Hyperglycemia-induced latent scurvy and atherosclerosis: The scorbutic-metaplasia hypothesis

Medical Hypotheses

Volumn 46, Issue 2, 1996, Pages 119-129

  Price, K D ^a   Price, C S C ^b   Reynolds, R D ^c  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; COLLAGEN; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN;

ARTICLE; ASCORBIC ACID DEFICIENCY; ATHEROSCLEROSIS; HUMAN; HYPERGLYCEMIA; HYPOTHESIS; PRIORITY JOURNAL; SCURVY;

EID: 0029939218     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(96)90011-0     Document Type: Article

References (22)

1. Ross R. Factors influencing atherogenesis. In: Schlant R C, Alexander R W, eds. The Heart. Arteries and Veins, 8th edn. New York: McGraw-Hill, Inc. 1994: 989-1008.
2. Duguid J B. Diet and coronary disease. Lancet 1954; i: 891-895.
3. Steinberg D, Parthasarathy S, Carew T E, Khoo J C, Witztum J L. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989; 320: 915-924.
4. Esterbauer H, Gebicki J, Puhl H, Jürgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Rad Biol Med 1992; 13: 341-390.
5. Gaziano J M, Manson J E, Buring J E, Hennekens C H. Dietary antioxidants and cardiovascular disease. Ann NY Acad Sci 1992; 669: 249-259.
6. Jialal I, Grundy S M. Influence of antioxidant vitamins on LDL oxidation. Ann NY Acad Sci 1992; 669: 237-247.
7. Gey K F. Vitamin E and other essential antioxidants regarding coronary heart disease: risk assessment studies. In: Packer L, Fuchs J, eds. Vitamin E in Health and Disease. New York: Marcel Dekker, Inc, 1993: 589-633.
8. Reynolds R D. Vitamin supplements: current controversies. J Am Coll Nutr 1994; 13: 118-126.
9. Weser E, Young E A. Nutrition and internal medicine. In: Stein J H, ed. Internal Medicine, 3rd edn. Boston: Little, Brown and Company, 1990: 400-420.
10. Hess A F. Subacute and latent infantile scurvy. JAMA 1917; 68: 235-239.
11. Höjer J A. Studies in scurvy. Acta Pediat 1924; 3(Suppl): 1-278.
12. Rinehart J F, Mettier S R. The joints in experimental scurvy and in scurvy with superimposed infection, with a consideration of the possible relation of scurvy to rheumatic fever. Am J Pathol 1933; 9: 952-955.
13. Ginter E. Marginal vitamin C deficiency, lipid metabolism, and atherogenesis. In: Paoletti R, Kritchevsky D, eds. Advances in Lipid Research, vol. 16. New York: Academic Press, 1978: 167-220.
14. National Research Council. Recommended Dietary Allowances, 10th edn. Washington, DC: National Academy Press, 1989.
15. Levene C I. Collagen in arteriosclerosis. In: Jones R J, ed. Evolution of the Atherosclerotic Plaque. Chicago: University of Chicago Press, 1963: 235-242.
16. Findlay GM. The blood and blood-vessels in guinea-pig scurvy. J Path Bact 1921; 24: 446-453.
17. Taylor S. Scurvy and carditis. Lancet 1937; i: 973-979.
18. Willis G C. The reversibility of atherosclerosis. Can Med Assoc J 1957; 77: 106-109.
19. Fujinami T, Okado K, Senda K, Sugimura M, Kishikawa M. Experimental atherosclerosis with ascorbic acid deficiency. Jpn Circ J 1971; 35: 1559-1565.
20. Satinder A K S, Majumdar S, Chakravarti R N. Effect of ascorbic acid deficiency on the development of experimental atherosclerosis. Indian J Med Res 1987; 86: 351-360.
21. Rath M, Pauling L. Hypothesis: lipoprotein(a) is a surrogate for ascorbate. Proc Natl Acad Sci USA 1990; 87: 6204-6207.
22. Clemetson C A B. Vitamin C. Boca Raton, FL: CRC Press, 1989.