Serum interleukin 2 and soluble interleukin 2 receptor in chronic active hepatitis C: Effect of interferon therapy

Journal of International Medical Research

Volumn 24, Issue 3, 1996, Pages 239-245

  Simsek, H ^a   Kadayifci, A ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Chronic active hepatitis; Interferon; Interleukins

Indexed keywords

INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; RECOMBINANT ALPHA2A INTERFERON;

ADOLESCENT; ADULT; ARTICLE; BLOOD LEVEL; CHRONIC ACTIVE HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS C; HUMAN; LIVER INJURY; MALE; PATHOGENESIS; T LYMPHOCYTE;

EID: 0029937526     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/030006059602400302     Document Type: Article

References (26)

1. Tilg H: The role of cytokines in the pathophysiology of chronic liver diseases. Int J Clin Lab Res 1993; 23: 179-185.
2. Lohr HF, Schlaak JF, Gerken G, et al: Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology. Liver 1994; 14: 161-166.
3. Civeria M, Prieto J, Morte S, et al: Interleukins in chronic active hepatitis B. Relationship with viral markers. J Hepatol 1987; 5: 37-44.
4. Baba M, Fukai K, Hesegawa H, et al: The role of natural killer cells and lymphokine activated killer cells in the pathogenesis of hepatic injury and hepatitis A. Jap J Clin Lab Immunol 1992; 38: 1-14.
5. Robb RJ: Interleukin 2: the molecule and its function. Immunol Today 1984; 5: 203-209.
6. Whittington R, Raulds D. Interleukin 2. Drugs 1993; 46: 446-514.
7. Thornton AJ, Strieter RM, Lindley I, et al: Cytokine-induced gene expression of a neutrophil chemotactic factor/IL-8 in human hepatocytes. J Immunol 1990; 144: 2609-2613.
8. Koch AE, Polverini PJ, Kunkel SL, et al: Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 1992; 258: 1798-1801.
9. Napoli J, Bishop GA, McCaughan GW: Increased intrahepatic messenger RNA expression of interleukins 2, 6 and 8 in human cirrhosis. Gastroenterology 1994; 107: 789-798.
10. Male D, Champion B, Cooke A, et al: Cytokinesis. In: Advance Immunology 2nd Ed. London: Gower Medical, 1991; 11.3-11.5.
11. Lobo-Yeo A, Mieli-Vergani G, Mowat AP, et al: Soluble interleukin 2 receptors in chronic active hepatitis. Gut 1990; 31: 690-693.
12. Vicente-Gutierrez MM, Ruiz AD, Extremera BG, et al: Low serum levels of alpha-interferon, gamma-interferon, and interleukin-2 in alcoholic cirrhosis. Dig Dis Sci 1991; 36: 1209-1212.
13. Miller LC, Kaplan MM. Serum IL-2 and TNF alpha in primary biliary cirrhosis: Decrease by colchicine and relationship to HLA-DR4. Am J Gastroenterol 1992; 87: 465-470.
14. Casafont F, Echevarria, J, Romero FP. IL-2 activity and serum levels of soluble interleukin-2 receptors in chronic active hepatitis B. Dig Dis Sci 1990; 35: 1045.
15. Tilg H, Vogel W, Tratkiewicz J et al: Pilot study of natural human interleukin-2 in patients with chronic hepatitis B. Immunomodulatory and antiviral effects. J Hepatol 1993; 19: 259-267.
16. Knodel RG, Ishak KG, Craig R, et al: Histology activity index for numerical scoring and assessment of asymptomatic chronic active hepatitis liver biopsies. Gastroenterology 1980; 79: 1031.
17. Anastassakos CH, Alexander GJM, Wolstencroft RA et al: Interleukin-1 and interleukin-2 activity in chronic hepatitis B virus infection. Gastroenterology 1988; 94: 999-1005.
18. Alberti A, Chemello L, Fattovich G et al: Serum levels of interleukin-2 receptors in acute and chronic viral hepatitis. Dig Dis Sci 1989; 34: 1559-1563.
19. Lai KN, Leung JCK, Tam JS et al: T lymphocyte activation in chronic hepatitis B infection: Interleukin-2 release and its receptor expression. Am J Gastroenterol 1988; 84: 1532-1537.
20. Fujioka H: Studies on correlation between mRNA expression of cytokines in the liver and liver biopsy findings in chronic hepatitis C. Acta Hepatol Jpn 1993; 34: 940-949.
21. Simsek H, Özyilkan E, Telatar H: Interferon treatment of chronic active hepatitis C in patients with and without chronic renal failure (Abstract). Gastroenterology 1994; 106: A987.
22. Simsek H: Interferon-alpha treatment of hemodialysis patients with chronic viral hepatitis and its impact on kidney transplantation. Nephrol Dialy Transplant 1996; (in press).
23. Simsek H, Savas C, Tatar G, et al: Treatment of chronic active hepatitis C infection with interferon alpha 2a in Turkish population. J Int Med Res 1996; 24: 132-137.
24. Dolar EM, Baysal C, Dalva K, et al: Serum levels of cytokines in chronic viral liver disease. Eur J Gastroenterol Hepatol 1993; 5: 947-950.
25. Caruso C, Candero G, Cigna D et al: Serum levels of soluble IL-2R, CD4 and CD8 in chronic active HCV positive hepatitis. Mediators of Inflammation 1994; 3: 185-187.
26. Rubin LA, Kurman CC, Fritz ME, et al: Identification and characterization of a released form of the interleukin-2 receptor. In: Leukocytes and Host Defense (Oppenheim JJ, Jacops DM, eds). New York: Alan R Liss, 1986.