A non-peptidic photoactivatable antagonist for mapping the antagonist binding site of the tachykinin NK2 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 6, 1996, Pages 605-608

  Kersey, Ian D ^a   Bhogal, Nirmala ^a   Donnelly, Dan ^a   Fishwick, Colin W G ^a   Findlay, John B C ^a   Ward, Peter ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZIRIDINE DERIVATIVE; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR ANTAGONIST; SAREDUTANT;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; NONHUMAN; PHOTOACTIVATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 0029942633     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00075-3     Document Type: Article

References (25)

1. Maggi, C. A.; Patacchinni, R.; Rovero, P.; Giachetti, A. J.Auton.Pharmacol. 1993, 13, 23-93.
2. Rees, D. C.; Annu.Rep.Med.Chem. 1994, 28, 59-68.
3. a) Bayley, H. "Photogenerated Reagents in Biochemistry and Molecular Biology," Elsevier, Amsterdam, New York, 1983:
4. b) Schuster, D. I.; Probst, W. C.; Ehrlich, G. K.; Singh, G. Photochem.Photobiol. 1989, 49, 785-804.
5. a) Emonds-Alt, X.; Vilain, P.; Goulaouic, P.; Proietto, V.; Van Broeck, D.; Advenier, C.; Naline, E.; Neliat, G.; Le Fur, G.; Brelière, J-C. Life Sci 1992, 50, 101-106:
6. b) Emonds-Alt, X.; Advenier, C.; Croci, T.; Manara, L.; Neliat, G.; Poncelet, M.; Proietto, V.; Santucci, V.; Soubrie, P.; Van Broeck, D.; Vilain, P.; Le Fur, G.; Brelière, J-C. Regul.Pept. 1993, 46, 31-36:
7. c) Emonds-Alt, X.; Golliot, F.; Pointeau, P.; Le Fur, G.; Brelière, J-C. Biochem.Biophys.Res.Commun. 1993, 191, 1172-1177:
8. d) Emonds-Alt, X.; Proietto, V.; Van Broeck, D.; Vilain, P.; Advenier, C.; Neliat, G.; Le Fur, G.; Brelière, J-C. BioMed.Chem.Lett. 1993, 3, 925-930.
9. Cooper, A. W. J.; Adams, H. S.; Bell, R.; Gore, P. M.; McElroy, A. B.; Pritchard, J. M.; Smith, P. W.; Ward, P. BioMed. Chem.Lett. 1994, 4, 1951-1956.
10. a) Brunner, J.; Senn, H.; Richards, F. M. J.Biol.Chem. 1980, 255, 3313-3318:
11. b) Nassal, M. J.Am.Chem.Soc. 1984, 106, 7540-7545:
12. c) Platz, M.; Admasu, A. S.; Kwiatkowski, S ; Crodker, P. J.; Imai, N.; Watt, D. S. Bioconjugate Chem. 1991, 2, 337-341.
13. Hale, J. J.; Finke, P. E.; MacCoss, M. BioMed.Chem.Lett. 1993, 3, 319-322.
14. Yoshida, E.; Nakayama, H.; Hatanaka, Y.; Kanaoka, Y. Chem.Pharm.Bull. 1990, 38, 982-987.
15. Aizpurua, J. M.; Palomo, C. Tetrahedron Lett. 1985, 26, 475-476.
16. Findlay, J. B. C.; Fishwick, C. W. G.; Kersey, I. D.; Ward, P. Synthesis, 1995, 5, 553-556.
17. Corey, E. J.; Venkateswarlu, A. J.Am.Chem.Soc. 1972, 94, 6190-6191.
18. Nassal, M. Liebigs Ann.Chem. 1983, 1510-1523.
19. Mancuso, A. J.; Huang, S-L.; Swern, D. J.Org.Chem. 1978, 43, 2480-2482.
20. Corey, E. J.; Suggs, J. W. Tetrahedron Lett. 1975, 2647-2650.
21. Borch, R. F.; Bernstein, M. D.; Durst, H. D. J.Am.Chem.Soc. 1971, 93, 2897-2903.
22. Leonard, N. H.; Paukstelis, J. V. J.Org.Chem. 1963, 28, 3021-3024.
23. All new compounds gave satisfactory analytical and spectroscopic data.
24. Gether, U.; Yokota, Y.; Emonds-Alt, X.; Brelière, J-C.; Lowe, J. A. III; Snider, R. M.; Nakanishi, S.; Schwartz, T. W. Proc. Natl.Acad.Sci.USA. 1993, 90, 6194-6198.
25. Bhogal, N.; Donnelly, D.; Findlay, J. B. C. J.Biol.Chem. 1994, 269, 27269-27274.