In vitro inhibition of membrane-mediated calcification by novel phosphonates

Calcified Tissue International

Volumn 58, Issue 5, 1996, Pages 347-354

  Skrtic, D ^a,b   Eidelman, N ^a   Golomb, G ^c   Breuer, E ^c   Eanes, E D ^a  

^a NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^b RUDER BO KOVI INSTITUTE   (Croatia)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Bone disorders; Calcium metabolism disorders; Geminal bisphosphonates; Hydroxyapatite

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCIUM ION; CALCIUM PHOSPHATE; CHOLESTEROL; CLODRONIC ACID; DICETYL PHOSPHATE; ETIDRONIC ACID; HYDROXYAPATITE; LIPOSOME; PAMIDRONIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHONIC ACID DERIVATIVE;

ARTICLE; CALCIFICATION; CALCIUM METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; IN VITRO STUDY; METABOLIC BONE DISEASE; MODEL; OSTEOPOROSIS; PAGET BONE DISEASE; PRIORITY JOURNAL;

APATITES; CALCIFICATION, PHYSIOLOGIC; CALCIUM; CELL MEMBRANE; LIPOSOMES; MOLECULAR STRUCTURE; PHOSPHONIC ACIDS;

EID: 0029939414     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900057     Document Type: Article

References (34)

1. Fleisch H (1991) Bisphosphonates: pharmacology and use in the treatment of tumor-induced hypercalcaemia and metastatic bone disease. Drugs 42:919-944
2. Liens D, Delmas PD, Meunier PJ (1994) Long-term effect of intravenous pamidronate in fibrous dysplasia of bone. Lancet 343:953-954
3. Rizzoli R, Stoermann C, Ammann P, Bonjour JP (1994) Hypercalcemia and hyperosteolysis in vitamin D intoxication: effects of clodronate therapy. Bone 15:193-198
4. Fleisch H (1994) The use of bisphosphonates in osteoporosis. Br J Clin Pract 48:323-326
5. Fleisch H (1993) New bisphosphonates in osteoporosis. Osteoporos Int 3(suppl 2):S15-S22
6. Fleisch H (1995) Bisphosphonates in bone diseases. From the laboratory to the patient. Parthenon Publishing Group, Pearl River, NY
7. Fleisch H, Russell RGG, Biaz S, Muhlbauer RC, Williams DA (1970) The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo. Eur J Clin Invest 1:12-18
8. Francis MD, Russell RGG, Fleisch H (1969) Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo. Science 165:1264-1266
9. Hansen NM Jr, Felix R, Biaz S, Fleisch H (1976) Aggregation of hydroxyapatite crystals. Biochim Biophys Acta 451:549-559
10. Boskey AL, Goldberg MR, Posner AS (1979) Effect of diphosphonates on hydroxyapatite formation induced by calcium-phospholipid-phosphate complexes. Calcif Tissue Int 27:83-88
11. Skrtic D, Eanes ED (1994) Effect of 1-hydroxyethylidene-1,1-bisphosphonate on membrane-mediated calcium phosphate formation in model liposomal suspensions. Bone Miner 26: 219-229
12. 32P, uptake and mineralization by matrix-vesicle enriched fractions and by hydroxyapatite. Bone 6:307-312
13. Morris DC, Andersen HC, Yoshikawa H, Nakahara H, Takaoka K, Ono K (1990) Matrix vesicle calcification of ectopically induced osteoid tissue in 1-hydroxyethylidcne-1,1-bisphosphonate (HEBP)-treated mice. Bone 11:281-286
14. Anderson H (1980) Calcification processes. Pathol Annu 15: 45-75
15. Boskey A (1981) Current concepts of the physiology and biochemistry of calcification. Clin Orthop Rel Res 157:225-257
16. Wuthier R (1982) A review of the primary mechanisms of endochondral calcification with special emphasis on the role of cells, mitochondria, and matrix vesicles. Clin Orthop Rel Res 169:219-242
17. Kim KM (1976) Calcification of matrix vesicles in human aortic valve and aortic media. Federation Proc 35:156-162
18. Francis MD, Martodam RR (1983) Chemical, biochemical and medicinal properties of diphosphonates. In: Hildebrand RL (ed) The role of phosphonates in living systems. CRC Press, Boca Raton, FL, p 55
19. Fleisch H (1987) Bisphosphonates - history and experimental basis. Bone 8:23-28
20. Golomb G, Schlossman A, Eitan Y, Saadeh H, Van Gelder JM, Breuer E (1992) In vitro and in vivo anticalcification effects of novel bishydroxyiminophosphonates. J Pharm Sci 81:1004-1007
21. Golomb G, Schlossman A, Saadeh H, Levi M, Van Gelder JM, Breuer E (1992) Bisacylphosphonates inhibit hydroxyapatite formation and dissolution in vitro and dystrophic calcification in vivo. Pharm Res 9:143-148
22. Van Gelder JM, Breuer E, Ornoy A, Schlossman A, Patlas N, Golomb G (1995) Anticalcification and antiresorption effects of bisacylphosphonates. Bone 16(5):511-520
23. Eanes ED, Hailer AW, Costa J (1984) Calcium phosphate formation in aqueous suspensions of multilamellar liposomes. Calcif Tissue Int 36:421-430
24. Eanes ED, Heywood BR (1989) Liposome technology in biomineralization research. In: Myers HM (ed) New technology in oral research. S. Karger, Basel, Switzerland, p 54
25. Karaman R, Goldblum A, Breuer E, Leader H (1989) Acylphosphonic acids and methyl hydrogen acylphosphonates. Physical and chemical properties and theoretical calculations. J Chem Soc Perkin Trans I 765-774
26. Breuer E, Golomb G, Schlossman A (1994a) US Patent #5, 312, 954: bis- and tetrakis-phosphonates useful for treating calcium-related disorders. May 17, 1994
27. Eanes ED, Hailer AW (1987) Calcium phosphate precipitation in aqueous solutions of phosphatidylserine-containing anionic liposomes. Calcif Tissue Int 40:43-48
28. Skrtic D, Eanes ED (1992) Effect of different phospholipidcholesterol membrane compositions on liposome-mediated formation of calcium phosphate. Calcif Tissue Int 50:253-260
29. Meyer JL, Nancollas GH (1973) The influence of multidentate organic phosphonates on the crystal growth of hydroxyapatite. Calcif Tissue Res 13:295-303
30. 2O: implications for polynuclear complex formation. J Phys Chem 76(9):1304-1310
31. Nardelli M, Pelizzi G, Stabiano C, Zucchi E (1983) Structural study of metal binding of gem-diphosphonates, bone growth regulators. Inorg Chem Acta 80:259-271
32. Szoka J, Papahadjopoulos D (1980) Comparative properties and methods of preparation of lipid vesicles (liposomes). Ann Rev Biophys Bioeng 9:467-508
33. Nylen MU, Eanes ED, Termine JD (1972) Molecular and ultrastructural studies of non-crystalline calcium phosphates. Calcif Tissue Res 9:95-108
34. Levy RJ, Schoen FJ, Levy JT, Nelson AC, Howard SL, Oshry LJ (1983) Biologic determinants of dystrophic calcification and osteocalcin deposition in glutaraldehyde-preserved porcine aortic valve leaflets implanted subcutaneously in rats. Am J Pathol 113:142-155