Azelastine: Well known ciliotoxic agent?

International Journal of Pharmaceutics

Volumn 136, Issue 1-2, 1996, Pages 181-183

  Garay, R P ^a  

^a FACULTÉ DE MÉDECINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AZELASTINE; BENZALKONIUM CHLORIDE; CETIRIZINE;

ALLERGIC RHINITIS; CILIARY MOTILITY; DRUG EFFECT; GUINEA PIG; HUMAN; INTRANASAL DRUG ADMINISTRATION; LETTER; MUCOCILIARY TRANSPORT; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029942835     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(96)04472-9     Document Type: Letter

References (16)

1. Achterrath-Tuckermann, U., Saano, V., Minker, E., Stroman, F., Arny, I., Joki, S., Nuutinen, J. and Szelenyi, I. Influence of azelastine and some selected drugs on mucociliary clearance. Lung, 170 (1992) 201-209 .
2. Ainge, G., Bowles, J.A.K., McCormick, S.G., Richards, D.H. and Scales, M.D.C. Lack of deleterious effects of corticosteroid sprays containing benzalkonium chloride on nasal ciliated epithelium. In vivo results in laboratory animals. Drug. Invest., 8 (1994) 127-133.
3. Batts, A.H., Marriot, C., Martin, G.P., Wood, C.F. and Bond, S.W. The effects of some preservatives used in nasal preparations on the mucus and ciliary components of mucociliary clearance. J. Pharm. Pharmacol., 42 (1990) 145-151.
4. Braat, J.P.M., Ainge, G., Bowles, J.A.K., Richards, D.H., Van Riessen, D., Visser, W.J. and Rinjtes, E. The lack of effect of benzalkonium chloride on the cilia of the nasal mucosa in patients with perennial allergic rhinitis: a combined functional, light, scanning and transmission electron microscopy study. Clin. Expl. Allergy, 25 (1995) 957-965.
5. Bos, V.J.H. and Jongkees, L.B.W. Nasentrpfen und flimmerhärchenbewegung in menschlichem gewebe. Allergie und Asthma, 12 (1966) 36-37.
6. Fukuda, T., Saito, M., Yoshidomi, M. and Ito, K. Influence of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl) benzimidazole difumarate (KB-2413), a new antiallergic, on ciliary movement. Arzneimittelforsch., 34 (1984) 816-818.
7. Hermens, W.A.J.J. and Merkus, F.W.H.M. The influence of drugs on nasal ciliary movement. Pharm. Res., 4 (1987) 445-449.
8. Karttunen, P., Silvasti, M., Virta, P., Saano, V. and Nuutinen, J. The effect of vadocaine, dextromethorphan, diphenhydramine and hydroxyzine on the ciliary beat frequency in rats in vitro. Pharmacol. Toxicol., 67 (1990) 159-161.
9. Klimek, L. and Mosges, R. Therapeutic management of mucociliary transport disturbances in allergic rhinitis. Eur. Resp. J., 8 (Suppl. 19) (1995) P 1298 .
10. Merkus, F.W.H.M. and Schüsler-van Hees, M.T.I.W. Influence of levocabastine suspension on ciliary beat frequency and mucociliary clearance. Allergy, 47 (1992) 230-233.
11. Pasali, D. and Piragine, F. A comparison of azelastine nasal spray and cetirizine tablets in the treatment of allergic rhinitis. J. Int. Med. Res., 22 (1994) 17-23.
12. Su, X.Y. and Li Wan Po, A. The effect of some comercially available antihistamine and decongestant intra-nasal formulations on ciliary beat frequency. J. Clin. Pharm. Ther., 18 (1993) 219-222.
13. Su, X.Y., Mattern, C., Häcker, R. and Li Wan Po, A. Does sea water made isotonic affect ciliary beat frequency? Int. J. Pharm. 123 (1995) 47-51.
14. Tamaoki, J., Chiyotani, A., Sakai, N., Takeyama, K. and Konno, K. Effect of azelastine on sulphur doixide induced impairment of ciliary motility in airway epithelium. Thorax, 48 (1993) 542 546.
15. Van de Donk, H.J.M., Van den Heuvel, A.G.M., Zuidema, J. and Merkus, F.W.H.M. The effects of nasal drops and their additives on human nasal mucociliary clearance. Rhinology, 20 (1982) 127-137.
16. Van de Donk, H.J.M., Zuidema, J. and Merkus, F.W.H.M. The effects of nasal drops on the ciliary beat frequency of chicken embryo tracheas. Rhinology, 19 (1981) 215-230.