Role of negative regulation in promoter specificity of the homologous transcriptional activators Ace2p and Swi5p

Molecular and Cellular Biology

Volumn 16, Issue 4, 1996, Pages 1746-1758

  Dohrmann, Paul R ^a,b   Voth, Warren P ^a   Stillman, David J ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; REGULATOR PROTEIN; ZINC FINGER PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL CYCLE; DELETION MUTANT; GENE EXPRESSION REGULATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; YEAST;

EID: 0029939202     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.4.1746     Document Type: Article

References (47)

1. Alani, E., L. Cao, and N. Kleckner. 1987 A method for gene disruption that allows repeated use ot URA3 selection in the construction of multiply disrupted yeast strains Genetics 116:541-545.
2. Ausubel, F. M., R. Brent, R. E. Kingston, D. E. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1987 Current protocols in molecular biology John Wiley & Sons, New York
3. Boeke, J. D., F. LaCroute, and G. R. Fink. 1984. A positive selection for mutants lacking orotidine-5′-phosphate decarboxylasc activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet. 197:345-346.
4. Brazas, R. M., and D. J. Stillman. 1993. Identification and purification of a protein that binds DNA cooperatively with the yeast SWI5 protein Mol. Cell. Biol. 13:5524-5537.
5. Brazas, R. M., and D. J. Stillman. 1993. The Swi5 zinc finger and the Grf10 homeodomain proteins bind DNA cooperatively at the yeast HO promoter. Proc. Natl Acad. Sci. USA 90:11237-11241.
6. Breeden, L., and K. Nasmyth. 1985. Regulation of the yeast HO gene. Cold Spring Harbor Symp Quant. Biol. 50:643-650.
7. Breeden, L., and K. Nasmyth. 1987. Cell cycle control of the yeast HO gene. cis- and trans-acting regulators. Cell 48:389-397.
8. Butler, G., and D. J. Thiele. 1991. ACE2, an activator of yeast metallothionein expression which is homologous to SWI5. Mol. Cell. Biol. 11:476-485.
9. Chong, J. A., J. Tapia-Ramierez, S. Kim, J. J. Toledo-Aral, V. Zheng, M. C. Boutros, Y. M. Altshuller, M. A. Frohman, S. D. Kraner, and C. Mandel. 1995 REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80:949-957.
10. Chung, C. T., and R. H. Miller. 1988. A rapid and convenient method for the preparation and storage of competent bacterial cells. Nucleic Acids Res 16: 3580
11. Cleary, M. A., S. Stern, M. Tanaka, and W. Herr. 1993. Differential positive control by Oct-1 and Oct-2: activation of a transcriplionally silent motif through Oct-1 and VP16 corecruitment. Genes Dev. 7:72-83.
12. Cowell, I. G. 1994. Repression versus activation in the control of gene transcription. Trends Biochem. Sci. 19:38-42.
13. Dohrmann, P. R. 1994. Transcriptional regulation by the ACE2 and SWI5 activators in yeast. Ph.D dissertation. University of Utah, Salt Lake City
14. Dohrmann, P. R., G. Butler, K. Tamai, S. Dorland, J. R. Greene, D. J. Thiele, and D. J. Stillman. 1992 Parallel pathways of gene regulation, the homologous regulators SWI5 and ACE2 differentially control transcription of HO and chitinase. Genes Dev. 6:93-104
15. Goutte, C., and A. D. Johnson. 1993 Yeast a1 and α2 homeodomain proteins form a DNA-binding activity with properties distinct from those of either protein J Mol. Biol 233:359-371.
16. Guarente, L., and E. Hoar. 1984. Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the "TATA box." Proc Natl. Acad. Sci. USA 81: 7860-7864.
17. Guarente, L., B. Lalonde, P. Gifford, and E. Alani. 1984. Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae. Cell 36:503-511.
18. Hermes, J. D., S. M. Parekh, S. C. Blackow, H. Koster, and J. R. Knowles. 1989. A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligo-deoxyribonucleotide primers. Gene 84:143-151
19. Herschbach, B. M., and A. D. Johnson. 1993. Transcriptional repression in eukaryotes. Annu. Rev. Cell Biol. 9:479-509
20. Jiang, Y. W., and D. J. Stillman. 1992. Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae. Mol. Cell. Biol. 12:4503-4514.
21. Jiang, Y. W., and D. J. Stillman. 1995. Regulation of HIS4 expression by the Saccharomyces cerevisiae SIN4 transcriptional regulator Genetics 140:103-114.
22. Keleher, C. A., S. Pass more, and A. D. Johnson. 1989. Yeast repressor α2 binds to its operator cooperatively with yeast protein Mcm1. Mol. Cell. Biol. 9:5228-5230.
23. Keleher, C. A., M. J. Redd, J. Schultz, M. Carlson, and A. D. Johnson. 1992. Ssn6/Tup1 is a general repressor of transcription in yeast. Cell 68:709-719.
24. Kuranda, M. J., and P. W. Rabbins. 1991. Chitinase is required for cell separation during growth of Saccharomyces cerevisiae. J. Biol. Chem. 266: 19758-19767.
25. Laughon, A. 1991. DNA binding specificity of homeodomains. Biochemistry 30:11357-11372.
26. Lawrence, C. W. 1991 Classical mutagenesis techniques. Methods Enzymol. 194:273-281.
27. Leuther, K. K., J. M. Salmeron, and S. A. Johnston. 1993. Genetic evidence that an activation domain of GAL4 does not require acidity and may form a β sheet. Cell 72:575-585.
28. Levine, M., and J. L. Manley. 1989. Transcriptional repression of eukaryotic promoters Cell 59:405-408.
29. 28a. McBride, H., and D. J. Stillman. Unpublished observations.
30. Miles, J., and T. Formosa. 1992. Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase α, acts in DNA metabolism in vivo. Mol. Cell Biol. 12:5724-5735.
31. Myers, A. M., A. Tzagoloff, D. M. Kinney, and C. J. Lusty. 1986. Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions. Gene 45:299-310.
32. Nasmyth, K., G. Adolf, D. Lydall, and A. Seddon. 1990 The identification of a second ceil cycle control on the HO promoter in yeast: cell cycle regulation of SWI5 nuclear entry. Cell 62:631-647
33. Pavletich, N. P., and C. O. Pabo. 1991. Zinc finger-DNA recognition Crystal structure of a Zif268-DNA complex at 2.1 Å. Science 252:809-817.
34. Renkawitz, R. 1990. Transcriptional repression in eukaryotes. Trends Genet. 6:192-197.
35. Rothstein, R. 1991. Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194:281-302.
36. Sherman, F. 1991. Getting started with yeast. Methods Enzymol. 194:1-21.
37. Sherman, F., G. R. Fink, and J. B. Hicks. 1986. Methods in yeast genetics. Cold Spring Harbor Laboratory. Plainview, N.Y.
38. Sikorski, R. S., and J. D. Boeke. 1991. In vitro mutagenesis and plasmid shuffling: from cloned gene to mutant yeast. Methods Enzymol. 194:302-318.
39. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
40. Stillman, D. J., S. Dorland, and Y. Yu. 1994. Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SWI5 transcriptional activator. Genetics 136:781-788.
41. Tebb, G., T. Moll, C. Dowser, and K. Nasmyth. 1993. SWI5 instability may be necessary but is not sufficient for asymmetric HO expression in yeast. Genes Dev. 7:517-528.
42. Thomas, B. J., and R. Rothstein. 1989. Elevated recombination rates in transcriptionally active DNA. Cell 56:619-630.
43. Thomas, J. H. 1993. Thinking about genetic redundancy. Trends Genet 9: 395-399
44. Wang, H., I. Clark, P. R. Nicholson, I. Herskowitz, and D. J. Stillman. 1990. The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs. Mol. Cell. Biol. 10:5927-5936.
45. Wang, H., and D. J. Stillman. 1993. Transcriptional repression in Saccharomyces cerevisiae by a SIN3-lexA fusion protein Mol. Cell. Biol. 13:1805-1814
46. Weintraub, H., T. Genetta, and T. Kadesch. 1994. Tissue-specific gene activation by MyoD: determination of specificity by cis-acting repression elements. Genes Dev. 8:2203-2211.
47. Wright, W. E. 1992 Muscle basic helix-loop-helix proteins and the regulation of myogenesis. Curr. Opin. Gen. Dev. 2:243-248.