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Volumn 35, Issue 4, 1996, Pages 441-448

EEG seizure activity and behavioral neurotoxicity produced by (+)-MK801, but not the glycine site antagonist L-687,414, in the rat

Author keywords

(+) HA966; (+) MK801; behavioral neurotoxicity; EEG seizures; glycine; L 687,414; N methyl D aspartate (NMDA)

Indexed keywords

3 AMINO 1 HYDROXY 2 PYRROLIDINONE; 3 AMINO 1 HYDROXY 4 METHYL 2 PYRROLIDINONE; ANTICONVULSIVE AGENT; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

EID: 0029942928     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(95)00190-5     Document Type: Article
Times cited : (18)

References (24)
  • 1
    • 0015154486 scopus 로고
    • 1-Hydroxy-3-amino-pyrrolidone-2 (HA966): A new GABA-like compound, with potential use in extrapyramidal diseases
    • Bonta I. L., De Vos C. J., Grijsen H., Hillen F. C., Noach E. L. and Sim A. W. (1971) 1-Hydroxy-3-amino-pyrrolidone-2 (HA966): a new GABA-like compound, with potential use in extrapyramidal diseases. Br. J. Pharmacol. 43: 514-535.
    • (1971) Br. J. Pharmacol. , vol.43 , pp. 514-535
    • Bonta, I.L.1    De Vos, C.J.2    Grijsen, H.3    Hillen, F.C.4    Noach, E.L.5    Sim, A.W.6
  • 2
    • 0025396451 scopus 로고
    • Do NMDA antagonists protect against cerebral ischemia: Are clinical trials warranted?
    • Buchan A. M. (1990) Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted? Cereb. Brain Metab. Rev. 2: 1-26.
    • (1990) Cereb. Brain Metab. Rev. , vol.2 , pp. 1-26
    • Buchan, A.M.1
  • 3
    • 0027309113 scopus 로고
    • NMDA receptors and AMPA/kainate receptors mediate parallel injury in cerebral cortical cultures subjected to oxygen-glucose deprivation
    • Choi D. W. (1993) NMDA receptors and AMPA/kainate receptors mediate parallel injury in cerebral cortical cultures subjected to oxygen-glucose deprivation. Prog. Brain Res. 96: 137-143.
    • (1993) Prog. Brain Res. , vol.96 , pp. 137-143
    • Choi, D.W.1
  • 4
    • 0025228762 scopus 로고
    • D-Serine antagonized phencyclidine- and MK-801-induced stereotyped behavior and ataxia
    • Contreras P. C. (1990) D-Serine antagonized phencyclidine- and MK-801-induced stereotyped behavior and ataxia. Neuropharmacology 29: 291-293.
    • (1990) Neuropharmacology , vol.29 , pp. 291-293
    • Contreras, P.C.1
  • 5
    • 0342919895 scopus 로고
    • PD117302, an opioid kappa agonist, and MK801 partially block maximal electroshock convulsion-induced increases in c-fos mRNA in rat brain
    • Dave J. R. and Tortella F. C. (1992) PD117302, an opioid kappa agonist, and MK801 partially block maximal electroshock convulsion-induced increases in c-fos mRNA in rat brain. Pharmacol. Comm. 1: 319-328.
    • (1992) Pharmacol. Comm. , vol.1 , pp. 319-328
    • Dave, J.R.1    Tortella, F.C.2
  • 7
    • 0028852625 scopus 로고
    • The neuroprotective effect of the glycine site antagonist 3R-(+)-cis-4-methyl-HA966 (L-687,414) in a rat model of focal ischemia
    • Gill R., Hargreaves R. J. and Kemp J. A. (1995) The neuroprotective effect of the glycine site antagonist 3R-(+)-cis-4-methyl-HA966 (L-687,414) in a rat model of focal ischemia. J. Cereb. Blood Flow Metab. 15: 197-204.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 197-204
    • Gill, R.1    Hargreaves, R.J.2    Kemp, J.A.3
  • 8
    • 0027294037 scopus 로고
    • Lack of effect of L-687,414 [(+)-cis-4-methyl-HA-966], an NMDA receptor antagonist acting at the glycine site, on cerebral glucose metabolism and cortical neuronal morphology
    • Hargreaves R. J., Rigby M., Smith D. and Hill R. G. (1993) Lack of effect of L-687,414 [(+)-cis-4-methyl-HA-966], an NMDA receptor antagonist acting at the glycine site, on cerebral glucose metabolism and cortical neuronal morphology. Br. J. Pharmacol. 110: 36-42.
    • (1993) Br. J. Pharmacol. , vol.110 , pp. 36-42
    • Hargreaves, R.J.1    Rigby, M.2    Smith, D.3    Hill, R.G.4
  • 10
    • 0027469106 scopus 로고
    • The glycine site of the NMDA receptor - Five years on
    • Kemp J. A. and Leeson P. D. (1993) The glycine site of the NMDA receptor - five years on. Trends Pharmacol. Sci. 14: 20-25.
    • (1993) Trends Pharmacol. Sci. , vol.14 , pp. 20-25
    • Kemp, J.A.1    Leeson, P.D.2
  • 11
    • 0342485745 scopus 로고
    • The implication and significance of EEG and sleep-awake activity in the study of experimental drug dependence on morphine
    • Ehrenpreis S. and Neidle A., eds, Marcel Dekker, New York
    • Khazan N. (1975) The implication and significance of EEG and sleep-awake activity in the study of experimental drug dependence on morphine. In: Methods in Narcotic Research (Ehrenpreis S. and Neidle A., eds), pp. 173-215. Marcel Dekker, New York.
    • (1975) Methods in Narcotic Research , pp. 173-215
    • Khazan, N.1
  • 12
    • 0024331399 scopus 로고
    • Effects of MK-801 upon local cerebral glucose utilization in conscious rats and in rats anesthetized with halothane
    • Kurumaji A. and McCulloch J. (1989) Effects of MK-801 upon local cerebral glucose utilization in conscious rats and in rats anesthetized with halothane. J. Cereb. Blood Flow Metab. 9: 786-794.
    • (1989) J. Cereb. Blood Flow Metab. , vol.9 , pp. 786-794
    • Kurumaji, A.1    McCulloch, J.2
  • 13
    • 0025251601 scopus 로고
    • Effects of five-membered ring conformation on bioreceptor recognition: Identification of 3R-amino-1-hydroxy-4R-methylpyrrolidin-2-one (L-687,414) as a potent glycine/N-methyl-D-aspartate receptor antagonist
    • Leeson P. D., Williams B. J., Baker R., Ladduwahety T., Moore K. W. and Rowley M. (1990) Effects of five-membered ring conformation on bioreceptor recognition: Identification of 3R-amino-1-hydroxy-4R-methylpyrrolidin-2-one (L-687,414) as a potent glycine/N-methyl-D-aspartate receptor antagonist. J. Chem. Soc. Chem. Commun.: 1578-1580.
    • (1990) J. Chem. Soc. Chem. Commun. , pp. 1578-1580
    • Leeson, P.D.1    Williams, B.J.2    Baker, R.3    Ladduwahety, T.4    Moore, K.W.5    Rowley, M.6
  • 14
    • 0027988561 scopus 로고
    • The glycine site on the NMDA receptor: Structure-activity relationships and therapeutic potential
    • Leeson P. D. and Iversen L. L. (1994) The glycine site on the NMDA receptor: Structure-activity relationships and therapeutic potential. J. med. Chem. 37: 4053-4067.
    • (1994) J. Med. Chem. , vol.37 , pp. 4053-4067
    • Leeson, P.D.1    Iversen, L.L.2
  • 15
    • 0026076110 scopus 로고
    • Autoradiographic assessment of the effects of N-methyl-D-aspartate (NMDA) receptor antagonists in vivo
    • McCulloch J. and Iversen L. L. (1991) Autoradiographic assessment of the effects of N-methyl-D-aspartate (NMDA) receptor antagonists in vivo. Neurochem. Res. 16: 951-963.
    • (1991) Neurochem. Res. , vol.16 , pp. 951-963
    • McCulloch, J.1    Iversen, L.L.2
  • 16
    • 0025373705 scopus 로고
    • The effects of N-methyl-D-aspartate receptor blockade with MK-801 upon the relationship between cerebral blood flow and glucose utilization
    • Nehls D. G., Park C. K., MacCormack A. G. and McCulloch J. (1990) The effects of N-methyl-D-aspartate receptor blockade with MK-801 upon the relationship between cerebral blood flow and glucose utilization. Brain Res. 511: 271-279.
    • (1990) Brain Res. , vol.511 , pp. 271-279
    • Nehls, D.G.1    Park, C.K.2    MacCormack, A.G.3    McCulloch, J.4
  • 17
    • 0024338054 scopus 로고
    • Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs
    • Olney J. W., Labruyere J. and Price M. T. (1989) Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244: 1515-1518.
    • (1989) Science , vol.244 , pp. 1515-1518
    • Olney, J.W.1    Labruyere, J.2    Price, M.T.3
  • 18
    • 0027176541 scopus 로고
    • Therapeutic potential of excitatory amino acid antagonists: Channel blockers and 2,3-benzodiazepines
    • Rogawski M. A. (1993) Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines. Trends Pharmacol. Sci. 14: 325-331.
    • (1993) Trends Pharmacol. Sci. , vol.14 , pp. 325-331
    • Rogawski, M.A.1
  • 21
    • 0026586062 scopus 로고
    • The glycine site NMDA receptor antagonist, A-(+)-cis-β-methyl-3-amino-1-hydroxy-pyrrolid-2-one, L-687,414 is anticonvulsant in baboons
    • Smith S. E. and Meldrum B. S. (1992) The glycine site NMDA receptor antagonist, A-(+)-cis-β-methyl-3-amino-1-hydroxy-pyrrolid-2-one, L-687,414 is anticonvulsant in baboons. Eur. J. Pharmacol. 211: 109-111.
    • (1992) Eur. J. Pharmacol. , vol.211 , pp. 109-111
    • Smith, S.E.1    Meldrum, B.S.2
  • 23
    • 0022651935 scopus 로고
    • U50,488, a highly selective kappa opioid: Anticonvulsant profile in rats
    • Tortella F. C., Robles L. and Holaday J. W. (1986) U50,488, a highly selective kappa opioid: Anticonvulsant profile in rats. J. Pharmacol. Exp. Ther. 237: 49-53.
    • (1986) J. Pharmacol. Exp. Ther. , vol.237 , pp. 49-53
    • Tortella, F.C.1    Robles, L.2    Holaday, J.W.3
  • 24
    • 0343355131 scopus 로고
    • Electroencephalographic seizure activity produced by MK801 but not by the gly-site NMDA antagonist L-687,414
    • Tortella F. C. and Hill R. G. (1993) Electroencephalographic seizure activity produced by MK801 but not by the gly-site NMDA antagonist L-687,414. Neurosci. Abst. 19: 1697.
    • (1993) Neurosci. Abst. , vol.19 , pp. 1697
    • Tortella, F.C.1    Hill, R.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.