Allelic Association but only Weak Evidence for Linkage to the Apolipoprotein E Locus in Late-Onset Swedish Alzheimer Families

American Journal of Medical Genetics - Seminars in Medical Genetics

Volumn 67, Issue 3, 1996, Pages 306-311

  Liu, Li ^a   Forsell, Charlotte ^a   Lilius, Lena ^a   Axelman, Karin ^a   Corder, Elizabeth H ^a   Lannfelt, Lars ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Karoliuska Institute   (Sweden)

Author keywords

Allelic association; Alzheimer's disease; Apolipoprotein E; Chromosome 19; Linkage analysis; Polymorphism

Indexed keywords

APOLIPOPROTEIN E;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME 19; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PEDIGREE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AGE OF ONSET; AGED; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; FEMALE; HUMANS; LINKAGE (GENETICS); MALE; MIDDLE AGED; SWEDEN;

EID: 0029938283     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19960531)67:3<306::AID-AJMG7>3.0.CO;2-K     Document Type: Article

References (19)

1. Babron M-C, Martinez M, Bonaiti-Pellié C, Clerget-Darpoux F (1993): Linkage detection by affected-pedigree-member method: What is really tested? Genet Epidemiol 10:389-394.
2. Bennett C, Crawford F, Osborn A, Diaz P, Hoyne J, Lopez R, Roques P, Duara R, Rossor M, Mullan M (1995): Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's disease but is not causative. Am J Med Genet 60:1-6.
3. Borgaonkar DS, Schmidt LC, Martin SE, Kanzer MD, Edelsohn L, Growdon J, Farrer LA (1993): Linkage of late-onset Alzheimer's disease with apolipoprotein E type 4 on chromosome 19. Lancet 342:625.
4. Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM (1985) Apolipoprotein E association with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 82:1501-1513.
5. Corder E, Basun H, Lannfelt L, Viitanen M, Winblad B (1995): Apolipoprotein Eε4 gene dose. Lancet 346:967-968.
6. Corder EH, Haynes CL, Saunders AM, Locke PA, Conneally PM, Small GW, Roses AD, Haines JL, Pericake-Vance MA (1994): A bayesian extension to the transmission disequilibrium test (TDT) Application to apolipoprotein E and Alzheimer's disease. Am J Hum Genet 55:A205.
7. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericake-Vance MA (1993): Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923.
8. Farrer LA, Myers RH, Cupples LA, St. George-Hyslop PH, Bird TH, Rossor MN, Mullan MJ, Polinsky R, Nee L, Heston L, Van Broeckhoven C, Martin J-J, Crapper-McLachlan D, Growdon JH (1990): Transmission and age-at-onset patterns in familial Alzheimer's disease: Evidence for heterogeneity. Neurology 40:395.
9. Goldin LR, Gershon ES (1993): Linkage of Alzheimer's disease to chromosome 21 and chromosome 19 markers: Effect of age of onset assumptions. Genet Epidemiol 10:449-454.
10. Higuchi R (1989): Efficient DNA extraction for PCR from cells or blood. Amplifications. A forum for PCR users. Cetus Corp 2:1-3.
11. Lannfelt L, Lilius L, Nastase M, Viitanen M, Fratiglioni L, Eggertsen G, Berglund L, Angelin B, Linder J, Winblad B, Basun H (1994): Lack of association between apolipoprotein E allele ε4 and sporadic Alzheimer's disease. Neurosci Lett 168:254-256.
12. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984): Clinical diagnosis of Alzheimer's disease: Report of the NINCDS ARDRA work group under the auspices of Department of Health and Human Services task force on Alzheimer's disease. Neurology 34:939-944.
13. Ott J (1991): "Analysis of Human Genetic Linkage." Baltimore and London: Johns Hopkins University Press, pp 54-80.
14. Saunders AM, Strittmatter WJ, Schmechel D, St George-Hyslop PH, Pericak Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ, Hulette C, Crain B, Goldgaber D, Roses AD (1993): Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43:1467-1472.
15. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance MA, Enghild J, Salvesen GS, Roses AD (1993): Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90:1977-1981.
16. Weeks DE, Lange K (1988): The affected-pedigree-member method of linkage analysis. Am J Hum Genet 42:315-326.
17. Wenham PR, Price WH, Blundell G (1991): Apolipoprotein E genotyping by one-stage PCR. Lancet 337:1158-1159.
18. Wisniewski T, Frangione B (1992): Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosei Lett 135:235-239.
19. Yu C-E, Payami HP, Olson JM, Boehnke M, Wijsman EM, Orr HT, Kukull WA, Goddard KAB, Nemens E, White JA, Aloso ME, Taylor TD, Ball MJ, Kaye J, Morris J, Chui H, Sadovick AD, Martin GM, Larson EB, Heston LL, Bird TD, Schellenberg GD (1994): The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease. Am J Hum Genet 54:631-642.