Ethanol consumption suppresses the IL2-induced proliferation of NK cells

Toxicology and Applied Pharmacology

Volumn 138, Issue 1, 1996, Pages 90-97

  Gallucci, R M ^a   Meadows, G G ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RECOMBINANT INTERLEUKIN 2;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOLYSIS; FEMALE; LYMPHOKINE ACTIVATED KILLER CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; SPLEEN CELL;

ANIMALIA; MURINAE;

EID: 0029940435     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0102     Document Type: Article

References (58)

1. Abdallah, R. M., Starkey, J. R., and Meadows, G. G. (1983). Alcohol and related dietary effects on mouse natural killer-cell activity. Immunology 50, 131-137.
2. Abdallah, R. M., Starkey, J. R., and Meadows, G. G. (1988). Toxicity of chronic high alcohol intake on mouse natural killer cell activity. Res. Commun. Chem. Pathol. Pharmacol. 59, 245-258.
3. Basista, M. H., Gavaler, J., Stieffenhofer, A., Love, K., Rosenblum, E., and Dindzans, V. J. (1993). Effects of ethanol on kupffer cell function. Alcoholism: Clin. Exp. Res. 17, 556-560.
4. Bermudez, L. E., and Young, L. S. (1991). Ethanol augments intracellular survival of Mycobacterium avium complex and impairs macrophage response to cytokines. J. Infect. Dis. 163, 1286-1292.
5. Biron, C. A., Byron, K. S., and Sullivan, J. L. (1989). Severe herpesvirus infections in an adolescent without natural killer cells. N. Engl. J. Med. 320, 1731-1735.
6. Blank, S. E., Duncan, D. A., and Meadows, G. G. (1991). Suppression of natural killer cell activity by ethanol consumption and food restriction. Alcoholism: Clin. Exp. Res. 15, 16-22.
7. Blank, S. E., Johansson, J.-O., Origines, M. M., and Meadows, G. G. (1992). Modulation of NK cell activity by moderate intensity endurance training and chronic ethanol consumption. J. Appl. Physiol. 72, 8-14.
8. Blank, S. E., Meadows, G. G., Pfister, L. J., and Gallucci, R. M. (1993). Natural killer cells and alcohol. In Advances in Biosciences. Alcohol, Drugs of Abuse, and Immunomodulation (AIDS) (R. R. Watson, Ed.), Vol. 86, pp. 79-90. Pergamon, England.
9. Blay, J. Y., Bertoglio, J., Fradelizi, D., and Chouaib, S. (1989). Functional interactions of IL2 and TNF in the differentiation of LGL into LAK effectors. Int. J. Cancer 44, 598-604.
10. Brodie, C., Domenico, J., and Gelfand, E. W. (1994). Ethanol inhibits early events in T-lymphocyte activation. Clin. Immunol. Immunopathol. 70, 129-136.
11. Chadha, K. C., Stadler, I., Albini, B., Nakeeb, S. M., and Harshad, T. R. (1992). Effect of alcohol on spleen cells and their functions in C57BL/ 6 mice. Alcohol 8, 481-485.
12. Chang, M. P., Norman, D. C., and Makinodan, T. (1990). Immunotoxicity of alcohol in young and old mice. I. In vitro suppressive effects of ethanol on the activities of T and B immune cells of aging mice. Alcoholism: Clin. Exp. Res. 14, 210-215.
13. Chang, M. P., and Norman, D. C. (1992). Mechanism of ethanol-mediated immunosuppression in mice: ethanol suppresses T-cell proliferation without affecting IL2 production and IL2 receptor expression. Int. J. Immunopharm, 14, 707-719.
14. Cohen, G. M., Sun, X. M., Snowden, R. T., Dinsdale, D., and Skilleter, D. N. (1992). Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem. J. 286, 331-334.
15. Cole, M. D. (1986). The myc oncogene: Its role in transformation and differentiation. Annu. Rev. Genet. 20, 361-384.
16. Datta, R., Sherman, M. L., and Kufe, D. W. (1990). Regulation of protooncogene and tumor necrosis factor gene expression by ethanol in HL-60 myeloid leukemia cells. Blood 76, 298-301.
17. Deaciuc, I. V., D'Souza, N. B., Bagby, G. J., Lang, C. H., and Spitzer, J. J. (1992). Effect of acute alcohol administration on TNF-alpha binding to neutrophils and isolated liver plasma membranes. Alcoholism: Clin. Exp. Res. 16, 533-538.
18. Diehl, A. M., Thorgeirsson, S. S., and Steer, C. J. (1990). Ethanol inhibits liver regeneration in rats without reducing transcripts of key protooncogenes. Gasteroenterology 99, 1105-1112.
19. Earnest, D. L., Abril, E. R., Jolley, C. S., and Eskelson, C. D. (1993). Kupffer cell activity and hepatic microvascular events after acute ethanol ingestion in mice. Hepatology 86, 181-190.
20. Ewald, S. J., and Shao, H. (1993). Ethanol increases apoptotic cell death of thymocytes in vitro. Alcoholism: Clin. Exp. Res. 17, 359-365.
21. Gallucci, R. M., Pfister, L. J., and Meadows, G. G. (1994). The effects of ethanol consumption on enriched natural killer cells from C57BL/6 mice. Alcoholism: Clin. Exp. Res. 18, 625-631.
22. Gallucci, R. M., and Meadows, G. G. (1995). Ethanol consumption reduces the cytolytic activity of lymphokine-activated killer cells. Alcoholism: Clin. Exp. Res. 19, 402-409.
23. Giovarelli, M., Santoni, A., Jemma, C., Musso, T., Giuffrida, A. M., Cavallo, G., Landolfo, S., and Forni, G. (1988). Obligatory role of IFN in induction of lymphokine-activated and T lymphocyte killer activity, but not in boosting of natural cytotoxicity. J. Immunol. 141, 2831-2836.
24. Itoh, K., Shiiba, K., Shimizu, Y., Suzuki, R., and Kumagai, K. (1985). Generation of activated killer (AK) cells by recombinant interleukin 2 (rIL2) in collaboration with interferon-γ (IFN-γ). J. Immunol. 134, 3124-3129.
25. Jerrells, T. R., Peritt, D., Marietta, C., and Eckardt, M. J. (1989). Mechanisms of suppression of cellular immunity induced by ethanol. Alcoholism: Clin. Exp. Res. 13, 490-493.
26. Jerrells, T. R., Perritt, D., Eckardt, M. J., and Marietta, C. (1990a). Alterations in interleukin-2 utilization by T-cells from rats treated with an ethanol-containing diet. Alcoholism: Clin. Exp. Res. 14, 245-249.
27. Jerrells, T. R., Smith, W., and Eckardt, M. J. (1990b). Murine model of ethanol-induced immunosuppression. Alcoholism: Clin. Exp. Res. 14, 546-550.
28. Jung, T., Schauer, U., Heusser, C., Neumann, C., and Rieger, C. (1993). Detection of intracellular cytokines by flow cytometry. J. Immunol. Methods 159, 197-207.
29. Kaplan, D. R. (1986). A novel mechanism of immunosuppression mediated by ethanol. Cell. Immunol. 102, 1-9.
30. MacGregor, R. R. (1986). Alcohol and immune defense. J. Am. Med. Assoc. 256, 1474-1479.
31. Meadows, G. G., Blank, S. E., and Duncan, D. D. (1989). Influence of ethanol consumption on natural killer cell activity in mice. Alcoholism: Clin. Exp. Res. 13, 476-479.
32. Meadows, G. G., Blank, S. E., and Duncan, D. A. (1990). Modulation of natural killer cell activity by alcohol consumption and nutritional status. In Prog. Clin. and Biol. Res. Vol 325. Alcohol, Immunosuppression and AIDS (D. Seminara, R. R. Watson, and A. Pawlowski, Eds.), pp. 181-190. A. R. Liss, New York.
33. Meadows, G. G., Wallendal, M., Kosugi, A., Wunderlich, J., and Singer, D. S. (1992). Ethanol induces marked changes in lymphocyte populations and natural killer cell activity in mice. Alcoholism: Clin. Exp. Res. 16, 474-479.
34. Meadows, G. G., and Blank, S. E. (1993). Modulation of natural killer cell activity by alcohol. In Alcohol, Immunity, and Cancer (R. Yirmiya and A. N. Taylor, Eds.), pp. 55-85. CRC Press, Boca Raton.
35. Minami, Y., Kono, T., Yamada, K., and Taniguchi, T. (1992). The interleukin-2 receptors: Insights into a complex signaling mechanism. Biochim. Biophys. Acta 1114, 163-177.
36. Miyazaki, T., Liu, Z. J., Kawahara, A., Minami, Y., Yamada, K., Tsujimoto, Y., Barsoumian, E. L., Perlmutter, R. M., and Taniguchi, T. (1995). Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81, 223-231.
37. Naume, B., Shalaby, R., Lesslauer, W., and Espevik, T. (1991). Involvement of the 55- and 75-kDa tumor necrosis factor receptors in the generation of lymphokine-activated killer cell activity and proliferation of natural killer cells. J. Immunol. 146, 3045-3048.
38. Nelson, S., Bagby, G., and Summer, W. R. (1989). Alcohol suppresses lipopolysaccharide-induced tumor necrosis factor activity in serum and lung. Life Sci. 44, 673-676.
39. Nelson, S., Bagby, G., Andresen, J., Nakamura, C., Shellito, J., and Summer, W. (1991). The effects of ethanol, tumor necrosis factor, and granulocyte colony-stimulating factor on lung antibacterial defenses. In Adv. Exp. Med. Biol. Drugs of Abuse, Immunity, and Immunodeficiency (H. Frideman, S. Specter, and T. W. Klein, Eds.), Vol. 288, pp. 245-253. Plenum, New York.
40. Norman, D. C., Chang, M. P., Wong, C. M. K., Branch, B. J., Castle, S., and Taylor, A. N. (1991). Changes with age in the proliferative response of splenic T cells from rats exposed to ethanol in utero. Alcoholism: Clin. Exp. Res. 15, 428-432.
41. O'Shea, J., and Ortaldo, J. R. (1992). The biology of natural killer cells: insights into the molecular basis of function. In The Natural Killer Cell. The Natural Immune System (C. E. Lewis and J. O'D. McGee, Eds.), pp. 1-40. IRL Press at Oxford Univ. Press, Oxford, England.
42. Okamura, S., Tanaka, T., Yamaga, S., Omori, F., and Niho, Y. (1991). The effects of recombinant human granulocyte-macrophage colony-stimulating factor on the induction of lymphokine-activated killer cells in vitro. Int. J. Immunopharm. 13, 587-593.
43. Ortaldo, J. R. (1989). Cytokine production by CD3-large granular lymphocytes. In Functions of the Natural Immune System (C. W. Reynolds and R. H. Wiltrout, Eds.), pp. 299-311. Plenum, New York.
44. Resnicoff, M., Sell, C., Ambrose, D., Baserga, R., and Rubin, R. (1993). Ethanol inhibits the autophosphorylation of the insulin-like growth factor (IGF-1) receptor and the IGF-1-mediated proliferation of 3T3 cells. J. Biol. Chem. 268, 21777-21782.
45. Roselle, G. A., Mendenhall, C. L., and Grossman, C. J. (1989). Ethanol and soluble mediators of host response. Alcoholism: Clin. Exp. Res. 13, 494-498.
46. Saad, A. J., and Jerrells, T. R. (1992). Flow cytometric and immunohistochemical evaluation of ethanol-induced changes in splenic and thymic lymphoid cell populations. Alcoholism: Clin. Exp. Res. 15, 796-803.
47. Saad, D. R., and Jerrells, T. R. (1993). The influence of age on blood alcohol levels and ethanol-associated immunosuppression in a murine model of ethanol consumption. Alcoholism: Clin. Exp. Res. 17, 382-388.
48. Schulze-Osthoff, K., Walczak, H., Droge, W., and Krammer, P. H. (1994). Cell nucleus and DNA fragmentation are not required for apoptosis. J. Cell Biol. 127, 15-19.
49. Shibuya, H., Yoneyama, M., Minomiya-Tsuji, N., Masumoto, K., and Taniguchi, T. (1992). IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc. Cell 70, 57-67.
50. Szabo, G., Verma, B., and Catalano, D. (1993). Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure: The role of impaired monocyte antigen presentation capacity and mediator production. J. Leukocyte Biol. 54, 534-544.
51. Trinchieri, G. (1991). Biology of natural killer cells. In Adv. Immunol. (F. J. Dixon, Ed.), Vol. 47, pp. 187-360. Academic Press, San Diego.
52. Trinchieri, G. (1992). Natural killer cells in haematopoiesis. In The Natural Killer Cell (C. E. Lewis and J. O'D. McGee, Eds.), pp. 41-65. Oxford Univ. Press, New York.
53. Ucker, D. S., Obermiller, P. S., Eckhart, W., Apgar, J. R., Berger, N. A., and Meyers, J. (1992). Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes. Mol. Cell. Biol. 12, 3060-3069.
54. Verma, B. K., Fogarasi, M., and Szabo, G. (1993). Down-regulation of tumor necrosis factor alpha activity by acute ethanol treatment in human peripheral blood monocytes. J. Clin. Immunol. 13, 8-22.
55. Wagner, F., Fink, R., Hart, R., Lersch, C., Dancygier, H., and Classen, M. (1992). Ethanol inhibits interferon-g secretion by human peripheral lymphocytes. J. Stud. Alcohol 53, 277-279.
56. Waltenbaugh, C., Mikszta, J., Ward, H., and Hsiung, L. (1994). Alteration of copolymer-specific humoral and cell-mediated immune responses by ethanol. Alcoholism: Clin. Exp. Res. 18, 1-7.
57. Whitmer-Pack, M. D., Olivier, W., Walinsky, J., Schuler, G., and Steinman, R. M. (1987). Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J. Exp. Med. 166, 1484-1498.
58. Yeralan, O., and Jones, J. M. (1990). Effects in vitro of ethanol and acetaldehyde on natural killer activity from rats. In Prog. Biol. Res. Vol 325. Alcohol, Immunomodulation, and AIDS (D. Seminara, R. R. Watson, and A. Pawlowski, Eds.), pp. 165-172. A. R. Liss, New York.