Slow intestinal transit: A motor disorder contributing to cholesterol gallstone formation in the ground squirrel

Hepatology

Volumn 23, Issue 6, 1996, Pages 1664-1672

  Xu, Qi Wei ^a   Scott, R Brent ^a   Tan, Daimen T M ^a   Shaffer, Eldon A ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b FOOTHILLS HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETHANECHOL; BILE SALT; CHOLECYSTOKININ; CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL DIET; CHOLESTEROL STONE; CONTROLLED STUDY; GALLSTONE; GAS LIQUID CHROMATOGRAPHY; INTESTINE FUNCTION DISORDER; INTESTINE MUSCLE; INTESTINE TRANSIT TIME; LIPID TRANSPORT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; SQUIRREL;

EID: 0029939493     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v23.pm0008675191     Document Type: Article

References (18)

1. Grundy SM, Metzger AL, Adler RD. Mechanisms of lithogenic bile formation in American Indian women with cholesterol gallstones. J Clin Invest 1972;51:3026-3043.
2. Shaffer EA, Small DM. Biliary lipid secretion in cholesterol gallstone disease: The effect of cholecystectomy and obesity. J Clin Invest 1977;59:828-840.
3. Pomeranz IS, Shaffer EA. Abnormal gallbladder emptying in a subgroup of patients with gallstones. Gastroenterology 1985;88:787-791.
4. Behar J, Lee KY, Thompson WR, Biancani P. Gallbladder contraction in patients with pigment and cholesterol stones. Gastroenterology 1989;97:1479-1484.
5. Paumgartner G, Sauerbruch T. Gallstones: pathogenesis. Lancet 1991;338:1117-1121.
6. Shaffer EA. Abnormalities in gallbladder function in cholesterol gallstone disease: bile and blood, mucosa and muscle: the list lengthens. Gastroenterology 1992;102:1808-1812.
7. LaMont JT, Afdhal NH. Biliary tract. Current Opinion in Gastroenterology 1993;9:787-790.
8. LaMorte WW. Biliary motility and abnormalities associated with cholesterol cholelithiasis. Current Opinion in Gastroenterology 1993;9:810-816.
9. Hardison WGM, Tomaszewski N, Grundy SM. Effect of acute alterations in small bowel transit time upon the biliary excretion rate of bile acids. Gastroenterology 1979;76:568-574.
10. Everson GT, Lawson MJ, McKinley C. Gallbladder and small intestinal regulation of biliary lipid secretion during intraduodenal infusion of standard stimuli. J Clin Invest 1983;71:596-603.
11. O'Donnell LJD, Wilson P, Guest P, Catnach SM, Mclean A, Wickham JEA, Pairclough PD. Indomethacin and postprandial gall-bladder emptying. Lancet 1992;339:269-270.
12. Roslyn JJ, DenBesten L, Pitt H, Kuchenbecker S, Polarek JW. Effect of cholecystokinin on gallbladder stasis and cholesterol gallstone formation. J Surg Res 1981;30:200-204.
13. Xu Q-W, Shaffer EA. Cisapride improves gallbladder contractility and bile lipid composition in an animal model of gallstone disease. Gastroenterology 1993;105:1184-1191.
14. Carey MC, Cahalane MJ. Enterohepatic circulation. In: Arias IM, ed. The Liver: Biology and Pathobiology. Ed 2. New York: Raven, 1988:573-616.
15. Ryan JP. Motility of the gallbladder and biliary tree. In: Johnson LR, ed. Physiology of the gastrointestinal tract. Ed 2. New York: Raven Press, 1987:695-721.
16. Heaton KW, Emmett PM, Symes CL, Braddon FEM. An explanation for gallstones in normal-weight women: slow intestinal transit. Lancet 1993;341:8-10.
17. Shoda J, He B-F, Tanaka N, Matsuzaki Y, Osuga T, Yamamori S, Miyazaki H, Sjovall J. Increase of deoxycholate in supersaturated bile of patients with cholesterol gallstone disease and its correlation with de novo synthesis of cholesterol and bile acids in liver, gallbladder emptying and small intestinal transit. HEPATOLOGY 1995;21:1291-1302.
18. Dowling RH, Hussaini SH, Murthy GM, Besser GM, Wass JAH. Gallstones during octreotide therapy. Metabolism 1992;41:22-33.