Neurotoxic convulsions induced by theophylline and its metabolites in mice

Biological and Pharmaceutical Bulletin

Volumn 19, Issue 6, 1996, Pages 869-872

  Yamamoto, Koujirou ^a   Toyama, Etsuko ^a   Kawakami, Junichi ^a   Sawada, Yasufumi ^b   Iga, Tatsuji ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

metabolite; mouse; neurotoxicity; theophylline

Indexed keywords

THEOPHYLLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DETERMINATION; DRUG MEGADOSE; DRUG POTENCY; INTRACEREBRAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NEUROTOXICITY; NONHUMAN; RISK FACTOR;

EID: 0029937292     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.19.869     Document Type: Article

References (13)

1. Hendeles L., Weinherger M., Johnson G., Clin. Pharmacokin., 3, 294-312 (1978).
2. Yarnell P. R., Chu N.-S., Neurology, 25, 819-822 (1973).
3. Zwillich C. W., Sutton F. D., Neff T. A., Cohn W. M., Matthay R. A., Weinberger M. M., Ann. Intern. Med., 82, 784-787 (1975).
4. Jenne J. W., Nagasawa H. T., Thompson R. D., Clin. Pharmacol. Ther., 19, 375-381 (1976).
5. Bauer L. A., Buer S. P., Blouin R. A., J. Clin. Pharmacol., 22, 65-68 (1981).
6. Ramzan I. M., Levy G., J. Pharmacol. Exp. Ther., 236, 708-713 (1986).
7. Leakey T. E. B., Elias-Jones A. C., Coates P. E., Smith K. J., Clin. Pharmacokin., 21, 400-408 (1991).
8. Shimokawa M., Yamamoto K., Kawakami J., Sawada Y., Iga T., Toxicol. Appl. Pharmacol., 136, 317-323 (1996).
9. Shimokawa M, Yamamoto, K., Kawakami, J., Sawada Y., Iga T., Pharm. Res., 11, 1520-1524 (1994).
10. Nakada Y., Yamamoto K., Kawakami J., Sawada Y., Iga T., Pharm. Res., 12, 1953-1957 (1995).
11. Danhof M., Hisaoka M., Levy G., J. Pharmacol. Exp. Ther., 230, 627-631 (1984).
12. Ramzan I.M., Levy G., J. Pharmacol. Exp. Ther., 240, 584-588 (1986).
13. Danhof M., Levy G., J. Pharmacol. Exp. Ther., 229, 44-50 (1983).