The γ1 heavy chain gene includes all of the cis-acting elements necessary for expression of properly regulated germ-line transcripts

Journal of Immunology

Volumn 157, Issue 1, 1996, Pages 176-182

  Elenich, Laura A ^a,b   Ford, Charleen S ^a   Dunnick, Wesley A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; DNA FLANKING REGION; DNA RECOMBINATION; GENE EXPRESSION; GENE INSERTION; GENE LOCUS; GENETIC TRANSCRIPTION; GERM LINE; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION; TRANSCRIPTION REGULATION; TRANSGENE;

ANIMALS; BASE SEQUENCE; GENE DELETION; GENE EXPRESSION REGULATION; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN GAMMA-CHAINS; IMMUNOGLOBULIN SWITCH REGION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; REGULATORY SEQUENCES, NUCLEIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; TRANSGENES;

EID: 0029937212     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Lutzker, S., and F. W. Alt. 1988. Immunoglobulin heavy chain class switching. In Mobile DNA. D. E. Berg and M. M. Howe, eds. ASM Press, Washington, D. C., p. 691.
2. Coffman, R. L., D. A. Lebman, and P. Rothman. 1993. The mechanism and regulation of immunoglobulin isotype switching. Adv. Immunol. 54:229.
3. Bergstedt-Lindqvist, S., P. Sideras, H. R. MacDonald, and E. Severinson. 1984. Regulation of Ig class secretion by soluble products of certain T-cell lines. Immunol. Rev. 78.25.
4. Isakson, P. C., E. Pure, E. S. Vitetta, and P. H. Krammer. 1982. T cell-derived B cell differentiation factors: effect on the isotype switch of murine B cells. J Exp. Med. 155:734.
5. Layton, J. E., E. S. Vitetta, J. W. Uhr, and P. H. Krammer. 1984. Clonal analysis of B cells induced to secrete IgG by T cell-derived lymphokines. J. Exp. Med. 160:1850.
6. Chu, C. C., E. E. Max, and W. E. Paul. 1993. DNA rearrangement can account for in vitro switching to IgGI. J. Exp. Med. 178:1381.
7. Stavnezer-Nordgren, J., and S. Sirlin. 1986. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. EMBO J. 5:95.
8. H replacement by a LINE-1 sequence and directed class switching. EMBO J. 5:3259.
9. Stavnezer, J., G. Radcliffe, Y.-C. Lin, J. Nietupski, L. Berggren, R. Sitia, and E. Severinson. 1988. Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes. Proc. Natl. Acad. Sci. USA 85:7704.
10. Esser, C., and A. Radbruch. 1989. Rapid induction of transcription of unrearranged Sγ1 switch regions in activated murine B cells by interleukin 4. EMBO J. 8:483.
11. Berton, M. T., J. W. Uhr, and E. S. Vitetta. 1989. Synthesis of germ-line γ1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon γ. Proc. Natl. Acad. Sci. USA 86:2829.
12. Schmitz, J., and A. Radbruch. 1989. An interleukin 4-induced DNase I hypersensitive site indicates opening of the γ1 switch region prior to switch recombination. Int. Immunol. 1:570.
13. Berton, M. T., and E. S. Vitetta. 1990. Interleukin 4 induces changes in the chromatin structure of the γ1 switch region in resting B cells before switch recombination. J. Exp. Med. 172:375.
14. Giannini, S. L., M. Singh, C.-F. Calvo, G. F. Ding, and B. K. Birshtein. 1993. DNA regions flanking the mouse Ig 3′ α enhancer are differentially methylated and DNase I hypersensitive during B cell differentiation. J. Immunol. 150:1772.
15. Madisen, L., and M. Groudine. 1994. Identification of a locus control region (LCR) in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev. 8:2212.
16. Burger, C., and A. Radbruch. 1990. Protective methylation of immunoglobulin and T cell receptor (TCR) gene loci prior to induction of class switch and TCR recombination. Eur. J. Immunol. 20:2285.
17. Albrecht, B., S. Peiritsch, and M. Woisetschlager. 1994. A bifunctional control element in the human IgE germline promoter involved in repression and IL-4 activation. Int. Immunol. 8:1143.
18. Delphin, S., and J. Stavnezer. 1995. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain ∈ promoter: regulation by NF-IL4, a C/EBP family member, and NF-κB p50. J. Exp. Med. 181:181.
19. Ichiki, T., W. Takahashi, and T. Watanabe. 1992. The effect of cytokines and mitogens on the induction of C∈ germline transcripts in a human Burkitt lymphoma B cell line. Int. Immunol. 4:747.
20. Illges, H., and A. Radbruch. 1992. DNA binding sites 5′ of the IgG1 switch region comprising IL4 inducibility and B cell specificity. Mol. Immunol. 29:1265.
21. Kotanides, H., and N. C. Reich. 1993. Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science 262:1265.
22. Lin, Y.-C., and J. Stavnezer. 1992. Regulation of transcription of the germ-line Igα constant region gene by an ATF element and by novel transforming growth factor-β1-responsive elements. J. Immunol. 149:2914.
23. Lundgren, M., C. Larsson, A. Femino, M. Xu, J. Stavnezer, and E. Severinson. 1994. Activation of the Ig germ-line γ1 promoter: involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site. J. Immunol. 153:2983.
24. Rothman, P., S. C. Li, B. Gorham, L. Glimcher, F. W. Alt, and M. Boothby. 1991, Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line ∈ transcripts. Mol. Cell. Biol. 11:5551.
25. Kim, J., R. Reeves, P. Rothman, and M. Boothby. 1995. The non-histone chromosomal protein HMG-I(Y) contributes to repression of the immunoglobulin heavy chain germ-line ∈ RNA promoter. Eur. J. Immunol. 25:798.
26. Berton, M. T., and L. E. Linehan. 1995. IL-4 activates a latent DNA-binding factor that binds a shared IFN-γ and IL-4 response element present in the germ-line γ1 Ig promoter. J. Immunol. 154:4513.
27. Williams, M., and N. Maizels. 1991. LR1, a lipopolysaccharide-responsive factor with binding sites in the immunoglobulin switch regions and heavy-chain enhancer. Genes Dev. 5:2353.
28. Warren, W. D., and M. T. Berton. 1995. Induction of germ-line γ1 and ∈ Ig gene expression in murine B cells: IL-4 and CD40 ligand-CD40 interaction provide distinct but synergistic signals. J. Immunol. 155:5637.
29. Lars, N., and S. Paschalis. 1993. The human Iα1 and Iα2 germline promoter elements: proximal positive and distal negative elements may regulate the tissue specific expression of Cα1 and Cα2 germline transcripts. Int. Immunol. 5:271.
30. Xu, M., and J. Stavnezer. 1992. Regulation of transcription of immunoglobulin germ-line γ1 RNA: analysis of the promoter/enhancer. EMBO J. 11:145.
31. Jung, S., K. Rajewsky, and A. Radbruch. 1993. Shutdown of class switch recombination by deletion of a switch region control element. Science 259:984.
32. Xu, L., B. Gorham, S. C. Li, A. Bottaro, F. W. Alt, and P. Rothman. 1993. Replacement of germ-line ∈ promoter by gene targeting alters control of immunoglobulin heavy chain class switching. Proc. Natl. Acad. Sci. USA 90:3705.
33. Zhang, J., A. Bottaro, S. Li, V. Stewart, and F. W. Alt. 1993. A selective defect in IgG2b switching as a result of targeted mutation of the Iγ2b promoter and exon. EMBO J. 12:3529.
34. Bottaro, A., R. Lansford, L. Xu, J. Zhang, P. Rothman, and F. W. Alt. 1994. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J. 13:665.
35. Lorenz, M., S. Jung, and A. Radbruch. 1995. Switch transcripts in immunoglobulin class switching. Science 267:1825.
36. Gu, H., Y.-R. Zou, and K. Rajewsky. 1993. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through CreloxP-mediated gene targeting. Cell 73:1155.
37. Cogne, M., R. Lansford, A. Bottaro, J. Zhang, J. German, F. Young, H.-L. Cheng, and F. W. Alt. 1994. A class switch control region at the 3′ end of the immunoglobulin heavy chain locus. Cell 77:737.
38. Berton, M. T., and E. S. Vitetta. 1992. IL-4-induced expression of germline γ1 transcripts in B cells following cognate interactions with T helper cells. Int. Immunol. 4:387.
39. Schultz, C. L., P. Rothman, R. Kuhn, M. Kehry, W. Muller, K. Rajewsky, F. Alt, and R. L. Coffman. 1992. T helper cell membranes promote IL-4-independent expression of germ-line Cγ1 transcripts in B cells. J. Immunol. 149:60.
40. H ribonucleic acid expression in murine B cells. J. Immunol. 154:1223.
41. H transcription, and Ig class switching. J. Immunol. 156:183.
42. Mowalt, M. R., and W. A. Dunnick. 1986. DNA sequence of the murine γ1 switch segment reveals novel structural elements. J. Immunol. 136:2674.
43. Hogan, B., F. Constantini, and E. Lacy. 1986. Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Press, New York.
44. Coffman, R. L., and J. Carty. 1986. A T cell activity that enhances polyclonal IgE production and its inhibition by Interferon-γ. J. Immunol. 136:949.
45. Wysocki, L. J., and V. L. Sato. 1978. "Panning" for lymphocytes: a method for cell selection. Proc. Natl. Acad. Sci. USA 75:2844.
46. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
47. Schultz, C. L., L. A. Elenich, and W. Dunnick. 1991. Nuclear protein binding to octamer motifs in the immunoglobulin γ1 switch region. Int. Immunol. 3:109.
48. Xu, M., and J. Stavnezer. 1990. Structure of germline immunoglobulin heavychain γ1 transcripts in interleukin 4-treated mouse spleen cells. Dev. Immunol. 1:11.
49. Goodman, D. J., C. Gaff, and S. Gerondakis. 1993. The IL-4 induced increase in the frequency of resting murine splenic B cells expressing germline Ig heavy chain γ1 transcripts correlates with subsequent switching to IgG1. Int. Immunol. 5:199.
50. Kuppuswamy, M. N., J. W. Hoffmann, C. K. Kasper, S. G. Spitzer, S. L. Groce, and S. P. Bajaj. 1991. Single nucleotide primer extension to detect genetic diseases: experimental application to hemophilia B factor IX and cystic fibrosis genes. Proc. Natl. Acad. Sci. USA 88:1143.
51. Singer-Sam, J., J. M. LeBon, A. Dai, and A. D. Riggs. 1992. A sensitive, quantitative assay for measurement of allele-specific transcripts differing by a single nucleotide. PCR Methods Applications 1:160.
52. Clark, J. M. 1988. Novel non-templated nucleotide addition reactions catalyzed by procaryotic and eucaryotic DNA polymerases. Nucleic Acids Res. 16:9677.
53. Durdik, J., R. M. Gerstein, S. Rath, P. F. Robbins, A. Nisonoff, and E. Selsing. 1989. Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice. Proc. Natl. Acad. Sci. USA 86:2346.
54. Gram, H., G. Zenke, S. Geisse, B. Kleuser, and K. Burki. 1992. High-level expression of a human immunoglobulin γ1 transgene depends on switch region sequences. Eur. J. Immunol. 22:1185.
55. Aronow, B. J., R. N. Silbiger, M. R. Dusing, J. L. Stock, K. L. Yager, S. S. Potter, J. J. Hutton, and D. A. Wiginton. 1992. Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression. Mol. Cell. Biol. 12:4170.
56. Greaves, D. R., F. D. Wilson, G. Lang, and D. Kioussis. 1989. Human CD2 3′-flanking sequences confer high-level, T cell-specific, position independent gene expression in transgenic mice. Cell 56:979.
57. Grosveld, F., G. B. van Assendelft, D. R. Greaves, and G. Kollias. 1987. Position-independent, high-level expression of the human β-globin gene in transgenic mice. Cell 51:975.
58. Townes, T. M., and R. R. Behringer. 1990. Human globin locus activation region LAR: role in temporal control. Trends Genet. 6:219.
59. Dariavach, P., G. T. Williams, K. Campbell, S. Pettersson, and M. S. Neuberger. 1991. The mouse IgH 3′ enhancer. Eur. J. Immunol. 21:1499.
60. Lieberson, R., S. L. Gianni, B. K. Birshtein, and L. Eckhardt. 1991. An enhancer at the 3′ end of the mouse immunoglobulin heavy chain locus. Nucleic Acids Res. 19:933.