Trimethylamine N-oxide: A novel reagent for the promotion of the retro-aldol reaction of R106-1 (LY295337)

Tetrahedron Letters

Volumn 37, Issue 25, 1996, Pages 4301-4304

  Rodriguez, Michael J ^a   Zweifel, Mark J ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; AUREOBASIDIN A; R 106 1; REAGENT; SOLVENT; TRIMETHYLAMINE OXIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; HEATING; HYDROLYSIS; REACTION ANALYSIS; REACTION TIME; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 0029938194     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00830-1     Document Type: Article

References (21)

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8. TNO•2H2O was effective in promoting the retro-aldol reaction on a non-peptide model compound in good yields.
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16. Supplier: Aldrich Chemical Company
17. Reaction monitored by C-18 reverse phase chromatography (30:70 water/acetonitrile, Waters 3.9 X 300 mm μbondapak®2 mL/min, 250 nm).
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21. Compounds 6 and 7 are known compounds previously prepared by Takara Shuzo Company. Haruna, F.; Yamaguchi, H., Nakamura, T.; Uchida, K.; Takesako, K.; Ikai, K.; Yamamoto, J.; Shimanaka, K. Takara Shuzo Co., LTD. EP913004388.