Rational design of an animal model for Alzheimer's disease: Introduction of multiple human genomic transgenes to reproduce AD pathology in a rodent

Neurobiology of Aging

Volumn 17, Issue 2, 1996, Pages 173-182

  Loring, Jeanne F ^a,e   Paszty, Chris ^b   Rose, Avidan ^a   McIntosh, Tracy K ^c   Murai, Hisayuki ^c   Pierce, Jean E S ^c   Schramm, Stephen R ^a   Wymore, Kathryn ^a   Lee, Virginia M Y ^c   Trojanowski, John Q ^c   Peterson, Kenneth R ^d  

^a GenPharm International   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e Molecular Dynamics   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Animal model; Antibodies; Apolipoprotein; Brain trauma; Cosmid; FAD mutation; Genomic transgene; Immunohistochemistry; Mouse; Rat; Transgene expression; Transgenic; Yeast artificial chromosome

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E4;

ALZHEIMER DISEASE; ANIMAL MODEL; ARTICLE; GENE MUTATION; HUMAN; IMMUNOHISTOCHEMISTRY; MOLECULAR GENETICS; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0029938431     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(95)02076-4     Document Type: Article

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