Use of serotonin (5-HT) and opiate-based drugs in the pharmacotherapy of alcohol dependence: An overview of the preclinical data

Alcohol and Alcoholism

Volumn 31, Issue SUPPL. 1, 1996, Pages 27-32

  Lê, Anh Dzung ^a   Tomkins, Denise M ^a   Sellers, Edward M ^a  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; BEMESETRON; BRAIN RECEPTOR; DOPAMINE; ENDORPHIN; NALOXONE; NALTREXONE; NEUROTRANSMITTER; ONDANSETRON; OPIATE ANTAGONIST; RITANSERIN; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN UPTAKE INHIBITOR; TROPISETRON; ZACOPRIDE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; NARCOTIC AGENT; SEROTONIN RECEPTOR;

ALCOHOL CONSUMPTION; ALCOHOLISM; CONFERENCE PAPER; DRINKING BEHAVIOR; DRUG EFFICACY; HUMAN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR BLOCKING; ANIMAL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; HUMANS; NARCOTICS; NEUROTRANSMITTER AGENTS; RECEPTORS, SEROTONIN; SEROTONIN;

EID: 0029936773     PISSN: 07350414     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.alcalc.a008215     Document Type: Conference Paper

References (51)

1. Beczkowska, I. W. and Bodnar, R. J. (1991) Naloxone and serotonin receptor subtype antagonists: interactive effects upon deprivation-induced intake. Pharmacology, Biochemistry and Behavior 38, 605-610.
2. Bendotti, C. and Samanin, R. (1986) 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) elicits eating in free feeding rats by acting on central serotonin neurons. European Journal of Pharmacology 121, 147-150.
3. Benjamin, D., Grant, E. R. and Pohorecky, L. A. (1993) Naltrexone reverses ethanol-induced dopamine release in the nucleus accumbens in awake, freely moving rats. Brain Research 621, 137-140.
4. Buczek, Y., Tomkins, D. M., Higgins, G. A. and Sellers, E. M. (1994) Dissociation of serotonergic regulation of anxiety and ethanol self-administration: a study with mCPP. Behavioural Pharmacology 5, 470-484.
5. Di Chiara, G. and Imperato, A. (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proceedings of the National Academy of Sciences of the United States of America 85, 5274-5278.
6. 3 receptor antagonist, suppresses voluntary ethanol consumption in alcohol-preferring rats. Alcohol and Alcoholism 26, 107-110.
7. Froehlich, J. C., Zweifel, M., Harts, J., Lumeng, L. and Li, T.-K. (1991) Importance of delta opioid receptors in maintaining high alcohol drinking. Psychopharmacology 103, 467-472.
8. Higgins, G. A., Tomkins, D. M., Fletcher, P. J. and Sellers, E. M. (1992) Effect of drugs influencing 5-HT function on ethanol drinking and feeding behaviour in rats: studies using a drinkometer system. Neuroscience and Biobehavioral Reviews 16, 535-552.
9. 1A receptor agonist 8-OH DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis. Life Sciences 48, 1779-1786.
10. 3 antagonist ICS 205-930. Alcohol 10, 191-196.
11. Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R. and Humphrey, P. P. A. (1994) VII International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacological Reviews 46, 157-203.
12. Hunt, W. A. (1993) Neuroscience research: how has it contributed to our understanding of alcohol abuse and alcoholism? A review. Alcoholism: Clinical and Experimental Research 17, 1055-1065.
13. Hutson, P. H., Dourish, C. T. and Curzon, G. (1986) Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors. European Journal of Pharmacology 129, 347-352.
14. Hyytiä, P. (1993) Involvement of μ-opioid receptors in alcohol drinking by alcohol-preferring AA rats. Pharmacology, Biochemistry and Behavior 45, 697-701.
15. Hyytiä, P. and Sinclair, J. D. (1993) Responding for oral ethanol after naloxone treatment by alcohol-preferring AA rats. Alcoholism: Clinical and Experimental Research 17, 631-636.
16. 3 receptors control dopamine release in the nucleus accumbens of freely moving rats. Neuroscience Letters 101, 214-217.
17. 3 receptor blockade: a preliminary study in healthy male volunteers. Psychopharmacology 112, 142-144.
18. Khachaturian, H., Lewis, M. E., Schäfer, M. K.-H. and Watson, S. J. (1985) Anatomy of the CNS opioid systems. Trends in Neurosciences 8, 111-119.
19. 3 receptor antagonist, reduces voluntary ethanol consumption in rats. Pharmacology, Biochemistry and Behavior 41, 847-850.
20. Kostowski, W. and Dyr, W. (1992) Effects of 5-HT-1A receptor agonists on ethanol preference in the rat. Alcohol 9, 283-286.
21. 3 receptor antagonist ICS 205-930 to inhibit alcohol preference and withdrawal seizures in rats. Alcohol 10, 369-373.
22. 3 receptor antagonist in the regulation of alcohol intake. Alcohol and Alcoholism 29 (Suppl. 2), in press.
23. Lê, A. D., Poulos, C. X., Quan, B. and Chow, S. (1993) The effects of selective blockade of delta and mu opiate receptors on ethanol consumption by C57BL/6 mice in a restricted access paradigm. Brain Research 630, 330-332.
24. Linseman, M. A. (1989) Central vs. peripheral mediation of opioid effects on alcohol consumption in free-feeding rats. Pharmacology, Biochemistry and Behavior 33, 407-413.
25. Litten, R. Z. and Allen, J. P. (1991) Pharmacotherapies for alcoholism: promising agents and clinical issues. Alcoholism: Clinical and Experimental Research 15, 620-633.
26. Martin, G. R. and Humphrey, P. P. A. (1994) Receptors for 5-hydroxytryptamine: current perspectives on classification and nomenclature. Neuropharmacology 33, 261-273.
27. Mason, B. J., Ritvo, E. C., Morgan, R. O., Salvato, F. R., Goldberg, G., Welch, B. and Mantero-Atienza, E. (1994) A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCl for alcohol dependence. Alcoholism: Clinical and Experimental Research 18, 1162-1167.
28. McBride, W. J., Murphy, J. M., Lumeng, L. and Li, T.-K. (1990) Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats. Alcohol 7, 199-205.
29. 1A receptors in the CNS of alcohol-preferring and -nonpreferring rats. Pharmacology, Biochemistry and Behavior 49, 7-12.
30. Meert, T. F. (1993) Effects of various serotonergic agents on alcohol intake and alcohol preference in Wistar rats selected at two different levels of alcohol preference. Alcohol and Alcoholism 28, 157-170.
31. Meert, T. F., Awouters, F., Niemegeers, C. J. E., Schellekens, K. H. L. and Janssen, P. A. J. (1991) Ritanserin reduces abuse of alcohol, cocaine, and fentanyl in rats. Pharmacopsychiatry 24, 159-163.
32. 2 receptor antagonist, ritanserin, to alter preference for alcohol in drinking rats. Pharmacology, Biochemistry and Behavior 45, 233-237.
33. Naranjo, C. A. and Bremner, K. E. (1992) Evaluation of the effects of serotonin uptake inhibitors in alcoholics: a review. In Novel Pharmacological Interventions for Alcoholism, Naranjo, C. A., Sellers, E. M. eds, pp. 105-117. Springer Verlag, New York.
34. Naranjo, C. A. and Bremner, K. E. (1994) Serotonin-altering medications and desire, consumption and effects of alcohol-treatment implications. In Toward A Molecular Basis of Alcohol Use and Abuse, Jansson, B., Jörnvall, H., Rydberg, U., Terenius, L. and Vallee, B. L. eds, pp. 209-219. Birkhäuser Verlag, Basel, Switzerland.
35. O'Malley, S. S., Jaffe, A. J., Chang, G., Schottenfeld, R. S., Meyer, R. E. and Rounsaville, B. (1992) Naltrexone and coping skills therapy for alcohol dependence. Archives of General Psychiatry 49, 881-887.
36. Panocka, I., Ciccocioppo, R., Polidori, C. and Massi, M. (1993) The nucleus accumbens is a site of action for the inhibitory effect of ritanserin on ethanol intake in rats. Pharmacology, Biochemistry and Behavior 46, 857-862.
37. Portoghese, P. S., Sultana, M. and Takemori, A. E. (1990) Design of peptidomimetic δ opioid receptor antagonists using the message-address concept. Journal of Medicinal Chemistry 33, 1714-1720.
38. Reid, L. D. and Hubbell, C. L. (1990) Opioids modulate rats' propensities to take alcoholic beverages. In Novel Pharmacological Interventions for Alcoholism, Naranjo, C. A. and Sellers, E. M. eds, pp. 121-134. Springer-Verlag, New York.
39. Reid, L. D. and Hunter, G. A. (1984) Morphine and naloxone modulate intake of ethanol. Alcohol 1, 33-37.
40. 1A receptors. Psychopharmacology 112, 100-110.
41. Sellers, E. M., Higgins, G. A. and Sobell, M. B. (1992) 5-HT and alcohol abuse. Trends in Pharmacological Sciences 13, 68-75.
42. 3 antagonist ondansetron in alcohol abuse and dependence. Alcoholism: Clinical and Experimental Research 18, 879-885.
43. 1A selective drugs on the 5-HT behavioral syndrome. Pharmacology, Biochemistry and Behavior 24, 1513-1519.
44. 1A receptor agonists. Neuropharmacology 32, 977-985.
45. Svensson, L., Fahlke, C., Hård, E. and Engel, J. A. (1993) Involvement of the serotonergic system in ethanol intake in the rat. Alcohol 10, 219-224.
46. 1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) increase ethanol intake. Psychopharmacohgy 115, 173-179.
47. A agonist, muscimol, increase voluntary ethanol intake in Wistar rats. Neuropharmacology 33, 349-358.
48. 3 antagonist ondansetron on voluntary ethanol intake in rats and mice maintained on a limited access procedure. Psychopharmacology 117, 479-485.
49. Volpicelli, J. R., Alterman, A. I., Hayashida, M. and O'Brien, C. P. (1992) Naltrexone in the treatment of alcohol dependence. Archives of General Psychiatry 49, 876-880.
50. 3 receptors attenuates the effects of ethanol on extracellular dopamine. European Journal of Pharmacology 187, 287-289.
51. Yoshimoto, K. and McBride, W. J. (1992) Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat. Neurochemical Research 17, 401-407.