mendenhall RC, Beck JC. Do physicians spend less time with older patients? J Am Geriatr Soc 1988; 36: 713-718.
91. Burgess MM. Ethical and economic aspects of noncompliance and overtreatment. Can Med Assoc J 1989; 141: 777-780.
92. Col N, Fanale JE, Kronholm P. The role of medication noncompliance and adverse drug reactions in hospitalizations of the elderly. Arch Intern Med 1990; 150: 841-845.
93. Edwards M, Pathy J. Drug counselling in the elderly and predicting compliance. Practitioner 1984; 228: 291-300.
94. Leirer VO, Morrow DG, Tanke ED, Pariante GM. Elders' nonadherence: its assessment and medication reminding by voice mail. Gerontologist 1991; 31: 514-520.
95. Morrell RW, Park DC, Poon LW. Effects of labeling techniques on memory and comprehension of prescription information in young and old adults. J Gerontol 1990; 45: 166-172.
96. Leirer VO, Morrow DG, Pariante GM, Sheikh JL. Elders' nonadherance: its assessment and computer-assisted instruction for medication recall training. J Am Geriat Soc 1988; 36: 877-884.
97. Isaac LM, Tamblyn RM, and the McGill Calgary Drug Research Team. Compliance and cognitive function: a methodological approach to measuring unintentional errors in medication compliance in the elderly. Gerontologist 1993; 33: 772-781.
98. Folstein MF, Folstein SE, McHugh PR. 'Mini-Mental State' A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
99. Brook RH, Kamberg CJ, Mayer-Oakes A et al. Appropriateness of Acute Medical Care for the Elderly. Santa Monica, Ca.: RAND Corporation 1989: 1-58.
100. Kelson DT, Kiel DP, Anderson JJ, Kannel WB. Alcohol consumption and hip fractures: the framingham study. Am J Epidemiol 1988; 128: 1102-1110.
101. Weyerer S, Dilling H. Psychiatric and physical illness, sociodemographic characteristics, and the use of psychotropic drugs in the community: results from the Upper Bavarian Study. J Clin Epidemiol 1991; 44: 303-311.
102. Raynes NV. Factors affecting the prescribing of psychotropic drugs in general practice consultations. Psychol Med 1979; 9: 671-679.
103. Westerling R. Diagnoses associated with the prescription of psychotropic drugs at a Swedish Health Centre. Stand J Prim Health Care 1988; 6: 93-98.
104. Lindley CM, Tully MP, Paramsothy V, Tallis RC. Inappropriate medication is a major cause of adverse drug reactions in elderly patients. Age Ageing 1992; 21: 294-300.
105. Meyer TJ, Van Kooten D, Marsh S, Prochazka AV. Reduction of polypharmacy by feedback to clinicians. J Gen Intent Med 1991; 6: 133-136.
106. Kroenke K, Pinholt EM. Reducing polypharmacy in the elderly: a controlled trial of physician feedback. J Am Geriatr Soc 1990; 38: 31-36.
107. Kroenke K. Polypharmacy. Causes, consequences, and cure. Am J Med 1985; 79: 149-152.
108. Grymonpre RE, Sitar DS, Montgomery PR, Mitenko PA, Aoki FY. Prescribing patterns for older heavy drug users living in the community. DICP Ann Pharmacother 1991; 25: 186-190.
109. Quinn K, Baker MJ, Evans B. A population-wide profile of prescription drug use in saskatchewan. Can Med Assoc J 1992; 146: 2177-2186.
110. Cafferata GL, Meyers SM. Pathways to psychotropic drugs: understanding the basis of gender differences. Med Care 1990; 28: 285-300.
111. Power B, Downey W, Schnell BR. Utilization of psychotropic drugs in Saskatchewan: 1977-1980. Can J Psychiatry 1983; 28: 547-551.
112. Morabia A, Fabre J, Dunand J-P. The Influence of patient and physician gender on prescription of psychotropic drugs. J Clin Epidemiol 1992; 45: 111-116.
113. Ashton H. Psychotropic-drug prescribing for women. Br J Psychiatry 1991; 158(suppl. 10): 30-35.
114. Verbrugge LM. How physicians treat mentally distressed men and women. Soc Sci Med 1984; 18: 1-9.
115. Seidl LG, Thornton GF, Smith JW, Cluff LE. Studies on the epidemiology of adverse drug reactions III. Reactions in patients on a general medical service. Bull John Hopkins Hosp 1966; 19: 299-315.
116. Bergman U, Wiholm BE. Drug-related problems causing admission to a medical clinic. Eur J Clin Pharmacol 1981; 20: 193-200.
117. Schnarch B, Tamblyn RM, McLeod P et al. Psychotropic drug prescribing in the elderly: Exploration of the patient gender-physician gender relationship. The Canadian Pharmacoepidemiology Forum 1993; Toronto: (abstract)
118. Copperstock R. Sex differences in the use of mood-modifying drugs: an explanatory model. J Health Soc Behav 1971; 12: 238-244.
119. Hohmann AA. Gender bias in psychotropic drug prescribing in primary care. Med Care 1989; 27: 478-490.
120. Cafferata GL, Rasper J, Bernstein A. Family roles, structure, and stressors in relation to sex differences in obtaining psychotropic drugs. J Health Soc Behav 1983; 24(June): 132-143.
121. Van Nostrand JF, Furner SE, Suzman R. Health data on older Americans: United States, 1992. National Center for Health Statistics Vital Health Stat 1993; 3(27).
122. Fiorio R, Bellantuono C, Arreghini E, Leoncini M, Micciolo R. Psychotropic drug prescription in general practice in Italy: a Two-Week Prevalence Study. Int Clin Psychopharmacol 1989; 4: 7-17.
123. Tamblyn RM, Abrahamowicz M, Berkson L et al. The feasibility of using standardized patients to measure the medical management of high risk prescribing situations in the elderly. Final Report, NHRDP Project No. 6605-3752-57P 1993.
124. Angus Reid Group Inc. Medication use in Canadians aged 55 and older: opinions and attitudes, a report to the Canadian Coalition on medication use and the edlerly 1991; November:
125. Slovic P, Kraus N, Lappe H, Major M. Risk perception of prescription drugs: report on a survey in Canada. Can J Public Health 1991; 82: S15-S20.
126. Hartzema AG, Christensen DB. Nonmedical factors associated with the prescribing volume among family practioners in an HMO. Med Care 1983; 21: 990-1000.
127. Davidson W, Malloy W, Somers G, Bédard M. Relationships between physician practice characteristics and prescribing behaviour for the elderly in New Brunswick. Can Med Assoc J 1994; 150: 917.
128. Mokkink H, Smits A, Grol R, Meyboom W, van Son J, University of Nijmegen. Practice performance and quality of care: practice-styles of family physician. Ottawa, Canada: Can-Heal Publications Inc, Book Number 0-921495-01-4, 1990: 305-311.
129. Jennett P, Hogan D, Elford W, Crutcher R, Baumber J. Management of Common Problems in the Elderly. McGill/Calgary Collaborative Study 1994.
130. Davidson W, Malloy W, Bédard M. Physician characteristics and prescribing for elderly people in New Brunswick: relation to patient outcome. Can Med Assoc J 1995; 152 (8): 1227-1234.
131. Bero LA, Lipton HL, Bird JA. Characterization of geriatric drug-related hospital readmissions. Med Care 1991; 29: 989-1003.
132. Bates DW, Leape LL, Petrycki S. Incidence and preventability of adverse drug events in hospitalized adults. J Gen Intern Med 1993; 8: 289-294.
133. Ferguson JA. Patient age as a factor in drug prescribing practices. Can J Aging 1990; 9: 278-295.
134. Kaufman M, Uhlman M. Electronic 2d opinion targets Rxs of ages. The Philadelphia Inquirer 1993; July Section A.
135. Ferry ME, Lamy PP, Becker LA. Physicians' knowledge of prescribing for the elderly. J Am Geriatr Soc 1985; 33: 616-625.
136. Monette J, Tamblyn RM, McLeod P et al. Profile of longacting benzodiazepine drug prescribers. J Clin Invest Med 1993; 16 suppl. 4: B59.
137. Bloom JA, Frank JW, Shafir MS, Martiquet P. Potentially undesirable prescribing and drug use among the elderly; measurable and remediable. Can Fam Physician 1993; 39: 2337-2345.
138. Shorr RI, Bauwens SF, Landefeld CS. Failure to limit quantities of benzodiazepine hypnotic drugs for outpatients: placing the elderly at risk. Am J Med 1990; 89: 725-732.
139. Beers MH, Ouslander JG, Fingold SF et al. Inappropriate medication prescribing in skilled-nursing facilities. Ann Intern Med 1992; 117: 684-689.
140. Svarstad BL, Mount JK. Nursing home resources and tranquilizer use among the institutionalized elderly. J Am Geriat Soc 1991; 39: 869-875.
141. Kearney TE, Manoguerra AS, Curtis GP, Ziegler MG. Theophylline toxicity and the beta-adrenergic system. Ann Intern Med 1985; 102: 766-769.
142. Lombardi TP, Bertino JS, Goldberg A, Middleton E, Slaughter RL. The effects of a beta-2 selective adrenergic agonist and a beta-nonselective antagonist on theophylline clearance. J Clin Pharmacol 1987; 27: 523-529.
143. Corsi C, Nafziger AN, Pieper JA, Bertino J. Lack of effect of atenolol and nadolol on the metabolism of theophylline. Br J Clin Pharmacol 1990; 29: 265-268.
144. Miners JO, Wing MH, Lillywhite KJ, Robson RA. Selectivity and dose-dependency of the inhibitory effect of propranolol on theophylline metabolism in man. Br J Clin Pharmarol 1985; 20: 219-223.
145. Norwalk CT. Basic and clinical pharmacology. 5th edition, London: Appleton-Lange Publishers, 1992.
146. Hansten P, Horn J. Drug interactions. 6th ed. Philadelphia: Lea & Febiger, 1989: 293.
147. Schrier RW. Renal and electrolyte disorders. 4th ed. Boston: Little Brown & Co., 1992.
148. Starr KJ, et al. Drug interactions in patients on long term oral anticoagulant and antihypcrtensive adrenergic neuron-blocking drugs. BMJ 1972; iv: 133.
149. Deckert FW. Ascorbic acid and warfarin. JAMA 1973; 223: 440.
150. O'Reilly R et al. Impact of aspirin and chlorthalidone on the pharmacodynamics of oral anticoagulant drugs in man. Ann N Y Acad Sci 1971; 178: 173.
151. Anon. Aspirin and bleeding. JAMA 1971; 218: 89.
152. O'Brien JR et al. A comparison of an effect of different anti-inflammatory drugs on human platelets. J Clin Pathol 1970; 23: 522.
153. Michot F et al. A double-blind clinical trial to determine if an interaction exists between diclofenac sodium and the oral anticoagulant acenocoumarol (nicoamalone). J Int Med Res 1975; 3: 153.
154. Zucker MB, Peterson J. Effect of acetylsalicylic acid, other nonsteroidal antiinflammatory agents, and dipyridamole on human blood patelets. J Lab Clin Med 1970; 76: 66-75.
155. Fenner H. Nonsteroidal antiinflammatory drugs: benefit/risk evaluation in rheumatic diseases. J Rheumatol 1992; 19: 98-99.
156. Tilstone WJ, Gray JM, Nimme-Smith RH, Lawson DH. Interaction between warfarin and sulphamethoxazole. Postgrad Med J 1977; 53: 388-390.
157. Hochberg, MC. Association of nonsteroidal antiinflammatory drugs with upper gastrointestinal disease: epidemiologic and economic considerations. J Theumatol 1992; 19: 63-67.
158. Melander A, Henricson K, Stenberg P et al. Anxiolytic-hypnotic drugs: Relationships between prescribing, abuse and suicide. Eur J Clin Pharmacol 1991; 41: 525-529.
159. Maronde RF, Lee PV, McCarron MM, Seibert S. A study of prescribing patterns. Med Care 1971; IX: 383-395.
160. Wennberg JE. On patient need, supplier-induced demand, and the need to assess the outcome of common medical problems. Med Care 1985; 23: 512-520.
161. Hemenway D, Fallon D. Testing for physician-induced demand with hypothetical cases. Med Care 1985; 23: 344-349.
162. Mapes R. Prescribing practice and drug usuge. London: Croom Helm, 1980: 9-213.
163. Manning WG, Leibowitz A, Goldberg GA, Rogers WH, Newhouse JP. A controlled trial of the effect of a prepaid group practice on use of service. N Engl J Med 1984; 310: 1505-1510.
164. Newhouse JP, Manning WG, Norris C et al. Some interim results from a controlled trial of cost-sharing in health insurance. N Engl J Med 1981; 305: 1501.
165. Pineault R. The effect of prepaid group practice on physicians' utilization behavior. Med Care 1986; 14: 121.
166. Renaud M, Beuchemin J, Lalonde C et al. Practice settings and prescribing profiles: the simulation of tension headaches to general practioners working in different practice settings in the Montreal area. Am J Public Health 1980; 70: 1068-1073.
167. Sonmerai SB, Avorn J, Ross-Degnan D, Gortmaker S. Payment restrictions for prescription drugs under medicaid: effects on therapy, cost, and equity. N Engl J Med 1987; 317: 550-556.
168. Gillum RF, Barsky AJ. Diagnosis and management of patient noncompliance. JAMA 1974; 228: 1563-1567.
169. Soumerai SB, McLaughlin TJ, Avorn J. Improving drug prescribing in primary care: a critical analysis of the experimental literature. Milbank Q 1989; 67: 268-317.
170. Tamblyn RM, Battista RN. Changing clinical practice: which interventions work? J Cont Educ Health Prof 1993; 13: 273-288.
171. Soumerai SB, Avorn J. Economic and policy analysis of university-based drug 'detailing'. Med Care 1986; 24: 313-331.
172. Johnston ME, Langton DB, Haynes B, Mathieu A. Effects of computer-based clinical decision support systems on clinician performance and patient outcome. Ann Intern Med 1994; 120: 135-142.
173. Grimshaw JM, Russell IT. Effect of clinical guidelines on medical practice: a systematic review of rigorous evaluations. Lancet 1993; 342: 1317-1322.
174. Tatro DS(ed). Drug interaction facts. St. Louis, Missouri: Facts and Comparisons, 1992.
175. Drug newsletter. St-Louis, Missouri: facts and comparisons division, 1993.
176. The Medical Letter Handbook of Adverse Drug Interactions. New York: The Medical Letter Inc. (ISSN 0897-5418), 1993.
177. USDPDI. Drug information for the health care professional by authority of the United States Pharmacopeial Convention, Inc. 1993.
178. Drug facts and comparisons. St-Louis, Missouri: Facts and Comparisons Division, 1993.
179. The Medical Letter. USA: Parkins, CJ. The Medical Letter Inc. (ISSN 0025-732X), 1993.
180. Gurwich EL. Comparison of medication histories acquired by pharmacists and physicians. Am J Hosp Pharm 1983; 40: 1541-1542.
181. Falvo D, Tippy P. Communicating information to patients - patient satisfaction and adherence as associated with resident skill. J Fam Pract 1988; 26: 643-647.
182. Tamblyn RM, Benaroya S, Snell L et al. The feasibility and value of using patient satisfaction ratings to evaluate internal medicine residents. J Gen Intern Med 1994; 9: 146-152.
183. Webster G. American board of internal medicine final report on the patient satisfaction questionnaire project. Philadelphia: ABIM, 1989.
184. Orth JE, Stiles WB, Scherwitz L et al. Patient exposition and provider explanation in routine interviews and hypertensive patients' blood pressure control. Health Psychol 1987; 6: 29-42.
185. Uhlmann RF, Inui TS, Pecoraro RE, Carter WB. Relationship of patient request fulfillment to compliance, glycemic control, and other health care outcomes in insulin-dependent diabetes. J Gen Intern Med 1988; 3: 458-463.
186. Kaplan SH, Greenfield S, Ware JE. Assessing the effects of physician-patient interactions on the outcomes of chronic disease. Med Care 1989; 27 (suppl.): s110-s127.