A mouse mutant strain highly resistant to methyl β-carboline-3-carboxylate-induced seizures

Experimental Brain Research

Volumn 110, Issue 1, 1996, Pages 28-35

  Clément, Yan ^a   Launay, Jean Marie ^b   Bondoux, Dominique ^b   Venault, Patrice ^a   Martin, Benoît ^a   Young, Jacques ^c   Robel, Paul ^c   Chapouthier, Georges ^a  

^a CNRS   (France)

^b BICHAT HOSPITAL   (France)

^c INSERM   (France)

Author keywords

3H flumazenil binding; Methyl carboline 3 carboxylate; Mouse; Neurosteroids; Tabby color; Testicular feminization

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; BENZODIAZEPINE RECEPTOR; BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; CONVULSANT AGENT; STEROID;

ANIMAL EXPERIMENT; ARTICLE; CONVULSION; DRUG BINDING; DRUG EFFECT; DRUG INDUCED DISEASE; FEMALE; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BRAIN CHEMISTRY; CARBOLINES; CONVULSANTS; DRUG RESISTANCE; EVALUATION STUDIES; FEMALE; MALE; MICE; MICE, MUTANT STRAINS; PENTYLENETETRAZOLE; PREGNANOLONE; PREGNENOLONE; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; SEIZURES;

EID: 0029943050     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Bäckström T, Andersson A, Baird DT, Selstam G (1986) The human corpus luteum secretes 5α-pregnane-3,20-dione. Acta Endocrinol (Copenh) 111:116-121
2. Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein untilizing the principle of protein-dye binding. Ann Biochem 72:248-254
3. Braestrup C, Nielsen M, Olsen C (1980) Urinary and brain β-carboline-3-carboxylate as potent inhibitors of brain benzodiazepine receptors. Proc Natl Acad Sci USA 77:2288-2292
4. Braestrup C, Schmiechen R, Neef G, Nielsen M, Petersen EN (1982) Interaction of convulsive ligands with benzodiazepine receptors. Science 216:1241-1243
5. A/benzodiazepine receptor polypeptides from the surface of chick cortical neurons. J Biol Chem 269:1548-1553
6. Chapouthier G, Bondoux D, Martin B, Desforges C, Launay JM (1991) Genetic difference in sensitivity to β-carboline: evidence for the involvement of brain benzodiazepine receptors. Brain Res 553:342-346
7. Corpéchot C, Young J, Calvel M, Wehrey C, Veltz JN, Touyer G, Mouren M, Prasad VVK, Banner C, Sjövall J, Baulieu EE, Robel P (1993) Neurosteroids: 3α-hydroxy-5α-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats. Endocrinology 133:1003-1009
8. Daabees TT, Mohy El-Din MM, Zeitoun R, Makar A (1981) Injectable and oral contraceptive steroids in relation to some neurotransmitters in the rat brain. Biochem Pharmacol 30:1581-1585
9. Desforges C, Venault P, Dodd RH, Chapouthier G, Roubertoux P (1989) β-Carboline-induced seizures in mice: genetic analysis. Pharmacol Biochem Behav 34:733-737
10. Earley CJ, Leonard BE (1978) GABA and gonadal hormones. Brain Res 155:27-34
11. Grecksch G, Prado de Carvalho L, Venault P, Chapouthier G, Rossier J (1983) Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788. Life Sci 32:2579-2584
12. Green MC (1989) Catalog of mutant genes and polymorphic loci. In: Lyon M, Searle A (eds) Genetic variants and strains of the laboratory mouse. Fischer, Stuttgart, pp 12-404
13. A benzodiazepine receptor: biology and pharmacology. Neurobiol Anx 3:165-188
14. Jo DH, Aït Abdallah M, Young J, Baulieu EE, Robel P (1989) Pregnenolone, dehydroepiandrosterone, and their sulfate and fatty acid esters in the rat brain. Steroids 54:287-297
15. Kosobud AE, Crabbe JC (1990) Genetic correlations among inbred strain sensitivities to convulsions induced by nine convulsant drugs. Brain Res 342:8-16
16. Kosobud AE, Crabbe JC (1993) Sensitivity to N-methyl-D-aspartic acid-induced convulsions is genetically associated with resistance to ethanol withdrawal seizures. Brain Res 610:176-179
17. Kosobud AE, Cross SJ, Crabbe JC (1992) Neural sensitivity to pentylenetetrazol convulsions in inbred and selectively bred mice. Brain Res 592:122-128
18. Lyon MF, Hawkes SG (1970) X-linked gene for testicular feminization in the mouse. Nature 227:1217-1219
19. MacPherson GA (1985) Analysis of radioligand binding experiments: a collection of computer programs for the IBM PC. J Pharmacol Method 14:213-228.
20. A receptor - ligand binding, chloride transport and behaviour. Steroids Neuron Act 153:83-106
21. Majewska MD, Harrisson LN, Schwartz RD, Barker JL, Paul SM. (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232:1004-1007
22. Marley RJ, Wehner JM (1987) Correlation between the enhancement of flunitrazepam binding by GABA and seizure susceptibility in mice. Life Sci 40:2215-2224
23. Marley RJ, Stincomb A, Wehner JM (1988) Further characterization of benzodiazepine receptor differences in long-sleep and short-sleep mice. Life Sci 43:1223-1231
24. Martin B, Desforges C, Chapouthier G (1991) Comparisons between patterns of convulsions induced by two β-carbolines in ten inbred strains of mice. Neurosci Lett 133:73-76
25. Martin B, Marchaland C, Chapouthier G, Motta R (1994) Evidence for a multigenic system controlling β-CCM-induced seizures. Behav Genet 24:285-297
26. Morfin R, Young J, Corpéchot C, Börje I, Sjövall J, Beaulieu EE (1992) Neurosteroids: pregnenolone in human sciatic nerves. Proc Natl Acad Sci USA 89:6790-6793
27. Myslobodsky MS (1993) Proconvulsant and anticonvulsant effects of stress - the role of neuroactive steroids. Neurosci Biobehav Rev 17:129-139
28. Nutt DJ, Lister RG (1988) Strain differences in response to a benzodiazepine receptor inverse agonist (FG 7142) in mice. Psychopharmacology 94:435-436
29. A receptors. FASEB J 4:1469-1480
30. Prado de Carvalho L, Grecksch G, Cavalheiro EA, Dodd RH, Chapouthier G, Rossier J (1984) Characterization of convulsions induced by methyl β-carboline-3-carboxylate in mice. Eur J Pharmacol 103:287-293
31. SAS/STAT (1989) Guide for personal computers: SAS/STAT users guide, version 6. SAS Institute, Cary, NC
32. Seale TW, Abla KA, Roderick TH, Rennert OM, Carney JM (1987) Different genes specify hyporesponsiveness to seizures induced by caffeine and the benzodiazepine inverse agonist, DMCM. Pharmacol Biochem Behav 27:451-456
33. (-) ion channels modulated by multiple drug-binding sites. TIPS 13:446-450
34. Starzl TE, Niemer WT, Dell M, Forgave PR (1953) Cortical and subcortical electric activity in experimental seizures induced by metrazol. J Neuropathol Exp Neurol 12:262-276
35. A/benzodiazepine receptors in chick cortical neurons. J Neurochem 57:1307-1312
36. A/benzodiazepine receptors on clathrin-coated vesicles from rat brain. J Neurochem 60:1755-1761
37. Tenen SS, Hirsch JD (1980) β-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity. Nature 288:609-610
38. Turski L, Niemann W, Stephens DN (1990) Differential effects of antiepileptic drugs and β-carbolines on seizures induced by excitatory amino acids. Neuroscience 39:799-807
39. Wieland S, Lan NC, Mirasedeghi S, Gee KW (1991) Anxiolytic activity of the progesterone metabolite 5-alpha-pregnan-3-alpha-ol-20-one. Brain Res 565:263-268
40. Woodward RM, Polenzani L, Miledi R (1991) Effects of steroids on γ-aminobutyric acid receptors expressed in Xenopus oo-cytes by Poly(A)+ RNA from mammalian brain and retina. Mol Pharmacol 41:89-103