Lymphoid infiltrates of the salivary glands: Pathology, biology, and clinical significance

Current Opinion in Oncology

Volumn 8, Issue 3, 1996, Pages 232-237

  DiGiuseppe, Joseph A ^a   Corio, Russell L ^a   Westra, William H ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL LYMPHOMA; HISTOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTIC INFILTRATION; PRIORITY JOURNAL; REVIEW; SALIVARY GLAND TUMOR;

EID: 0029941801     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001622-199605000-00011     Document Type: Review

References (36)

1. Schmid U, Helbron D, Lennert K: Development of malignant lymphoma in myoepithelial sialadenitis (Sjögren's syndrome). Virchows Arch A Pathol Anat Histopathol 1982, 395:11-43.
2. Daniels TE: Benign Lymphoepithelial Lesions and Sjögren's Syndrome. In Surgical Pathology of the Salivary Glands. Edited by Ellis GL, Auclair PL, Gnepp DR. Philadelphia: WB Saunders; 1991:83-106.
3. Peel RL, Gnepp DR: Diseases of the Salivary Glands. In Surgical Pathology of the Head and Neck. Edited by Barnes L. New York: Marcel Dekker; 1985:537-541.
4. Azzopardi JG, Evans DJ: Malignant lymphoma of parotid associated with Mikulicz disease (benign lymphoepithelial lesion). J Clin Pathol 1971, 24:744-752.
5. Pinkus GS, Dekker A: Benign lymphoepithelial lesion of the parotid glands associated with reticulum cell sarcoma. Cancer 1970, 25:121-127.
6. Stewart A: Bilateral parotid MALT lymphoma and Sjögren's syndrome. Br J Oral & Maxillotac Surg 1994, 32:318-322.
7. Kassan SS, Thomas TL, Moutsopoulos HM, Hoover R, Kimberly RP, Budman DR, Costa J, Decker JL, Chused TM: Increased risk of lymphoma in Sicca syndrome. Ann Intern Med 1978, 89:888-892.
8. Fishelder A, Tubbs R, Hesse B, Levine H: Uniform detection of immunoglobulin-gene rearrangement in benign lymphoepithelial lesions. N Engl J Med 1987, 316:1118-1121.
9. Isaacson P, Wright DH: Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer 1984, 53:2515-2524.
10. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, de Wolf-Peeters C, Falini B, Gatter KC, et al.: A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994, 84:1361-1392.
11. Isaacson PG, Spencer J: Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology 1987, 11:445-462.
12. Isaacson PG, Spencer J: The biology of low grade MALT lymphoma. J Clin Pathol 1995, 48:395-397. An outstanding review concisely summarizing current understanding of the pathogenesis of low-grade B-cell lymphoma of MALT.
13. Isaacson PG, Wotherspoon AC, Pan L: Follicular colonization in B-cell lymphoma of mucosa-associated lymphoid tissue. Am J Surg Pathol 1991, 15:819-828.
14. Wotherspoon AC, Pan L, Diss TC, Isaacson PG: Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue. Cancer Genet Cytogenet 1992, 58:35-38.
15. Horsman D, Gascoyne R, Klasa R, Coupland R: t(11;18)(q21;121.1): a recurring translocation in lymphomas of mucosa-associated lymphoid tissue (MALT)? Genes Chromosom Cancer 1992, 4:183-187.
16. Diss TC, Wotherspoon AC, Speight P, Pan L, Isaacson PG: B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. Am J Surg Pathol 1995, 19:531-536. The authors demonstrate a high prevalence of monoclonality and describe the histologic correlates of monoclonality in a large series of salivary gland lymphoid lesions. In addition, a clonal relationship is established between parotid lesions and ertraparotid progression in a subset of these patients.
17. Pisa EK, Pisa P, Kang H, Fox RI: High frequency of t(14;18) translocation in salivary gland lymphomas from Sjögren's syndrome patients. J Exp Med 1991, 174:1245-1250.
18. Wotherspoon AC, Finn TM, Isaacson PG: Trisomy 3 in low-grade B-cell lymphomas of mucosa-associated lymphoid tissue. Blood 1995, 85:2000-2004. Demonstration of trisomy 3 as a common cytogenetic abnormality in MALT-type lymphomas. Eighty-two percent of 11 salivary gland MALT lymphomas studied manifested trisomy 3.
19. Hyjek E, Smith WJ, Isaacson PG: Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol 1988, 19:766-776.
20. Falzon M, Isaacson PG: The natural history of benign lymphoepithelial lesion of the salivary gland in which there is a monoclonal population of B cells. Am J Surg Pathol 1991, 15:59-65.
21. Hsi ED, Zukerberg LR, Schnitzer B, Harris NL: Development of extrasalivary gland lymphoma in myoepithelial sialadenitis. Mod Pathol 1995, 8:817-824. This study describes a correlation between monotypic plasma cell immunoglobulin and broad strands of monocytoid B cells in salivary gland lesions with the development of extra-salivary lymphomas.
22. Bodeutsch C, deWilde PCM, Kater L, van den Hoogen FHJ, Henre RJ, van Houwelingen JC, van de Putte LBA, Vooijs GP: Monotypic plasma cells in labial salivary glands of patients with Sjögren's syndrome: prognosticator for systemic lymphoproliferative disease. J Clin Pathol 1993, 46:123-128.
23. Jordan RCK, Pringle JH, Speight PM: High frequency of light chain restriction in labial gland biopsies of Sjögren's syndrome detected by in situ hybridization. J Pathol 1995, 177:35-40. Molecular detection of monotypic immunoglobulin in B cells and plasma cells in labial salivary gland biopsies from Sjögren's syndrome patients is associated with an increased risk of extra-salivary lymphoma.
24. Schiodt M: HIV-associated salivary gland disease: a review. Oral Surg Oral Med Oral Pathol 1992, 73:164-167.
25. Seifert G: Tumour-like lesions of the salivary glands. Pathol Res Pract 1992, 188:836-846.
26. Ryan JR, Ioachim HL, Marmer J, Loubeau JM: Acquired immune deficiency syndrome: related lymphadenopathies presenting in the salivary gland lymph nodes. Arch Otolaryngol Head Neck Surg 1985, 111:554-556.
27. Ioachim HL, Ryan JR, Loaugrund SM: Salivary gland lymph nodes: the site of lymphodenopathies and lymphomas associated with human immunodeficiency virus (HIV) infection. Arch Pathol Lab Med 1988, 112:1224-1228.
28. Ulirsch RC, Jaffe ES: Sjögren's syndrome-like illness associated with the acquired immuno-deficiency syndrome-related complex. Hum Pathol 1987, 18:1063-1068.
29. Kornstein MJ, Parker GA, Mills AS: Immunohistology of the benign lymphoepithelial lesion in AIDS-related lymphadenopathy: a case report. Hum Pathol 1988, 19:1359-1361.
30. Labouyrie E, Merlio JPH, Beylot-Barry M, Delord B, Vergier B, Brossard G, Lacoste D, Beylot J, Leng B, Fleury H, et al.: Human immunodeficiency virus type 1 replication within cystic lympho-epithelial lesion of the salivary gland. Am J Clin Pathol 1993, 100:41-46.
31. Ioachim HL, Ryan JR: Salivary lymphadenopathy and HIV [letter]. Am J Clin Pathol 1994, 102:142.
32. Dwyer E, Itescu S, Winchester R: Characterization of the primary structure of T cell receptor β chains in cells infiltrating the salivary gland in the Sicca syndrome or HIV-1 infection. J Clin Invest 1993, 92:495-502.
33. DiGiuseppe JA, Wu T-C, Corio RL: Analysis of Epstein-Barr virus-encoded small RNA1 expression in benign lymphoepithelial salivary gland lesions. Mod Pathol 1994, 7:555-559.
34. Shibata D, Weiss LM, Nathwani BN, Brynes RK, Levine AM: Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma. Blood 1991, 77:1527-1533.
35. Gulley ML, Sargeant KP, Grider DJ, Eagan PA, Davey DD, Damm DD, Robinson RA, Vandersteen DP, McGuff HS, Banks PM: Lymphomas of the oral soft tissues are not preferentially associated with latent or replicative Epstein-Barr virus. Oral Surg Oral Med Oral Pathol 1995, 80:425-431. Latent Epstein-Barr virus infection was demonstrated in 70% of HIV-associated oral lymphomas, but only 19% of oral lymphomas in HIV-negative patients.
36. Auclair PL: Tumor-associated lymphoid proliferation in the parotid gland: a potential diagnostic pitfall. Oral Surg Oral Med Oral Pathol 1994, 77:19-26. A description of the histopathologic features of lymphoid proliferations associated with various benign and malignant neoplasms of the parotid gland. These morphologic observations should help pathologists to interpret correctly the nature of lymphoid infiltrates accompanying various epithelial neoplasms.