The collagen-like component of the complement system, C1q, is recognized by 7 S autoantibodies and is functionally impaired in synovial fluids of patients with rheumatoid arthritis

Immunology

Volumn 87, Issue 3, 1996, Pages 355-361

  Trinder, P K E ^a   Maeurer, M J ^a   Brackertz, D ^b   Loos, M ^a,c  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b St Vinzenz und Elizabeth Hospital   (Germany)

^c Inst of Med Microbiol and Hygiene   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; COLLAGEN; COMPLEMENT COMPONENT C1Q; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; SYNTHETIC PEPTIDE;

ARTICLE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

EID: 0029936747     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1996.495559.x     Document Type: Article

References (37)

1. STEFFEN C. (1970) Consideration of pathogenesis of rheumatoid arthritis as collagen autoimmunity. Z Immun Forsch 139, 219.
2. JASIN H.E. (1985) Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum 28, 241.
3. TARKOWSKI A., KLARESKOG L., CARLSTEN H. et al. (1989) Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis. Arthritis Rheum 32, 1087.
4. WATSON W.C., CREMER M.A., WOOLEY P.H. et al. (1986) Assessment of the potential pathogenicity of type II collagen autoantibodies in patients with rheumatoid arthritis. Evidence of restricted IgG3 subclass expression and activation of complement C5 to C5a. Arthritis Rheum 29, 1316.
5. TRENTHAM D.E., TOWNES A.S. & KANG A.H. (1977) Autoimmunity to type II collagen: an experimental model of arthritis. J Exp Med 146, 857.
6. LOOS M. (1982) The classical complement pathway: mechanism of activation of the first component by antigen antibody complexes. Prog Allergy 30, 135.
7. HEINZ H.-P., BRACKERTZ D. & LOOS M. (1988) Enzymatic alteration of C1q, the collagen-like subcomponent of the first component of complement, leads to cross-reactivity with type II collagen. FEBS Lett 228, 332.
8. HEINZ H.P., RUBIN K., LAURELL A.-B. et al. (1989) Common epitopes in C1q and collagen type II. Molec Immunol 26, 163.
9. BURKHARDT H., SCHWINGEL M., MENNINGER H. et al. (1986) Oxygen radicals as effectors of cartilage destruction. Arthritis Rheum 29, 379.
10. LUNEC J., HALLORAN S.P., WHITE A.G. & DORMANDY T.L. (1981) Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis. J Rheumatol 8, 379.
11. MAEURER M.J., TRINDER P.K.E., STÖRKEL S. & LOOS M. (1993) Clq in autoimmune disease: Rheumatoid arthritis. Behring Inst Mitt 93, 262.
12. ANTES U., HEINZ H.-P. & LOOS M. (1988) Evidence for the presence of autoantibodies to the collagen-like portion of C1q in systemic lupus erythematosus. Arthritis Rheum 31, 457.
13. SIEGERT C.E.H., DAHA M.R., VAN DER HOORT E.A.M. & BREEDVELD F.C. (1990) IgG and IgA antibodies to the collagen-like region of C1q in rheumatoid vasculitis. Arthritis Rheum 33, 1646.
14. ARNETT F.C., EDWORTH S.M., BLOCH D.A. et al. (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31, 315.
15. BRADFORD M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein. Analyt Biochem 72, 248.
16. STEMMER F. & LOOS M. (1984) Purification and characterization of human, guinea pig and mouse C1q by fast protein liquid chromatography (FPLC). J Immunol Meth 74, 9.
17. MYERS L.K., STUART J.M., SEYER J.M. et al. (1989) Identification of an immunosuppressive epitope of type II collagen that confers protection against collagen-induced arthritis. J Exp Med 170, 1999.
18. MAEURER M.J., TRINDER P.K.E. & LOOS M. (1992) Arthritis-regulating determinants on the collagen-like complement component C1q. Immunol Today 13, 278.
19. LAEMMLI U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680.
20. REID K.B.M. (1976) Isolation by partial pepsin digestion of the three collagen-like regions present in subcomponent C1q of the first component of human complement. Biochem J 155, 5.
21. HEINZ H.-P., BURGER R., GOLAN M.D. et al. (1984) Activation of the first component of complement, C1, by a monclonal antibody recognizing the C-chain of C1q. J Immunol 132, 804.
22. GOLAN M.D., HITSCHOLD T. & LOOS M. (1981) Enzyme linked immunosorbent assay for C1, the first complement component. FEBS Lett 128, 281.
23. NYDEGGER U.E. & SVEHAG S.E. (1984) Improved standardization in the quantitative estimation of soluble immune complexes making use of an international reference preparation. Results of a collaborative multicentre study. Clin Exp Immunol 58, 502.
24. HAY F.C., NINEHAM C.J. & ROITT I.M. (1976) Routine assay for the detection of immune complexes of known immunoglobulin class using solid phase C1q. Clin Exp Immunol 24, 396.
25. ANTES U., HEINZ H.-P. & LOOS M. (1987) Detection of C1q-bearing immune complexes by a monclonal anti-C1q ELISA system. J Immunol Meth 102, 149.
26. ANTES U., HEINZ H.-P., SCHULTZ D. et al. (1991) C1q-bearing immune complexes detected by a monoclonal antibody to human C1q in rheumatoid arthritis sera and synovial fluids. Rheumatol Int 10, 245.
27. ANTES U., HEINZ H.-P. & LOOS M. (1984) Enzyme-linked immunosorbent assay for C1q in human serum by use of monoclonal antibodies. J Immunol Meth 74, 299.
28. MILGROM F., TÖNDER O. & LOZA U. (1964) Modification of the Waaler-Rose-Test using formalinized sheep erythrocytes. Arthritis Rheum 7, 1.
29. HEINZ H.-P. & EIBL C. (1989) C1q as radical scavenger. Compl Inflamm 6, 343(A).
30. HOEKZEMA R., HANNEMA A.J., SWAAK T.J.G., PAARDEKOOPER J. & HACK C.E. (1985) Low molecular weight C1q in systemic Lupus erythematosus. J Immunol 135, 265.
31. 2-complex but which does not bind to Fc in immunoglobulin aggregates. Molec Immunol 25, 1231.
32. TERATO K., HASTY K.A., CREMER M.A. et al. (1985) Collagen-induced arthritis in mice. Localization of an arthritogenic determinant to a fragment of the type II collagen. J Exp Med 162, 637.
33. MAEURER M.J., TRINDER P.K.E., STÖRKEL S. et al. (1992) Modulation of type II collagen-induced arthritis in DBA/1 mice by intravenous application of a peptide from the C1q-A chain. Immunobiol 185, 103.
34. MYERS L.K., TERATO K., SEYER J.M. et al. (1992) Characterization of a tolerogenic T cell epitope of type II collagen and its relevance to collagen-induced arthritis. J Immunol 149, 1439.
35. ROSLONIEC E.F., MYERS L.K., BRAND D.D. et al. (1993) Characterization of type II collagen antigenic determinants presented by a CIA susceptible class II allele. J Cell Biochem (Suppl) 17B, 135(A).
36. BERLING J. & LAMBERT L. (1993) Structural requirements for T cell recognition of a type II collagen peptide. J Immunol 150, 42(A).
37. SAITTA M.R., ARNETT F.C. & KEENE J.D. (1994) 60-kDa Ro protein autoepitopes identified using recombinant polypeptides. J Immunol 152, 4192.