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Kadakia SC, Kikendall JW, Maydonovitch C, Johnson LF: Effect of cigarette smoking on gastroesophageal reflux measured by 24-h ambulatory esophageal pH monitoring. Am J Gastroenterol 1995, 90:1785-1790. Using prolonged pH monitoring and controling for the pharmacologic half-life of nicotine, this study shows that cigarette smoking significantly increased the percentage of time that the pH was lower than 4 during the 24-hour study period. This increase occurred predominantly during the day while the patient was in the upright posture and was associated with a 114% rise in subjective complaints of heartburn.
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Mixed reflux of gastric and duodenal juices is more harmful to the esophagus than gastric juice alone
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Reliability of 24-hour home esophageal pH-monitoring in diagnosis of gastroesophageal reflux
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0029164726
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How well can quantitative 24-hour intraesophageal pH monitoring distinguish various degrees of reflux disease?
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Ghillebert G, Demeyere AM, Janssens J, VanTrappen G: How well can quantitative 24-hour intraesophageal pH monitoring distinguish various degrees of reflux disease? Dig Dis Sci 1995, 40:1317-1324. This study challenges the accepted values for sensitivity and specificity of prolonged pH monitoring. Although the authors demonstrate that this modality remains an excellent tool for characterizing patterns of reflux in patients with severe esophagitis, they also show that it becomes less effective in patients with mild to moderate esophageal reflux.
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Chronic cough and hoarseness in patients with severe gastroesophagsal reflux disease
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Simultaneous prolonged recordings of proximal and distal intraesophageal pH in children with gastroesophageal reflux disease and respiratory symptoms
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2 receptor antagonists showed that omeprazole therapy was effective for at least 5 years. Patients were noted to have increased serum gastrin levels and an increase of micronodular argyrophil cell hyperplasia and atrophic gastritis.
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