Allopurinol, an inhibitor of xanthine oxidase, reduces uric acid levels and modifies the signs associated with copper deficiency in rats fed fructose

Free Radical Biology and Medicine

Volumn 20, Issue 4, 1996, Pages 595-600

  Fields, Meira ^a   Lewis, Charles G ^a   Lure, Mark D ^a  

^a BELTSVILLE HUMAN NUTRITION RESEARCH CENTER   (United States)

Author keywords

Allopurinol; Free radicals; Uric acid; Xanthine oxidase

Indexed keywords

ALLOPURINOL; FRUCTOSE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CARBOHYDRATE METABOLISM; COMPETITIVE INHIBITION; CONTROLLED STUDY; COPPER DEFICIENCY; DRUG EXCRETION; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH RATE; HYPERURICEMIA; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REVIEW; URIC ACID BLOOD LEVEL;

ANIMALIA;

EID: 0029942540     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(95)02056-X     Document Type: Article

References (42)

1. Fields, M.; Ferretti, R. J.; Smith, J. C.; Reiser, S. The severity of copper deficiency is determined by the type of dietary carbohydrate. Proc. Soc. Exp. Biol. Med. 175:530-537; 1984.
2. Fields, M.; Ferretti, R. J.; Smith, J. C. Interaction between dietary carbohydrate and copper nutriture on lipid peroxidation in rat tissues. Biol. Trace Elem. Res. 6:379-391; 1984.
3. Redman, R. S.; Fields, M.; Reiser, S.; Smith, J. C. Dietary fructose exacerbates the cardiac abnormalities of copper deficiency in rats. Atherosclerosis 74:203-214; 1988.
4. Fields, M.; Lewis, C. G.; Lure, M. D. The influence of dietary carbohydrate and deferoxamine on developing copper deficiency in rats. Metabolism 41:659-665; 1992.
5. Van Den Berghe, G. Metabolic effects of fructose in the liver. Curr. Top. Cell. Regul. 13:97-135; 1978.
6. Van Den Berghe, G. Fructose: Metabolism and short-term effects on carbohydrate and purine metabolic pathways. Prog. Biochem. Pharmacol. 21:1-32; 1986.
7. Perheentupa, J.; Raivio, K. Fructose-induced hyperuricaemia. Lancet ii:528-531; 1967.
8. Philips, M. I.; Davies, D. R. The mechanism of guanosine triphosphate depletion in the liver after a fructose load. The role of fructokinase. Biochem. J. 228:667-671; 1985.
9. Raivio, K. O.; Kekomaki, M. P.; Maenpaa, P. H. Depletion of liver adenine nucleotides induced by D-fructose. Dose dependence and specificity of the fructose effect. Biochem. Pharmacol. 18:2615-2624; 1969.
10. Watts, R. W. E.; Watts, J. E. M.; Seegmiller, J. E. Xanthine oxidase activity in human tissues and its inhibition by allopurinol (4-hydroxypyrazol [3,4-d] pyrimidine). J. Lab. Clin. Med. 66:688-697; 1965.
11. 2-dependent (Type 0) forms of rat liver xanthine dehydrogenase. Arch. Biochem. Biophys. 172:354-364; 1976.
12. Paynter, D. I.; Moir, R. J.; Underwood, E. J. Changes in activity of the Cu-Zn superoxide dismutase enzyme in tissues of the rat with changes in dietary copper. J. Nutr. 109:1570-1576; 1979.
13. Elion, G. B. Enzymatic and metabolic studies with allopurinol. Ann. Rheum. Dis. 25:608-614; 1966.
14. Elion, G. B.; Kovensky, A.; Hitchings, G. H.; Metz, E.; Rundles, R. W. Metabolic studies of allopurinol an inhibitor of xanthine oxidase. Biochem. Pharmacol. 15:863-880; 1966.
15. Hitchings, G. H. Pharmacology of allopurinol. Arthritis Rheum. 18:863-870; 1975.
16. Pomales, R.; Bieber, S.; Friedman, R. Augmentation of the incorporation of hypoxanthine into nucleic acids by the administration of an inhibitor of xanthine oxidase. Biochem. Biophys. Acta 72:119-120; 1963.
17. Begsland, J.; LoBalsamo, L.; Lajos, P.; Mookerjee, B. Postanoxic hemodynamic performance. The effect of allopurinol and superoxide dismutase/catalase. Transplant. Proc. 19:4165-4166; 1987.
18. Im, M. J.; Manson, P. N.; Bulkley, G. B.; Hoopes, J. E. Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps. Ann. Surg. 201:357-359; 1985.
19. Garcia, J. G.; Rollan, C. M.; Enrinquez, M. A. E.; Madguda, M. H.; Hermandez, E. M.; Nunez, J. F. M.; Alonso, A. G. Improved survival in intestinal ischemia by allopurinol not related to xanthine oxidase inhibitor. J. Surg. Res. 48:144-146; 1990.
20. Johnson, W. D.; Kayser, K. L.; Brenowitz, J. B. A randomized and controlled trial of allopurinol in coronary bypass surgery. Am. Heart J. 121:20-24; 1991.
21. Rashid, M. A.; Williams-Olsson, G. Influence of allopurinol on cardiac complications in open heart operations. Ann. Thorac. Surg. 52:127-130; 1991.
22. Tabayashi, K.; Suzuki, Y.; Nagamine, S. A clinical trial of allopurinol (Zyloric) for myocardial protection. J. Thorac. Cardiovas. Surg. 101:713-718; 1991.
23. Hill, A. D.; Patterson, K. Y.; Veillon, C.; Morris, E. R. Digestion of biological materials for mineral analysis using a combination of wet and dry ashing. Anal. Chem. 58:2340-2342; 1986.
24. Roussos, G. G. Xanthine oxidase from bovine small intestine. Methods Enzymol. 12A:5-16; 1967.
25. Lowry, O. H.; Rosenbrough, N. J.; Farr, A. L.; Randall, A. J. Protein Measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275; 1951.
26. Paynter, D. I. The role of dietary copper, manganese, selenium and vitamin E in lipid peroxidation in tissues of the rat. Biol. Trace Elem. Res. 2:121-135; 1980.
27. Hunter, F. E.; Gebicke, J. M.; Hoffstein, P. E.; Weinstein, J.; Scott, A. Swelling and lysis of rat liver mitochondria induced by ferrous ions. J. Biol. Chem. 238:828-835; 1963.
28. Howell, S. B.; Wung, W. E.; Taetle, R.; Hussain, F.; Romine, J. S. Modulation of 5-fluorouracil toxicity by allopurinol in man. Cancer 48:1281-1289; 1981.
29. Burton, K. P.; McCord, J. M.; Ghai, G. Myocardial alterations due to free radical generation. Am. J. Physiol. 246:H776-H783; 1984.
30. Gupta, M.; Gameiro, A.; Singal, P. K. Reduced vulnerability of the hypertrophied rat heart to oxygen radical injury. Can. J. Physiol. Pharmacol. 65:1157-1164; 1987.
31. Blaustein, A. S.; Schine, L.; Brooks, W. W.; Fanburg, B. L.; Bing, O. H. L. Influence of exogenously generated oxidant species on myocardial function. Am. J. Physiol. 250:H595-H599; 1986.
32. Gupta, M.; Singal, P. K. Higher antioxidant capacity during a chronic stable heart hypertrophy. Circulation Res. 64:398-406; 1989.
33. Gupta, M.; Singal, P. K. Oxygen radical injury in the presence of desferal, a specific iron chelating agent. Biochem. Pharmacol. 36:3774-3777; 1987.
34. Pomales, R.; Elion, G. B.; Hitchings, G. H. Xanthine as precursor of nucleic acid purines in the mouse. Biochem. Biophys. Acta 95-96:505-506; 1965.
35. Kramer, T. R.; Johnson, W. T.; Briske-Anderson, M. Influence of iron and the sex of the rats on hematological, biochemical and immunological changes during copper deficiency. J. Nutr. 118:214-221; 1988.
36. Fields, M.; Lewis, C. G.; Scholfield, D. Female rats are protected against the fructose induced mortality of copper deficiency. Proc. Soc. Exp. Biol. Med. 183:145-149; 1986.
37. Fields, M.; Lewis, C. G.; Lure, M. D. Hypothesis: The requirements for copper are determined by growth rate in rats fed fructose but not in rats fed starch. J. Appl. Nutr. 45:85-96; 1993.
38. Williams, D. M.; Kennedy, F. S.; Green, B. G. Hepatic iron accumulation in copper-deficient rats. Br. J. Nutr. 50:653-660; 1983.
39. Green, R.; Levin, M. B.; Samassa, D.; Charlton, R. W.; Bothwell, T. H. The effect of allopurinol on iron metabolism. SA Med. J. 3:776-779; 1988.
40. Boyett, J. D.; Vogler, W. R.; De Paula Furtado, B.; Schmidt, F. H. Allopurinol and iron metabolism in man. Blood 32:460-468; 1968.
41. Emmerson, B. T. Effects of allopurinol on iron metabolism in man. Ann. Rheum. Dis. 25:700-703; 1966.
42. Green, S.; Mazur, A. Relation of uric acid metabolism to release of iron from hepatic ferritin. J. Biol. Chem. 227:653-656; 1957.