Maximal androgen blockade in combination with methotrexate for treatment of metastatic prostate cancer

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 3, 1996, Pages 171-176

  Sagaster, Peter ^a   Flamm, Johannes ^a   Micksche, Michael ^b   Fritz, Elke ^a   Donner, Gerhard ^c   Ludwig, Heinz ^a  

^a Wilhelminenspital ^*  (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c GENERAL HOSPITAL   (Austria)

Author keywords

Maximal androgen blockade; Methotrexate; Prostate cancer; Randomized trial

Indexed keywords

FLUTAMIDE; METHOTREXATE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; MAJOR CLINICAL STUDY; MALE; METASTASIS; ORAL DRUG ADMINISTRATION; ORCHIECTOMY; PRIORITY JOURNAL; PROSTATE CANCER; RANDOMIZED CONTROLLED TRIAL;

AGED; ANDROGEN ANTAGONISTS; ANTINEOPLASTIC AGENTS, HORMONAL; COMBINED MODALITY THERAPY; FLUTAMIDE; HUMANS; MALE; METHOTREXATE; MIDDLE AGED; ORCHIECTOMY; PROSPECTIVE STUDIES; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS;

EID: 0029936568     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01366958     Document Type: Article

References (18)

1. Armitage P (1958) Sequential methods in clinical trials. Am J Public Health 48:1395-1402
2. Crawford ED, Eisenberger MA, McLeod DG, Spaulding, JT. Benson R, Dorr FA, Blumenstein BA, Davis MA, Goodman PJ (1989) A controlled trial of leuprolide with and without flutamide in prostatic carcinoma, N Engl J Med 321:419-424
3. Daneshgari F. Crawford ED (1993) Endocrine therapy of advanced carcinoma of the prostate. Cancer 71:1089-1097
4. Goldrath DH, Messing EM (1989) Prostate specific antigen: not detectable despite tumor progression after radical prostatectomy. J Urol 142:1082-1084
5. Huben RP, Murphy GP (1988) A comparison of diethylstilbestrol or orchiectomy with buserelin and with methotrexate plus diehtylstilbestrol or orchiectomy in newly diagnosed patients with clinical stage D2 cancer of the prostate. Cancer 62:1881-1887
6. Huggins C, Hodges CV (1972) Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. CA 22:232-240
7. Isaacs JT (1984) The timing of androgen ablation therapy and or chemotherapy in the tretment of prostatic cancer. Prostate 5:1-17
8. Janknegt RA, Abbou CC, Barloletti R, Bernstein-Hahn L, Bracken B, Brisset JM, Calais Da Silva F, Chisholm G, Crawford ED, Debruyne J, Dijkman GD, Frick J, Goedhals L, Knoenagel H, Venner PM (1993) Orchiectomy and nilutamide or placebo as treatment of metastatic prostatic cancer in a multinational double-blind randomized trial. J Urol 149:77-82
9. Koutsilieris M, Faure N, Tolis G, Laroche B, Robert G, Ackman CF (1986) Objective response and disease outcome in 59 patients with stage D2 prostatic cancer treated with either Buserelin or orchiectomy. Disease aggressivity and its association with response and outcome. Urology 27:221-228
10. Labrie F, Dupont A, Belanger A, Cusan L, Lacourciere Y, Monfette G, Laberge JG, Edmond JP, Fazekas ATA, Raynaud JP, Husson JM (1982) New hormonal therapy in prostatic carcinoma: combined treatment with an LHRH agonist and an antiandrogen. Clin Invest Med 5:267-275
11. Loening SA, Beckley S, Brady MF, Chu TM, deKernion JB, Dhabuwala C, Gaeta JF, Gibbons RP, Mc Kiel CF, Mc Leot DG, Pontes JE, Prout GR, Cardino PT, Schlegel JU, Schmidt JD, Scott WW, Slack NH (1983) Comparison of estramustine phosphate, methotrexate and cis-platinum in patients with advanced, hormone refractory prostate cancer. J Urol 129:1001-1006
12. Murphy GP, Beckley S, Brady MF, Chu TM, deKernion HB, Dhabuwala C, Gaeta JF, Gibbons RP, Loening SA, McKiel CF, McLeod DG, Pontes JE, Prout GR, Scardino IE, Schlegel JU, Schmidt JD, Scott WW, Slack NH, Soloway MS (1983) Treatment of newly diagnosed metastatic prostate cancer patients with chemotherapy agents in combinations with hormones versus hormones alone. Cancer 51:1264-1272
13. Murphy GP, Huben RP, Priore R (1986) Results of another trial of chemotherapy with and without hormones in patients with newly diagnosed metastatic prostate cancer. Urology 28:36-40
14. Osborne CK, Blumenstein B. Crawford ED, Coltman CA Jr, Smith AY, Lambuth BW, Chapman RA (1990) Combined versus sequential chemo-endocrine therapy in advanced prostate cancer: final results of a randomized Southwest Oncology Group study. J Clin Oncol 8:1675-1682
15. Van Popel H, van den Broucke F, Derluyn J, Popelier G, Casselman J, Billiet I, van Uytsel L, Paridaens R, Baert L (1993) Mitomycin C in combination with orchiectomy for newly diagnosed metastatic prostate cancer: preliminary results on a randomized trial. J Urol 149:1485-1487
16. UICC (1987) TNM-Klassifikation maligner Tumoren. Hermanek P, Scheibe O, Spiessl B, Wagner G (eds) International Union Against Cancer (UICC). Springer, Berlin Heidelberg New York
17. WHO (1979) Handbook for Reporting Results of Cancer Treatment. WHO Offset Publ. 48
18. Yagoda A, Petrylak D (1993) Cytotoxic chemotherapy for advanced hormone-resistant prostate cancer. Cancer 71:1098-1109