Effects of chronic alcohol consumption and aging on dopamine D2 receptors in Fischer 344 rats

Alcoholism: Clinical and Experimental Research

Volumn 20, Issue 1, 1996, Pages 144-151

  Tajuddin, Nuzhath F ^a   Druse, Mary J ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Aging; Alcohol; D2 Receptor; Dopamine

Indexed keywords

ALCOHOL; DOPAMINE 2 RECEPTOR;

AGED; AGING; ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RAT; RECEPTOR BINDING;

AGE FACTORS; ALCOHOLISM; ANIMALS; BRAIN; BRAIN MAPPING; CEREBRAL CORTEX; CORPUS STRIATUM; ETHANOL; FEMALE; LIMBIC SYSTEM; MALE; MESENCEPHALON; RATS; RATS, INBRED F344; RECEPTORS, DOPAMINE D2; SPIPERONE; SUBSTANTIA NIGRA;

EID: 0029938964     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1996.tb01057.x     Document Type: Article

References (19)

1. Liberto JG, Oslin DW, Ruskin PE: Alcoholism in older persons: A review of the literature. Hosp Community Psychiatry 43:975-984, 1992
2. Gupta KL: Alcoholism in the elderly. Uncovering a hidden problem. Postgrad Med 93:203-206, 1993
3. Ryan C, Butters N: Further evidence for a continuum-of-impairment encompassing male alcoholic Korsakoff patients and chronic alcoholic men. Alcoholism 4:190-197, 1980
4. Ryan C, Butters N: Learning and memory impairments in young and old alcoholics: Evidence for the premature-aging hypothesis. Alcoholism 4:288-293, 1980
5. Freund G: Neurotransmitter function in relation to aging and alcoholism, in Hartford JT, Samorajski T (eds): Alcoholism in the Elderly. New York, Raven Press, 1984, p 65
6. De Franco C, Tarbox AR, McLaughlin EJ: Cognitive deficits as a function of years of alcohol abuse. Am J Drug Alcohol Abuse 11:279-293, 1985
7. Markowitsch HJ, Kessler J, Denzler P: Recognition, memory and psychophysiological responses to stimuli with neutral or emotional content: A study of Korsakoff patients and recently detoxified and longterm abstinent alcoholics. J Neurosci 29:1-35, 1986
8. Brower KJ, Mudd S, Blow FC, Young JP, Hill EM: Severity and treatment of alcohol withdrawal in elderly versus younger patients. Alcohol Clin Exp Res 18:196-201, 1994
9. Pfefferbaum A, Lim QO, Zipursky RB, Mathalon DH, Rosenblom MJ, Lane B, Ha CN, Sulivan EV: Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: A quantitative MRI study. Alcoholism 16:1078-1089, 1992
10. Hayakawa K, Kumagai H, Suzuki Y, Furusawa N, Haga T, Hoshi T, Fujiwara Y, Yamaguchi K: MR imaging of chronic alcoholism. Acta Radiol 33:201-206, 1992
11. Meyer JS, Largen JW, Shaw T, Mortel KF, Rogers R: Interactions of normal aging, senile dementia, multi-infarct dementia, and alcoholism in the elderly, in Hartford JT, Samorajski T (eds): Alcoholism in the Elderly: Social and Biomedical Issues. New York, Raven Press, 1984, p 227
12. Morgan DG, Finch CE: Dopaminergic changes in the basal ganglia: A generalized phenomenon of aging in mammals. Ann NY Acad Sci 515:145-160, 1988
13. Severson JA, Wilcox RE: Agonist binding to striatal dopamine receptors in aging: The ternary complex of receptor and guanine nucleotide binding regulatory protein. Ann NY Acad Sci 515:178-189, 1988
14. Palmer AM, DeKosky ST: Monoamine neurons in aging and Alzheimer's disease. J Neural Trans 91:135-159, 1993
15. Severson JA, Marcusson J, Winblad B, Finch CE: Age-correlated loss of dopaminergic binding sites in human basal ganglia. J Neurochem 39:1623-1631, 1982
16. Henry JM, Filburn CR, Joseph JA, Roth GS: Effect of aging on striatal dopamine receptor subtypes in Wistar rats. Neurobiol Aging 7:357-361, 1986
17. Roth GS: Effects of aging on mechanisms of α-adrenergic and dopaminergic action. Fed Proc 45:60-64, 1986
18. Giorgi O, DeMontis G, Porceddu ML, Mele S, Calderini G, Toffano G, G Biggio: Developmental and age-related changes in Dl-dopamine receptors and dopamine content in the rat striatum. Dev Brain Res 35:283-290, 1987
19. Hyttel J: Age related decrease in the density of dopamine D1 and D2 receptors in corpus striatum of rats. Pharmacol Toxicol 61:126-129, 1987