Kinetics of serum antiplatelet antibodies in experimental acute canine ehrlichiosis

Veterinary Immunology and Immunopathology

Volumn 51, Issue 1-2, 1996, Pages 13-20

  Harrus, Shimon ^a   Waner, Trevor ^b   Weiss, Douglas J ^c   Keysary, Avi ^d   Bark, Hylton ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b Life Science Research Israel   (Israel)

^c UNIVERSITY OF MINNESOTA   (United States)

^d ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

antiplatelet antibodies; E. canis; kinetics; platelets; thrombocytopenia

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G; THROMBOCYTE ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; DOG; EHRLICHIA CANIS; EHRLICHIOSIS; FLOW CYTOMETRY; KINETICS; MALE; NONHUMAN; THROMBOCYTOPENIA;

EID: 0029936960     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-2427(95)05516-9     Document Type: Article

References (20)

1. Abeygunawardena, I., Kakoma, I. and Smith, R.D., 1990. Pathophysiology of canine ehrlichiosis. In: J.C. Williams and I. Kakoma (Editors), Ehrlichiosis. A Vector-Borne Disease of Animals and Humans. Kluwer Academic Press, Dordrecht, pp. 78-92.
2. Avrameas, S., 1991. Natural autoantibodies: from 'horror autotoxicus' to 'gnothi seauton'. Immunol. Today, 12: 154-159.
3. Beardsley, D.S., 1989. Platelet autoantigens. In: T.J. Kunicki and J.N. George (Editors), Platelet Immunobiology. Molecular and Clinical Aspects. J.B. Lippincott Co., Philadelphia, pp. 305-336.
4. Breitchwerdt, E.B., 1995. The Rickettsioses. In: S.J. Ettinger and E.C. Feldman (Editors), Textbook of Veterinary Internal Medicine. Diseases of the Dog and Cat. W.B. Saunders Co., Philadelphia, pp. 376-383.
5. Burghen, G.A., Beisel, W.R., Walker, J.S., Nims, R.M., Huxsoll, D.L. and Hildebrandt, P.K., 1971. Development of hypergammaglobulinemia in tropical canine pancytopenia. Am. J. Vet. Res., 32: 749-756.
6. Campbell, K.L., George, J.W. and Greene, C.E., 1984. Application of the enzyme-linked immunosorbent assay for the detection of platelet antibodies in dogs. Am. J. Vet. Res., 45: 2561-2564.
7. Donatien, A. and Lestoquard, F., 1935. Existence en Algerie d'une Rickettsia du chein. Bull. Soc. Pathol. Exot. Filiates, 28: 418-419.
8. Feldman, B.F., Thompson, K.J. and Jain, N.C., 1988. Quantitative platelet disorder. Vet. Clin. N. Am., 18: 35-49.
9. George, J.N., 1990. Platelet immunoglobulin G: its significance for the evaluation of thrombocytopenia and for understanding the origin of alpha-granule proteins. Blood, 76: 859-870.
10. Kristensen, A.T., Weiss, D.J., Klausner, J.S., Laber, J. and Christie, D.J., 1994a. Comparison of microscopic and flow cytometric detection of platelet antibody in dogs suspected of immune-mediated thrombocytopenia. Am. J. Vet. Res., 55: 1111-1114.
11. Kristensen, A.T., Weiss, D.J., Klausner, J.S., Laber, J. and Christie, D.J., 1994b. Detection of antiplatelet antibody with a platelet immunofluorescence assay. J. Vet. Int. Med., 8: 36-39.
12. Lewis, D.C., Meyers, K.M., Callan, B., Bucheler J. and Giger U., 1995. Detection of platelet-bound and serum platelet-bindable antibodies for diagnosis of idiopathic thrombocytopenic purpura in dogs. Am. J. Vet. Res., 206: 47-52.
13. Ristic, M. and Holland, C.J., 1993. Canine ehrlichiosis. In: Z. Woldehiwet and M. Ristic (Editors), Rickettsial and Chlamydial Diseases of Domestic Animals. Pergamon Press, Oxford, pp. 169-186.
14. Ristic, M., Huxsoll, D.L., Weisiger, R.M., Hildebrandt. P.K. and Nyindo, M.B.A., 1972. Serological diagnosis of tropical canine pancytopenia by indirect immunofluorescence. Infect. Immunol., 6: 226-231.
15. Smith, R.D., Hooks, J.E., Huxsoll, D.L. and Ristic, M., 1974. Canine ehrlichiosis (tropical canine pancytopenia): survival of phosphorus-32-labelled blood platelets in normal and infected dogs. Am. J. Vet. Res., 35: 269-273.
16. Smith, R.D., Ristic, M., Huxsoll, D.L. and Baylor, R.A., 1975. Platelet kinetics in canine ehrlichiosis: evidence for increased platelet destruction as the cause of thrombocytopenia. Infect. Immunol., 11: 1216-1221.
17. Ternynck, T., Bleux, C., Gregoire, J., Avrameas, S. and Kanellopoulos-Langevin, C., 1990. Comparison between antoantibodies arising during Trypanosoma cruzi infection in mice and natural antoantibodies. J. Immunol., 144: 1504-1511.
18. Waner, T., Harrus, S., Weiss, D.J., Bark, H. and Keysary, A., 1995. Demonstration of serum antiplatelet antibodies in experimental acute canine ehrlichiosis. Vet. Immunol. Immunopathol., 48: 177-182.
19. Weisiger, R.M., Ristic, M. and Huxsoll, D.L., 1975. Kinetics of antibody response to Ehrlichia canis assayed by the indirect fluorescent antibody method. Am. J. Vet. Res., 36: 689-694.
20. Woody, B.J. and Hoskins, J.D., 1991. Ehrlichial diseases in dogs. Vet. Clin. N. Am., 21: 75-98.