Oxytocin is hydrolyzed by an enzyme in human placenta that is identical to the oxytocinase of pregnancy serum

Peptides

Volumn 17, Issue 2, 1996, Pages 257-261

  Naruki, M ^a   Mizutani, Shigehiko ^a   Goto, K ^a   Tsujimoto, M ^b   Nakazato, H ^b   Itakura, A ^a   Mizuno, K ^a   Kurauchi, O ^a   Kikkawa, F ^a   Tomoda, Y ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SUNTORY LTD   (Japan)

Author keywords

Bestatin; Immunotitration; Oxytocin; Oxytocinase; Placental leucine aminopeptidase (P LAP)

Indexed keywords

BESTATIN; CYSTYL AMINOPEPTIDASE; CYTOSOL AMINOPEPTIDASE; OXYTOCIN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; NORMAL HUMAN; PLACENTA; PRIORITY JOURNAL;

EID: 0029940180     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/0196-9781(95)02124-8     Document Type: Article

References (27)

1. Bossmar, T.; Akerlund, M.; Fantoni, G.; Szamatowicz, J.; Melin, P.; Maggi, M. Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human pregnancy: Effects of the oxytocin antagonist atosiban. Am. J. Obstet. Gynecol. 171:1634-1642; 1994.
2. Burbach, J. P.; Lebouille, J. L. M. Proteolytic conversion of arginine-vasopressin and oxytocin by brain synaptic membranes. J. Biol. Chem. 258:1487-1494; 1983.
3. Dawood, M. Y.; Wang, C. F.; Gupta, R.; Fuchus, F. Fetal contribution of oxytocin in human parturition. Obstet. Gynecol. 52:205-208; 1978.
4. Fekete, K. Beiträge zur physiologie der Gravidität. Endokrinologie 7:364-369; 1930.
5. Fuchs, A. R.; Helmer, H.; Behrens, O.; et al. Oxytocin and bovine parturition: A steep rise in endometrial oxytocin receptors at onset of labour. Biol. Reprod. 47:937-944; 1992.
6. Hooper, K. C.; Jessup, D. C. The distribution of enzymes destroying oxytocin and vasopressin in human placenta. J. Physiol. 146:539-549; 1959.
7. Ishida, Y.; Fujita, T; Asai, N. New detection and separation method for amino acids by high-performance liquid chromatography. J. Chromatogr. 204:143-148; 1981.
8. Kimura, T.; Tanizawa, O.; Mon, K.; Brownstein, M. J.; Okayama, H. Structure and expression of a human oxytocin receptor. Nature 356:526-529; 1992.
9. Koida, M.; Walter, R. Postproline cleaving enzyme; purification of this endopeptidase by affinity chromatography. J. Biol. Chem. 251:7593-7599, 1976.
10. Kumaresan, P.; Anadarangam, P. B.; Dianzon, W.; Vasicka A. Plasma oxytocin levels during human pregnancy and labor as determined by radioimmunoassay. Am. J. Obstet. Gynecol. 119:215-223; 1974.
11. Lalu, K.; Lampero, S.; Vanna-Prettula, T. Characterization of three aminopeptidases purified from maternal serum. Biochim. Biophys. Acta 873:190-197; 1986.
12. Melin, P. Oxytocin antagonists and their therapeutic use. Regul. Pept. 45:285-288; 1993.
13. Mizutani, S.; Hayakawa, H.; Akiyama, H.; et al. Simultaneous determinations of plasma oxytocin and serum placental leucine aminopeptidase (P-LAP) during late pregnancy. Clin. Biochem. 15:141-145; 1982.
14. Mizutani, S.; Sumi, S.; Oka, K.; et al. In vitro degradation of oxytocin by pregnancy serum, placental subcellular fractions and purified placental aminopeptidases. Exp. Clin. Endocrinol. 86:310-316; 1985.
15. Mizutani, S.; Kurauchi, O.; Yamada, R.; Narita, O.; Tomoda, Y. Effects of bestatin, its related compound, puromycin and bactracin on human oxytocinase and human microsomal placental leucine aminopeptidase. IRCS Med. Sci. 14:270-271; 1986.
16. Mizutani, S.; Tomoda, Y. Oxytocinase: Placental cystine aminopeptidase or placental leucine aminopeptidase (P-LAP). Semin. Reprod. Endocrinol. 10:146-153; 1992.
17. Mizutani, S.; Yokosawa, H.; Tomoda, Y. Degradation of oxytocin by the human placenta: Effect of selective inhibitors. Acta Endocrinol. (Copenh.) 127:76-80; 1992.
18. Oosterbaan, H. P.; Swaab, D. F. Amniotic oxytocin and vasopressin in relation to human fetal development and labour. Early Hum. Dev. 19:253-262; 1989.
19. Oya, M.; Wakabayashi, T.; Yoshino, M; Mizutani, S. Subcellular distribution and electrophoretic behaviour of aminopeptidase in human placenta. Physiol. Chem. Phys. 8:327-335; 1976.
20. Page, E. W. The value of plasma pitocinase determinations in obstetrics. Am. J. Obstet. Gynecol. 52:1014-1022; 1946.
21. Ryden, G. Cystine aminopeptidase and oxytocinase activity in pregnancy. Acta Obstet. Gynecol. Scand. 45(Suppl. 3):5-105; 1966.
22. Sjoholm, I.; Yman, L. Degradation of oxytocin, lysine-vasopressin, angiotensin II and angiotensin II-amide by oxytocinase (cystine aminopeptidase). Acta Pharm. Suecica 4:65-76; 1967.
23. Stancampiano, R.; Meus, M. R.; Argiolas, A. Proteolytic conversion of oxytocin by brain synaptic membranes: Role of aminopeptidases and endopeptidases. Peptides 12:1119-1125; 1991.
24. Stephenson, S. L.; Kenny, A. J. Metabolism of neuropeptides. Hydrolysis of the angiotensins, bradykinin, substance P and oxytocin by pig kidney microvillar membranes. Biochem. J. 24:237-247; 1987.
25. Suda, H.; Aoyagi, T.; Takeuchi, T.; Umezawa, H. Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomer. Arch. Biochem. Biophys. 177:196-200; 1976.
26. Tsujimoto, M.; Mizutani, S.; Adachi, H.; Kimura, M.; Nakazato, H.; Tomoda, Y. Identification of human placental leucine aminopeptidase as oxytocinase. Arch. Biochem. Biophys. 292:388-392; 1992.
27. Watkins, W. B.; Small, C. W. Immunologic inactivation of human pregnancy serum oxytocinase activity. Am. J. Obstet. Gynecol. 113:973-978; 1972.