Hormonal regulation of androgen receptor messenger RNA in the medial preoptic area of the male rat

Molecular Brain Research

Volumn 39, Issue 1-2, 1996, Pages 57-67

  Handa, Robert J ^a   Kerr, Janice E ^a   DonCarlos, Lydia L ^a   McGivern, Robert F ^b   Hejna, George ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

Androgen receptor; Bed nucleus of the stria terminalis; Dihydrotestosterone; Estrogen; Estrogen receptor; Medial preoptic area; mRNA

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; ESTROGEN; ESTROGEN RECEPTOR; MESSENGER RNA; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HORMONAL REGULATION; HORMONE RECEPTOR INTERACTION; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MEDIAL PREOPTIC AREA; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; RECEPTOR GENE; STRIA TERMINALIS; TISSUE DISTRIBUTION;

ANIMALIA; TERMINALIS; TRITIUM;

EID: 0029938662     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-328X(95)00353-T     Document Type: Article

References (54)

1. Baum, M.J. (1979) A comparison of the effects of methyltrienolone (R1881) and 5α-dihydrotestosterone on sexual behavior of castrated male rats. Hormone Behav. 13, 165-174.
2. Bloch, G.J., Davidson, J.M. (1968) Effects of adrenalectomy and experience on postcastration sex behaviors in the male rat. Physiol. Behav. 43, 461-465.
3. Brady, L.S., Gold, P.W., Herkenham, M., Lynn, A.B., and Whitfield, H.J. (1992) The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormoen and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications. Brain Res. 572, 117-125.
4. Brown, T.J., Sharma, M., Heisler, L.E., Karsan, N., Walters, M.J., and MacLusky, N.J. (1996) In vitro labeling of gonadal steroid hormone receptors in brain tissue sections. Steroids, in press.
5. Burgess, L.H., and Handa, R.J. (1993) Hormonal regulation of androgen receptor mRNA in the brain and anterior pituitary gland of the male rat. Mol. Brain Res. 19, 31-38.
6. Chang, C., Kokontis, and Liao, S. (1988) Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science 240, 324-326.
7. Christensen, L.W., and Clemens, L.G. (1974) Intrahypothalamic implants of testosterone or estradiol and resumption of masculine sexual behavior in long-term castrated male rats. Endocrinology 95, 324-326.
8. Davidson, J.M. (1966) Characteristics of sex behaviour in male rats following castration. Anim. Behav. 14, 266-272.
9. DonCarlos, L.L., Monroy, E., and Morrell, J.I. (1991) Distribution of estrogen receptor: immunoreactive cells in the forebrain of the female guinea pig. J. Comp. Neurol. 305, 591-612.
10. Evans, R.M. (1988) The steroid and thyroid hormone receptor superfamily. Science 240, 889-895.
11. Feder, H.H., Naftolin, F., and Ryan, K.J. (1974) Male and female sexual responses in male rats given estradiol benzoate and 5α-androstan-17β-ol-3-one propionate. Endocrinology 94, 136-141.
12. Gonzalez-Cadavid, N.F., Vernet, D., Navarro, A.F., Rodriguez, J.A., Swerdloff, R.S., and Rajfer, J. (1993) Up-regulation of the levels of androgen receptor and its mRNa by androgens in smooth-muscle cells from rat penis. Mol. Cell. Endocrinol. 90, 219-229.
13. Hammer, R.P. Jr., Bogic, L., and Handa, R.J. (1993) Estrogenic regulation of proenkephalin mRNA expression in the ventromedial hypothalamus of the adult male rat. Mol. Brain Res. 19, 129-134.
14. Handa, R.J., Reid, D.L., and Resko, J.A. (1986) Androgen receptors in brain and pituitary of female rats: cyclic changes and comparisons with the male. Biol. Reprod. 34, 293-304.
15. Handa, R.J., Roselli, C.E., Horton, L., and Resko, J.A. (1987) The quantitative distribution of cytosolic androgen receptor in microdissected areas of the male rat brain: effects of estrogen treatment. Endocrinology 121, 233-240.
16. Handa, R.J., and Rodriguez, E.W. (1991) A characterization of estrogen's influence on anterior pituitary androgen receptor: effect of bromocriptine treatment. Neuroendocrinology 53, 12-19.
17. Handa, R.J., Nunley, K.A., and Bollnow, M.R. (1993) Induction of c-fos mRNA in the rat brain following exposure to a novel environment. NeuroReport 4, 1079-1082.
18. Heimer, L., and Larsson, K. (1966) Impairment of mating behavior in male rats following lesions in the preoptic-anterior hypothalamic continuum. Brain Res. 3, 248-263.
19. Kerr, J.E., Allore, R.J., Beck, S.G., and Handa, R.J. (1995) Distribution and hormonal regulation of androgen receptor (AR) and AR messenger RNA in the rat hippocampus. Endocrinology 136, 3213-3221.
20. Koike, S., Masaharu, S., and Muramatsu, M. (1987) Molecular cloning and characterization of rat ER cDNA. Nucl. Acids Res. 15, 2499-2513.
21. Larsson, K., Soderstein, P., and Beyer, C. (1973) Sexual behavior in male rats treated with estrogen in combination with dihydrotestosterone. Hormone Behav. 4, 289-299.
22. Larsson, K., and Heimer, L. (1964) Mating behaviour of male rats after lesions in the preoptic area. Nature 202, 413-414.
23. Larsson, K. (1979) Features of the neuroendocrine regulation of masucline sexual behavior. In: Beyer C. (Ed.), Endocrine Control of Sexual Behavior, Raven Press, New York, pp. 77-163.
24. Lauber, A.H., Romano, G.J., Mobbs, C.V., and Pfaff, D.W. (1990) Estradiol regulation of ER messenger ribonucleic acid in rat mediobasal hypothalamus: an in situ hybrization study. J. Neuroendocrinol. 2, 289-299.
25. Lisciotto, C.A., and Morrell, J.I. (1993) Circulating gonadal steroid hormones regulate ER rnRNA in the male rat forebrain. Mol. Brain Res. 20, 79-90.
26. Lowry O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) Protein determinations with the Folin phenol reagent. J. Biol. Chem. 193, 265.
27. Lubahn, D.B., Joseph, D.R., Sar, M., Tan, J., Higgs, HN, Larson, R.E., French, F.S., and Wilson, E.M. (1988) The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate. Mol. Endocrinol. 2, 1265-1275.
28. McGinnis, M.Y., and Dreifuss, R.M. (1989) Evidence for a role of testosterone-androgen receptor interactions in mediating masculine sexual behavior in male rats. Endocrinology 124, 618-626.
29. McLachlan, R.I., Tempel, B.L., Miller, M.A., Bícknell, J.N., Bremner, W.J., and Dorsa, D.M. (1991) Androgen receptor gene expression in the rat central nervous system: evidence for two mRNA transcripts. Mol. Cell. Neurosci. 2, 117-122.
30. Micevych, P.E. (1991) Sexual differentiation of a neuropeptide circuit regulating female reproductive behavior. In: T. Archer and S. Hansen (Eds.), Behavioral Biology: Neuroendocrine Axis. LEA Publ., Hillsdale, NJ, pp. 139-149.
31. Morali, G., Larsson, K., and Beyer, C. (1977) Inhibition of testosterone-induced sexual behavior in the castrated male rat by aromatase blockers. Hormone Behav. 9, 203-213.
32. O'Keefe, J.A., Li, Y., Burgess, L.H., and Handa, R.J. (1995) Alterations in estrogen receptor mRNA levels in the developing rat hippocampus. Mol. Brain Res. 30, 115-124.
33. Paredes, R.G., Highland, L., and Karam, P. (1993) Socio-sexual behavior in male rats after lesions of the medial preoptic area: evidence for reduced sexual motivation. Brain Res. 618, 271-276.
34. Pfaff, D., and Keiner, M. (1973) Atlas of estradiol concentrating cells in the central nervous system of the female rat. J. Comp. Neurol. 151, 121-158.
35. Quarmby, V.E., Yarbrough, W.G., Lubahn, D.B., French, F.S., and Wilson, E.M. (1990) Autologous down-regulation of androgen receptor messenger ribonucleic acid. Mol. Endocrinol. 4, 22-28.
36. Roselli, C.E., and Fasasi, T.A. (1992) Estradiol increases the duration of nuclear androgen receptor occupation in the preoptic area of the male rat treated with dihydrotestosterone. J. Steroid Biochem. Mol. Biol. 42, 161-168.
37. Sachs, B.D., and Meisel, R. (1988) The physiology of male sexual behavior. In: E. Knobil and J. Neill (Eds.), The Physiology of Reproduction, Raven, New York, pp. 1393-1485.
38. 3H]dihydrotestosterone administration. J. Steroid Biochem. 8, 1131-1135.
39. Shugrue, P.J., Bushnell, C.D., and Dorsa, D.M. (1992) Estrogen receptor messenger ribonucleic acid in female rat brain during the estrous cycle: a comparison with ovariectomized females and intact males. Endocrinology 131, 381-388.
40. Shupnik, M.A., Gordon, M.S., and Chin, W.W. (1989) Tissue specific regulaton of rat estrogen receptor mRNAs. Mol. Endocrinol. 3, 660-665.
41. Simerly, R.B., Swanson, L.W., and Gorski, R.A. (1984) Demonstration of a sexual dimorphism in the distribution of serotonin-immunoreactive fibers in the medial preoptic nucleus of the rat. J. Comp. Neurol. 225, 151-166.
42. Simerly, R.B., Chang, C., Muramatsu, M., and Swanson, L.W. (1990) Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J. Comp. Neurol. 294, 76-95.
43. Simerly, R.B., and Young, B.J. (1991) Regulation of estrogen receptor messenger ribonucleic acid in rat hypothalamus by sex steroid hormones. Mol. Endocr. 5, 424-432.
44. Song, C.S., Her, S., Slomczynska, M., Choi, S.J., Jung, M.H., Roy, A.K., and Chatterjee, B. (1993) A distal activation domain is critical in the regulation of the rat androgen receptor gene promoter. Biochem. J. 294, 779-784.
45. Swanson, L.W. (1992) Brain Maps: Structure of the Rat Brain. Elsevier, Amsterdam.
46. Tan, J., Joseph, D.R., Quarmby, V.E., Lubahn, D.B., Sar, M., French, F.S., and Wilson, E.M. (1988) The rat androgen receptor: primary structure, autoregulation of its messenger ribonucleic acid and immunocytochemical localization of the receptor protein. Mol. Endocrinol. 2, 1276-1285.
47. 125I]estrogen autoradiography and non-isotopic in situ hybridization histochemistry. Brain Res. 576, 25-41.
48. Whalen, R.E., Gorzalka, B.B., and DeBold, J.F. (1975) Methodological considerations in the study of anial sexual behavior. In: M. Sandler and G.L. Gessa (Eds.), Sexual Behavior: Pharmacology and Biochemistry, Raven Press, New York, pp. 33-44.
49. Winer, B.J. (1977) Statistical Principles in Experimental Design. McGraw-Hill, New York.
50. Wood, R.I., Brabec, R.K., Swann, J.M., and Newman, S.W. (1992) Androgen and estrogen concentrating neurons in chemosensory pathways of the male syrian hamster brain. Brain Res. 596, 89-98.
51. Wood, R.I., and Newman, S.W. (1993) Intracellular partitioning of androgen receptor immunoreactivity in the brain of the male Syrian hamster: effects of castration and steroid replacement. J. Neurobiol. 24, 925-938.
52. Wood, R.I., and Newman, S.W. (1993) Androgen and estrogen receptors coexist within neurons of the limbic system in the Syrian hamster. Abst. Soc. Neurosci. 19, 820.
53. Yuri, K., and Kawata, M. (1991) The effect of estrogen on the estrogen receptor immunoreactive cells in the rat medial preoptic nucleus. Brain Res. 548, 50-54.
54. Zhou, L., Blaustein, J.D., and De Vries, G.J. (1994) Distribution of androgen receptor: immunoreactivity in vasopressin and oxytocin immunoreactive neurons in the male rat brain. Endocrinology 134, 2622-2627.