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Volumn 17, Issue 5, 1996, Pages 1093-1099

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by hamster, mouse and rat intestine: Relevance of species differences

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; ACETONE; CARBON 14; CARCINOGEN; ISOTHIOCYANIC ACID DERIVATIVE; OXOACID;

EID: 0029941167     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.5.1093     Document Type: Article
Times cited : (9)

References (45)
  • 1
    • 0028318304 scopus 로고
    • Metabolic activation and detoxification of tobacco-specific nitrosamines - A model for cancer prevention strategies
    • Hecht,S.S. (1994) Metabolic activation and detoxification of tobacco-specific nitrosamines - a model for cancer prevention strategies. Drug Metab. Rev., 26, 373-390.
    • (1994) Drug Metab. Rev. , vol.26 , pp. 373-390
    • Hecht, S.S.1
  • 2
    • 0025307929 scopus 로고
    • Investigations on the origin of tobacco-specific nitrosamines in mainstream smoke of cigarettes
    • Fischer,S., Spiegelhalder,B., Eisenbarth,J. and Preussmann,R. (1990) Investigations on the origin of tobacco-specific nitrosamines in mainstream smoke of cigarettes. Carcinogenesis, 11, 723-730.
    • (1990) Carcinogenesis , vol.11 , pp. 723-730
    • Fischer, S.1    Spiegelhalder, B.2    Eisenbarth, J.3    Preussmann, R.4
  • 3
    • 0026770463 scopus 로고
    • Carcinogenic tobacco-specific nitrosamines are present at unusually high levels in the saliva of oral snuff users in Sudan
    • Idris,A.M., Nair,J., Friesen,M., Ohshima,H., Brouet,I., Faustman,E.M. and Bartsch,H. (1992) Carcinogenic tobacco-specific nitrosamines are present at unusually high levels in the saliva of oral snuff users in Sudan. Carcinogenesis, 13, 1001-1005.
    • (1992) Carcinogenesis , vol.13 , pp. 1001-1005
    • Idris, A.M.1    Nair, J.2    Friesen, M.3    Ohshima, H.4    Brouet, I.5    Faustman, E.M.6    Bartsch, H.7
  • 4
    • 0001466176 scopus 로고
    • Improved methodology for the quantitative assessment of tobacco-specific N-nitrosamines in tobacco by supercritical fluid extraction
    • Prokopzcyk,B., Wu,M., Cox,J.E., Amin,A., Desai,D., Idris,A.M. and Hoffmann,D. (1995) Improved methodology for the quantitative assessment of tobacco-specific N-nitrosamines in tobacco by supercritical fluid extraction. J. Agric. Food Chem., 43, 916-922
    • (1995) J. Agric. Food Chem. , vol.43 , pp. 916-922
    • Prokopzcyk, B.1    Wu, M.2    Cox, J.E.3    Amin, A.4    Desai, D.5    Idris, A.M.6    Hoffmann, D.7
  • 5
    • 0027988016 scopus 로고
    • Smoking and lung cancer: Scientific challenges and opportunities
    • Wynder,E.L. and Hoffmann,D. (1994) Smoking and lung cancer: scientific challenges and opportunities. Cancer Res., 54, 5284-5295
    • (1994) Cancer Res. , vol.54 , pp. 5284-5295
    • Wynder, E.L.1    Hoffmann, D.2
  • 6
    • 0022828943 scopus 로고
    • Smokeless tobacco and cancer: An overview
    • Zaridze,D. and Peto,R. (eds), IARC Scientific Publication no. 74, IARC, Lyon, France
    • Muir,C.S. and Zaridze,D.G. (1986) Smokeless tobacco and cancer: an overview. In Zaridze,D. and Peto,R. (eds), Tobacco - A Major International Health Hazard. IARC Scientific Publication no. 74, IARC, Lyon, France pp. 35-44.
    • (1986) Tobacco - A Major International Health Hazard , pp. 35-44
    • Muir, C.S.1    Zaridze, D.G.2
  • 7
    • 0025147275 scopus 로고
    • Characterization of a glucuronide metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its dose-dependent excretion in the urine of mice and rats
    • Morse,M.A., Eklind,K.I., Touissant,M., Amin,S.G. and Chung,F.-L. (1990) Characterization of a glucuronide metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its dose-dependent excretion in the urine of mice and rats. Carcinogenesis, 11, 1819-1823.
    • (1990) Carcinogenesis , vol.11 , pp. 1819-1823
    • Morse, M.A.1    Eklind, K.I.2    Touissant, M.3    Amin, S.G.4    Chung, F.-L.5
  • 8
    • 0027154593 scopus 로고
    • Metabolism of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone in the Patas monkey: Pharmacokinetics and characterization of glucuronide metabolites
    • Hecht,S.S. et al. (1993) Metabolism of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone in the Patas monkey: pharmacokinetics and characterization of glucuronide metabolites. Carcinogenesis, 14, 229-236
    • (1993) Carcinogenesis , vol.14 , pp. 229-236
    • Hecht, S.S.1
  • 9
    • 0028200881 scopus 로고
    • Nicotine inhibits the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats
    • Richter,E. and Tricker,A.R. (1994) Nicotine inhibits the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats. Carcinogenesis, 15, 1061-1064.
    • (1994) Carcinogenesis , vol.15 , pp. 1061-1064
    • Richter, E.1    Tricker, A.R.2
  • 10
    • 0027438965 scopus 로고
    • Identification of 4-(methylnitrosamino)-1-[3-(6-hydroxypyridyl)]-1-butanone as a urinary metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rodents
    • Desai,D., Kagan,S.S., Amin,S., Carmella,S.G. and Hecht,S.S. (1993) Identification of 4-(methylnitrosamino)-1-[3-(6-hydroxypyridyl)]-1-butanone as a urinary metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rodents. Chem. Res. Toxicol., 6, 794-799.
    • (1993) Chem. Res. Toxicol. , vol.6 , pp. 794-799
    • Desai, D.1    Kagan, S.S.2    Amin, S.3    Carmella, S.G.4    Hecht, S.S.5
  • 11
    • 0020663028 scopus 로고
    • Comparative carcinogenicity in A/J-mice and metabolism by cultured mouse peripheral lung of N-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and their analogues
    • Castonguay,A., Lin,D., Stoner,G.D., Radok,P., Furuya,K., Hecht,S.S., Schut,H.A.J. and Klaunig,J.E. (1983) Comparative carcinogenicity in A/J-mice and metabolism by cultured mouse peripheral lung of N-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and their analogues. Cancer Res., 43, 1223-1229.
    • (1983) Cancer Res. , vol.43 , pp. 1223-1229
    • Castonguay, A.1    Lin, D.2    Stoner, G.D.3    Radok, P.4    Furuya, K.5    Hecht, S.S.6    Schut, H.A.J.7    Klaunig, J.E.8
  • 12
    • 0027273265 scopus 로고
    • Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice
    • Guo,Z., Smith,T.J., Wang,E., Eklind,K.I., Chung,F.L. and Yang,C.S. (1993) Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. Carcinogenesis, 14, 1167-1173.
    • (1993) Carcinogenesis , vol.14 , pp. 1167-1173
    • Guo, Z.1    Smith, T.J.2    Wang, E.3    Eklind, K.I.4    Chung, F.L.5    Yang, C.S.6
  • 13
    • 0026577195 scopus 로고
    • Inhibitory effects of diallyl sulfide on the metabolism and tumorigemcity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mouse lung
    • Hong,J.-Y. Wang,Z.Y., Smith,T.J., Zhou,S.Z., Shi,S., Pan,J. and Yang,C.S. (1992) Inhibitory effects of diallyl sulfide on the metabolism and tumorigemcity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mouse lung. Carcinogenesis. 13, 901-904.
    • (1992) Carcinogenesis , vol.13 , pp. 901-904
    • Hong, J.-Y.1    Wang, Z.Y.2    Smith, T.J.3    Zhou, S.Z.4    Shi, S.5    Pan, J.6    Yang, C.S.7
  • 14
    • 0027055359 scopus 로고
    • Effects of phenethylisothiccyanate, a Carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes, and nitrosamine metabolism in rats
    • Guo,Z., Smith,T.J., Wang,E., Sadrieh,N., Ma,Q., Thomas,P.E. and Yang,C.S. (1992) Effects of phenethylisothiccyanate, a Carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes, and nitrosamine metabolism in rats. Carcinogenesis, 13, 2205-2210.
    • (1992) Carcinogenesis , vol.13 , pp. 2205-2210
    • Guo, Z.1    Smith, T.J.2    Wang, E.3    Sadrieh, N.4    Ma, Q.5    Thomas, P.E.6    Yang, C.S.7
  • 15
    • 0026723431 scopus 로고
    • Effect of pregnancy and ethanol treatment on the metabolism of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by hamster liver and lung microsomes
    • Jorquera,R., Castonguay,A. and Schuller,H.M. (1992) Effect of pregnancy and ethanol treatment on the metabolism of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by hamster liver and lung microsomes. Drug Metab. Dispos., 20, 510-517.
    • (1992) Drug Metab. Dispos. , vol.20 , pp. 510-517
    • Jorquera, R.1    Castonguay, A.2    Schuller, H.M.3
  • 16
    • 0027412663 scopus 로고
    • Effect of tobacco smoke condensate on the metabolism of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by adult and fetal hamster microsomes
    • Jorquera,R., Castonguay,A. and Schuller,H.M. (1993) Effect of tobacco smoke condensate on the metabolism of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by adult and fetal hamster microsomes. Drug Metab. Dispos., 21, 318-324.
    • (1993) Drug Metab. Dispos. , vol.21 , pp. 318-324
    • Jorquera, R.1    Castonguay, A.2    Schuller, H.M.3
  • 17
    • 0026741674 scopus 로고
    • Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells
    • Smith,T.J., Guo,Z., Gonzalez,F.J., Guengerich,F.P., Stoner,G.D. and Yang,C.S. (1992) Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells. Cancer Res., 52, 1757-1763.
    • (1992) Cancer Res. , vol.52 , pp. 1757-1763
    • Smith, T.J.1    Guo, Z.2    Gonzalez, F.J.3    Guengerich, F.P.4    Stoner, G.D.5    Yang, C.S.6
  • 18
    • 0026793493 scopus 로고
    • Kinetics and enzyme involvement in the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butancme (NNK) in microsomes and its inhibition by isothiocyanates
    • Smith,T.J., Guo,Z., Hong,J.-Y. Ning,S.M., Thomas,P.E. and Yang,C.S. (1992) Kinetics and enzyme involvement in the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butancme (NNK) in microsomes and its inhibition by isothiocyanates. Carcinogenesis, 13, 1409-1414.
    • (1992) Carcinogenesis , vol.13 , pp. 1409-1414
    • Smith, T.J.1    Guo, Z.2    Hong, J.-Y.3    Ning, S.M.4    Thomas, P.E.5    Yang, C.S.6
  • 19
    • 0029145042 scopus 로고
    • Intestinal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats: Sexdifference, inducibility and inhibition by phenethylisothiocyanate
    • Schulze,J., Malone,A. and Richter,E. (1995) Intestinal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats: sexdifference, inducibility and inhibition by phenethylisothiocyanate. Carcinogenesis, 16, 1733-1740.
    • (1995) Carcinogenesis , vol.16 , pp. 1733-1740
    • Schulze, J.1    Malone, A.2    Richter, E.3
  • 21
    • 0026604162 scopus 로고
    • Effects of sulindac and oltipraz on the tumorigenicity of 4-(methylnitrosamino)-1 - (3-pyridyl)-1-butanone in A/J mouse lung
    • Pepin,P., Bouchard,L., Nicole,P. and Castonguay,A. (1992) Effects of sulindac and oltipraz on the tumorigenicity of 4-(methylnitrosamino)-1 - (3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis, 13, 341-348.
    • (1992) Carcinogenesis , vol.13 , pp. 341-348
    • Pepin, P.1    Bouchard, L.2    Nicole, P.3    Castonguay, A.4
  • 22
    • 0025311241 scopus 로고
    • The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is an active transplacental carcinogen in Syrian golden hamsters
    • Correa,E., Joshi,P.A., Castonguay,A. and Schuller,H.M. (1990) The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is an active transplacental carcinogen in Syrian golden hamsters. Cancer Res., 50, 3435-3438.
    • (1990) Cancer Res. , vol.50 , pp. 3435-3438
    • Correa, E.1    Joshi, P.A.2    Castonguay, A.3    Schuller, H.M.4
  • 23
    • 15844429618 scopus 로고
    • Transplacental carcinogenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at low dose levels in the hamster
    • Schuller,H.M., Lu,X.-C., Reichert,A. and Castonguay,A. (1992) Transplacental carcinogenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at low dose levels in the hamster. Proc. Am. Ass. Cancer Res., 33, 113.
    • (1992) Proc. Am. Ass. Cancer Res. , vol.33 , pp. 113
    • Schuller, H.M.1    Lu, X.-C.2    Reichert, A.3    Castonguay, A.4
  • 24
    • 0027240991 scopus 로고
    • Transplacental induction of pancreas tumors in hamsters by ethanol and the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Schuller,H.M., Jorquera,R., Reichert,A. and Castonguay,A. (1993) Transplacental induction of pancreas tumors in hamsters by ethanol and the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res., 53, 2498-2501.
    • (1993) Cancer Res. , vol.53 , pp. 2498-2501
    • Schuller, H.M.1    Jorquera, R.2    Reichert, A.3    Castonguay, A.4
  • 25
    • 0026598851 scopus 로고
    • Small intestinal cytochrome P450
    • Kaminsky,L.S. and Fasco,M. (1992) Small intestinal cytochrome P450. Crit. Rev. Toxicol., 21, 407-422.
    • (1992) Crit. Rev. Toxicol. , vol.21 , pp. 407-422
    • Kaminsky, L.S.1    Fasco, M.2
  • 26
    • 0022395913 scopus 로고
    • All-glass perfusator for investigation of the intestinal transport and metabolism of foreign compounds in vitro
    • Richter,E. and Strugala,G.J. (1985) All-glass perfusator for investigation of the intestinal transport and metabolism of foreign compounds in vitro. J. Pharmacol. Methods, 14, 297-304.
    • (1985) J. Pharmacol. Methods , vol.14 , pp. 297-304
    • Richter, E.1    Strugala, G.J.2
  • 27
    • 0023021653 scopus 로고
    • Intestinal metabolism of nitrosamines. 1. Transport and metabolism of six nitrosamines in isolated perfused rat small intestinal segments
    • Richter,E., Richter-Cooberg,U., Feng,X., Schulze,J. and Wiessler,M. (1986) Intestinal metabolism of nitrosamines. 1. Transport and metabolism of six nitrosamines in isolated perfused rat small intestinal segments. Carcinogenesis, 7, 1207-1213.
    • (1986) Carcinogenesis , vol.7 , pp. 1207-1213
    • Richter, E.1    Richter-Cooberg, U.2    Feng, X.3    Schulze, J.4    Wiessler, M.5
  • 28
    • 0023866905 scopus 로고
    • Intestinal first pass metabolism of nitrosamines. 2. Metabolism of N-nitrosodibutylamine in isolated perfused rat small intestinal segments
    • Richter,E., Zwickenpflug,W. and Wiessler,M. (1988) Intestinal first pass metabolism of nitrosamines. 2. Metabolism of N-nitrosodibutylamine in isolated perfused rat small intestinal segments. Carcinogenesis, 9, 499-506.
    • (1988) Carcinogenesis , vol.9 , pp. 499-506
    • Richter, E.1    Zwickenpflug, W.2    Wiessler, M.3
  • 29
    • 0023851278 scopus 로고
    • Intestinal first pass metabolism of nitrosamines. 3. Identification of metabolites of N-nitrosodiamylamine
    • Richter,E., Lorck,C. and Wiessler,M. (1988) Intestinal first pass metabolism of nitrosamines. 3. Identification of metabolites of N-nitrosodiamylamine. Carcinogenesis, 9, 507-509
    • (1988) Carcinogenesis , vol.9 , pp. 507-509
    • Richter, E.1    Lorck, C.2    Wiessler, M.3
  • 30
    • 0024458427 scopus 로고
    • Effects of alkyl chain length on the inhibition of NNK induced lung neoplasia in A/J mice by aralkyl isothiocyanates
    • Morse,M.A., Eklind,K.I., Amin,S.G., Hecht,S.S. and Chung,F.-L. (1989) Effects of alkyl chain length on the inhibition of NNK induced lung neoplasia in A/J mice by aralkyl isothiocyanates. Carcinogenesis, 10, 1757-1759.
    • (1989) Carcinogenesis , vol.10 , pp. 1757-1759
    • Morse, M.A.1    Eklind, K.I.2    Amin, S.G.3    Hecht, S.S.4    Chung, F.-L.5
  • 31
    • 0024589128 scopus 로고
    • Inhibition of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by phenethyl isothiocyanates
    • Morse,M.A., Wang,X.-A., Stoner,G.D., Mandal,S., Conran,P.B., Amin, S.G., Hecht,S.S. and Chung,F.-L. (1989) Inhibition of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by phenethyl isothiocyanates. Cancer Res., 49, 549-553
    • (1989) Cancer Res. , vol.49 , pp. 549-553
    • Morse, M.A.1    Wang, X.-A.2    Stoner, G.D.3    Mandal, S.4    Conran, P.B.5    Amin, S.G.6    Hecht, S.S.7    Chung, F.-L.8
  • 32
    • 0027325487 scopus 로고
    • Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation by dietary phenethyl isothiocyanate
    • Smith,T.J., Guo,Z., Li,C., Ning,S.M., Thomas,P.E. and Yang,C.S. (1993) Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation by dietary phenethyl isothiocyanate. Cancer Res., 53, 3276-3282.
    • (1993) Cancer Res. , vol.53 , pp. 3276-3282
    • Smith, T.J.1    Guo, Z.2    Li, C.3    Ning, S.M.4    Thomas, P.E.5    Yang, C.S.6
  • 33
    • 0023216177 scopus 로고
    • Formation of hemoglobin adducts upon treatment of F344 rats with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosonornicotine
    • Carmella,S.G. and Hecht,S.S. (1987) Formation of hemoglobin adducts upon treatment of F344 rats with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosonornicotine. Cancer Res., 47, 2626-2630.
    • (1987) Cancer Res. , vol.47 , pp. 2626-2630
    • Carmella, S.G.1    Hecht, S.S.2
  • 34
    • 0026615181 scopus 로고
    • Biliary excretion of 4-methylnitrosamino-(3-pyridyl)-1-butanone in the rat
    • Schulze,J., Richter,E., Binder,U. and Zwickenpflug,W. (1992) Biliary excretion of 4-methylnitrosamino-(3-pyridyl)-1-butanone in the rat. Carcinogenesis, 13, 1961-1965
    • (1992) Carcinogenesis , vol.13 , pp. 1961-1965
    • Schulze, J.1    Richter, E.2    Binder, U.3    Zwickenpflug, W.4
  • 35
    • 0024262907 scopus 로고
    • Induction of lung and exocrine pancreas tumors in F344 rats by tobaccospecific and areca nut-derived N-nitrosamines
    • Rivenson,A., Hoffmann,D., Prokopzcyk,B., Amin,S. and Hecht,S.S. (1988) Induction of lung and exocrine pancreas tumors in F344 rats by tobaccospecific and areca nut-derived N-nitrosamines. Cancer Res., 48, 6912-6917
    • (1988) Cancer Res. , vol.48 , pp. 6912-6917
    • Rivenson, A.1    Hoffmann, D.2    Prokopzcyk, B.3    Amin, S.4    Hecht, S.S.5
  • 36
    • 0027174948 scopus 로고
    • A study of tobacco Carcinogenesis - Effect of the fat content of the diet on the carcinogenic activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats
    • Hoffmann,D., Rivenson,A., Abbi,R. and Wynder,E.L. (1993) A study of tobacco Carcinogenesis - effect of the fat content of the diet on the carcinogenic activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. Cancer Res., 53, 2758-2761.
    • (1993) Cancer Res. , vol.53 , pp. 2758-2761
    • Hoffmann, D.1    Rivenson, A.2    Abbi, R.3    Wynder, E.L.4
  • 37
    • 0028080010 scopus 로고
    • Effects of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on N-nitrosobis(2-oxopropyl)amine (BOP)-initiated Carcinogenesis in hamsters
    • Furukawa,F., Nishikawa,A., Yoshimura,H., Mitsui.M., Imazawa,T., Ikezaki,S. and Takahashi,M. (1994) Effects of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on N-nitrosobis(2-oxopropyl)amine (BOP)-initiated Carcinogenesis in hamsters. Cancer Lett., 86, 75-82.
    • (1994) Cancer Lett. , vol.86 , pp. 75-82
    • Furukawa, F.1    Nishikawa, A.2    Yoshimura, H.3    Mitsui, M.4    Imazawa, T.5    Ikezaki, S.6    Takahashi, M.7
  • 38
    • 0026592561 scopus 로고
    • Dietary effects on cytochromesP450, xenobiotic metabolism, and toxicity
    • Yang,C.S., Brady,J.F. and Hong,J.Y. (1992) Dietary effects on cytochromesP450, xenobiotic metabolism, and toxicity. FASEB J., 6, 737-744
    • (1992) FASEB J. , vol.6 , pp. 737-744
    • Yang, C.S.1    Brady, J.F.2    Hong, J.Y.3
  • 39
    • 0023895342 scopus 로고
    • Expression of cytochrome P450b and P450e genes in small intestinal mucosa of rats following treatment with phenobarbital, polyhalogenated biphenyls, and organochlorine pesticides
    • Traber,P.G., ChianaleJ., Florence,R., Kim,K., Wojcik,E. and Gumucio,J.J. (1988) Expression of cytochrome P450b and P450e genes in small intestinal mucosa of rats following treatment with phenobarbital, polyhalogenated biphenyls, and organochlorine pesticides. J. Biol. Chem., 263, 9449-9455
    • (1988) J. Biol. Chem. , vol.263 , pp. 9449-9455
    • Traber, P.G.1    Chianale, J.2    Florence, R.3    Kim, K.4    Wojcik, E.5    Gumucio, J.J.6
  • 40
    • 0026714511 scopus 로고
    • Differential regulation of cytochromes P-450 genes along rat intestinal crypt-villus axis
    • Traber,P.G., Wang,W. and Yu,L. (1992) Differential regulation of cytochromes P-450 genes along rat intestinal crypt-villus axis. Am. J. Physiol., 263, G215-G233.
    • (1992) Am. J. Physiol. , vol.263
    • Traber, P.G.1    Wang, W.2    Yu, L.3
  • 42
    • 0021247752 scopus 로고
    • Intramucosal carcinoma of the small intestine arising in regional enteriitis (Crohn's disease). Report of a case studied for carcinoembryonic antigen and review of the literature
    • Perzin,K.H., Peterson,M., Castiglione,C.L., Fenoglio,D.M. and Wolff,M. (1984) Intramucosal carcinoma of the small intestine arising in regional enteriitis (Crohn's disease). Report of a case studied for carcinoembryonic antigen and review of the literature. Cancer, 54, 151-162.
    • (1984) Cancer , vol.54 , pp. 151-162
    • Perzin, K.H.1    Peterson, M.2    Castiglione, C.L.3    Fenoglio, D.M.4    Wolff, M.5
  • 43
    • 0022242889 scopus 로고
    • Pharmacokinetics of N-nitrosonornicotine and 4-methylnitrosamino-1-(3-pyridyl)-1-butanone in laboratory animals
    • Adams,J.D., LaVoie,E.J., O'Mara-Adams,K.J., Hoffmann,D., Carey,K.D. and Marshall,M.V. (1985) Pharmacokinetics of N-nitrosonornicotine and 4-methylnitrosamino-1-(3-pyridyl)-1-butanone in laboratory animals. Cancer Lett., 28, 195-201.
    • (1985) Cancer Lett. , vol.28 , pp. 195-201
    • Adams, J.D.1    LaVoie, E.J.2    O'Mara-Adams, K.J.3    Hoffmann, D.4    Carey, K.D.5    Marshall, M.V.6
  • 44
    • 0028032548 scopus 로고
    • Metabolism of a glucuronide conjugate of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone in rats
    • Atawodi,S.E.O., Michelsen,K. and Richter,E. (1994) Metabolism of a glucuronide conjugate of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone in rats. Arch. Toxicol., 69, 14-17.
    • (1994) Arch. Toxicol. , vol.69 , pp. 14-17
    • Atawodi, S.E.O.1    Michelsen, K.2    Richter, E.3
  • 45
    • 0027325487 scopus 로고
    • Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation by dietary phenethyl isothiocyanate
    • Smith,T.J., Guo,Z., Li,C., Ning,S.M., Thomas,P.E. and Yang,C.S. (1993) Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation by dietary phenethyl isothiocyanate. Cancer Res., 53, 3276-3282.
    • (1993) Cancer Res. , vol.53 , pp. 3276-3282
    • Smith, T.J.1    Guo, Z.2    Li, C.3    Ning, S.M.4    Thomas, P.E.5    Yang, C.S.6


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