Preparation of superoxide dismutase entrapped in ceramide-containing liposomes for oral administration

International Journal of Pharmaceutics

Volumn 132, Issue 1-2, 1996, Pages 263-266

  Regnault, C ^a,d   Benoist, C ^a   Fessi, H ^a   Roch Arveiller, M ^b   Postaire, E ^c   Hazebroucq, G ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b Hôpital Cochin ^*  (France)

^c Pharm Centrale des Hôpitaux   (France)

^d Sch Pharm 5 R J B C   (France)

Author keywords

Ceramides; Distearoylphosphatidylcholine; Liposomes; Multilamellar vesicles; Superoxide dismutase

Indexed keywords

CERAMIDE; COPPER ZINC SUPEROXIDE DISMUTASE; DIPALMITOYLPHOSPHATIDYLCHOLINE; DISTEAROYLPHOSPHATIDYLCHOLINE; LIPOSOME; SUPEROXIDE DISMUTASE;

ARTICLE; ELECTRON MICROSCOPY; ENCAPSULATION; PARTICLE SIZE; PRIORITY JOURNAL;

EID: 0029936913     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04235-0     Document Type: Article

References (7)

1. Freeman, B.A., Young, S.L. and Crapo, J.D., Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. J. Biol. Chem., 258 (1983) 12534-12542.
2. McCord, J.M. and Fridovich, I., Superoxide dismutase: an enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem., 244 (1969) 6049-6055.
3. Michelson, A.M., Free radicals and disease: treatment and clinical application with superoxide dismutase. In: Free radicals, aging, and degenerative diseases, Eds. Johnson, J.E., Walford, R., Harman, D., and Miquel, J., New York. 1986, pp. 263-291.
4. Nagata, M., Yotsuyanagi, T. and Ikeda, K., A two-step model of disintegration kinetics of liposomes in bile salts. Chem. Pharm. Bull., 36 (1988) 1508-1513.
5. Regnault, C., Roch-Arveiller, M., Tissot, M., Sarfati, G., Postaire, E. and Hazebroucq, G., Effect of encapsulation on Superoxide Dismutase anti-inflammatory properties after oral administration. Clin. Chim. Acta, 240 (1995) 117-127.
6. Regnault, C., Soursac, M., Roch-Arveiller, M., Postaire, E. and Hazebroucq, G., Pharmacokinetics of Superoxide Dismutase in rat after oral administration. Biopharm. Drug Dispos., in press (1996).
7. Vatier, J., Harman, A., Castela, N., Droy-lefaix, M.T. and Farinotti, R., Interactions of cimetidine and ranitidine with aluminium-containing antacids and a clay-containing gastric-protective drug in an "artificial stomach-duodenum" model. J. Pharm. Sci., 83 (1994) 962-966.