Quantitation of a new potent angiotensin II receptor antagonist, TCV-116, and its metabolites in human serum and urine

Journal of Chromatography B: Biomedical Applications

Volumn 677, Issue 1, 1996, Pages 123-132

  Miyabayashi, Tetsushiro ^a   Okuda, Teruaki ^a   Motohashi, Michio ^a   Izawa, Kenji ^a   Yashiki, Takatsuka ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Angiotensin II receptor antagonist; TCV 116

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; CANDESARTAN HEXETIL; DRUG METABOLITE;

ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; DRUG URINE LEVEL; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; QUANTITATIVE ASSAY; TECHNIQUE; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0029942683     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4347(95)00405-X     Document Type: Article

References (14)

1. K. Kubo, Y. Inada, Y. Kohara, Y. Sugiura, M. Ojima, K. Itoh, Y. Furukawa, K. Nishikawa and T. Naka, J. Med. Chem., 36 (1993) 1772.
2. K. Kubo, Y. Kohara, E. Imamiya, Y. Sugiura, Y. Inada, Y. Furukawa, K. Nishikawa and T. Naka, J. Med. Chem., 36 (1993) 2182.
3. Y. Shibouta, Y. Inada, M. Ojima, T. Wada, M. Noda, T. Sanada, K. Kubo, Y. Kohara, T. Naka and K. Nishikawa, J. Pharm. Exp. Ther., 266 (1993) 114.
4. M. Noda, Y. Showboat, Y. Inada, M. Ojima, T. Wada, T. Sanada, K. Kubo, Y. Kohara, T. Naka and K. Nishikawa, Biochem. Pharmacol., 46 (1993) 311.
5. K. Mizuno, S. Niimura, M. Tani, I. Saito, H. Sanada, M. Takahashi, K. Okazaki, M. Yamaguchi and S. Fukuchi, Life Sci. 51 (1992) 183.
6. S. Tanayama, unpublished data.
7. T. Ogihara, H. Mikami, J. Higaki, M. Nagano, K. Higashimori, K. Kohara, J. Azuma, T. Aoki, Y. Hamanaka, J. Clin. Therap. Med., 9 (1993) 1031.
8. K. Yamashita, M. Motohashi and T. Yashiki, J. Chromatogr., 487 (1989) 357.
9. T. Miyabayashi, K. Yamashita, I. Aoki, M. Motohashi, T. Yashiki and K. Yatani, I. Chromatogr., 494 (1989) 209.
10. M. Yamaguchi, K. Yamashita, I. Aoki, T. Tabata, S. Hirai and T. Yashiki, J. Chromatogr., 575 (1992) 123.
11. T. Miyabayashi and M. Motohashi, unpublished data.
12. S.R. Rabel, J.F. Stobaugh, R. Heinig and J.M. Bostick, J. Chromatogr., 617 (1993) 79.
13. N. So, D.P. Chandra, I.S. Alexander, V.J. Webster, D.W.O. Hughes, I. Chromatogr., 337 (1985) 81.
14. M. Ohtawa, F. Takayama, K. Saitoh, T. Yashinaga and M. Nakashima, Br. J. Clin. Pharmac. 35 (1993) 290.