Preclinical pharmacology of cisatracurium besylate

Current Opinion in Anaesthesiology

Volumn 9, Issue SUPPL. 1, 1996, Pages

  Wastila, William B ^a   Maehr, Robert B ^a   LaMunion, Gary L ^a   Belmont, Matthew R ^a   Savarese, John J ^b  

^a GLAXOSMITHKLINE   (United States)

^b WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATRACURIUM; ATRACURIUM BESILATE; HISTAMINE; NEUROMUSCULAR BLOCKING AGENT;

ANIMAL EXPERIMENT; AUTONOMIC NERVOUS SYSTEM; CARDIOVASCULAR EFFECT; CAT; CHEMICAL STRUCTURE; CONFERENCE PAPER; DOG; DOSE RESPONSE; DRUG POTENCY; HISTAMINE BLOOD LEVEL; NEUROMUSCULAR BLOCKING; NONHUMAN; PRIORITY JOURNAL; RAT; RHESUS MONKEY;

EID: 0029938281     PISSN: 09527907     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001503-199604001-00002     Document Type: Conference Paper

References (19)

1. Miller RD, Rupp SM, Fisher DM, Cronnelly R, Fahey MR, John YJ: Clinical pharmacology of vecuronium and atracurium. Anesthesiology 1984, 61: 444-453.
2. Bevan DR: Atracurium and vecuronium. Can Anaesth Soc J 1985, 32:317-319.
3. Stenlake JB, Waigh RD, Urwin J, Dewar GH, Coker GG: Atracurium: conception and inception. Br J Anaesth 1983, 55 (suppl 1):3S-10S.
4. Belmont MR, Maehr RB, Wastila WB, Savarese JJ: Pharmacodynamics and pharmacokinetics of benzylisoquinolium (curare-like) neuromuscular blocking drugs. Anaesth Clin N Am 1993, 11:251-281.
5. Basta SJ: Modulation of histamine release by neuromuscular blocking drugs. Curr Opin Anaesthesiol 1992, 5:572-576.
6. Maehr RB, Wastila WB: Comparative pharmacology of atracurium and six isomers in cats [abstract]. Anesthesiology 1993, 77:A950.
7. Wastila WB, Maehr RB: The pharmacological profile of 51W89, the R,cis-R′,cis isomer of atracurium in cats [abstract]. Anesthesiology 1993, 77:A946.
8. Belmont M, Beemer G, Bownes P, Wastila W, Savarese JJ: Comparative pharmacology of atracurium and one of its isomers, 51W89, in Rhesus monkeys [abstract]. Anesthesiology 1993, 79:A947.
9. Lien CA, Belmont MR, Abalos A, Eppich L, Quessy S, Abou-Donia M, Savarese JJ: The cardiovascular effects and histamine-releasing properties of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia. Anesthesiology 1995, 82:1131-1138.
10. Belmont MR, Lien CA, Quessy S, Abou-Donia M, Abalos A, Eppich L, Savarese JJ: The clinical neuromuscular pharmacology of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia. Anesthesiology 1995, 82: 1139-1145.
11. Meretoja OA, Taivainen T, Wirtavouri K: Pharmacodynamic effects of 51W89, an isomer of atracurium, in children under halothane anaesthesia. Br J Anaesth 1995, 74:6-11.
12. Lepage JY, Malinovsky JM, Malinge M, Cozian A, Pinand M: 51W89: dose response, neuromuscular blocking profile, and cardiovascular effects [abstract]. Anesthesiology 1993, 79:A945.
13. Savarese JJ: The autonomic margins of safety of metocurine and d-tubocurarine in the cat. Anesthesiology 1979, 50:40-46.
14. Hughes R, Chapple DJ: Effects on non-depolarising neuromuscular blocking agents on peripheral autonomic mechanisms in cats. Br J Anaesth 1976, 48:847-852.
15. Maehr RB, Belmont MR, Wray DL, Savarese JJ, Wastila WB: Autonomic and neuromuscular effects of mivacurium and its Isomers in cats [abstract]. Anesthesiology 1991, 75:A772.
16. Bowman WC, Rodger IW, Houston J, Marshall RJ, McIndewar I: Structure-action relationships among some desacetoxy analogues of pancuronium and vecuronium in the anaesthetised cat. Anesthesiology 1988, 69:57-62.
17. Sutherland GA, Squire IB, Gibb J, Marshall IG: Neuromuscular blocking and autonomic effects of vecuronium and atracurium in the anaesthetised cat. Br J Anaesth 1983, 55:1119-1126.
18. Marshall RJ, Muir AW, Sleigh T, Savage DS: An overview of the pharmacology of rocuronium bromide in experimental animals. J Anaesth 1994, 9 (suppl):9-15.
19. Wastila WB, Maehr RB, Turner GL, Hill DA, Savarese JJ: Comparative pharmacology of cisatracurium (51W89), atracurium, and five isomers in cats. Anesthesiology in press.