Thrombospondin peptides inhibit the secretion-dependent phase of platelet aggregation

Blood Coagulation and Fibrinolysis

Volumn 7, Issue 2, 1996, Pages 237-240

  Rabhi Sabile, S ^a   Thibert, V ^a   Legrand, C ^a,b  

^a INSERM   (France)

^b SAINT LOUIS HOSPITAL   (France)

Author keywords

Peptides; Platelet aggregation; Thrombosis; Thrombospondin

Indexed keywords

ANTICOAGULANT AGENT; SYNTHETIC PEPTIDE; THROMBOSPONDIN;

CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOSIS;

EID: 0029936163     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-199603000-00032     Document Type: Conference Paper

References (16)

1. Shattil SJ, Ginsberg MH, Brugge JS. Adhesive signaling in platelets. Curr Op Cell Biol 1994; 6: 695-704.
2. Heilman E, Hourdillé P, Pruvost A, et al. Thrombin-induced platelet aggregates have a dynamic structure. Time-dependent redistribution of glycoprotein IIb-IIIa complexes and secreted adhesive proteins. Arterioscler Thromb 1991; 11: 704-718.
3. Murphy-Ullrich JE, Mosher DF. Localization of thrombospondin in clots formed in situ. Blood 1985; 66: 1098-1104.
4. Leung LLK. Role of thrombospondin in platelet aggregation. J Clin Invest 1984; 74: 1764-1772.
5. Lahav J. The functions of thrombospondin and its involvement in physiology and pathophysiology. Biochim Biophys Acta 1993; 1182: 1-14.
6. Legrand C, Morandi V, Mendelovitz S, et al. Selective inhibition of platelet macroaggregate formation by a recombinant heparin-binding domain of human thrombospondin. Arteriosclerosis Thromb 1994; 14: 1784-1791.
7. Tuszynski GP, Rothman VL, Deutch AH, et al. Biological activities of peptides and peptide analogues derived from common sequences present in thrombospondin, properdin, and malarial proteins. J Cell Biol 1992; 116: 209-217.
8. Gartner TK, Walz DA, Aiken M, et al. Antibodies against a 23 kD heparin binding fragment of thrombospondin inhibit platelet aggregation. Biochem Biophys Res Commun 1984; 124: 290-295.
9. Dixit VM, Harvestick DM, O'Rourke KM, et al. A monoclonal antibody against human thrombospondin inhibits platelet aggregation. Proc Natl Acad Sci USA 1985; 82: 3472-3476.
10. Legrand C, Thibert V, Dubernard V, et al. Molecular requirements for the interaction of thrombospondin with thrombin-activated human platelets: modulation of platelet aggregation. Blood 1992; 79: 1995-2003.
11. Asch AS, Silbiger S, Heimer E, Nachman RL. Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding. Biochem Biophys Res Commun 1992; 182: 1208-1217.
12. Catimel B, Leung L, el Ghissasi H, et al. Human platelet glycoprotein IIIb binds to thrombospondin fragments bearing the C-terminal region, and/or the type I repeats (CSVTCG motif), but not to the N-terminal heparin-binding region. Biochem J 1992; 284: 231-236.
13. Rich KA, George IV FW, Law JL, Martin WJ. Cell-adhesive motif in region II of malarial circumsporozoite protein. Science 1990; 249: 1574-1577.
14. Legrand C, Dubernard V, Nurden AT. Studies on the role and surface expression of platelet fibrinogen on activated cells. In: Lowe GDO et al., eds. Fibrinogen 2, Biochemistry, Physiology and Clinical Relevance. Elsevier Science Publishers, 1987: 143-147.
15. Savage B, Marzec UM, Chao BH, et al. Binding of the snake venom-derived proteins applaggin and echistatin to the Arginine-Glycine-Aspartic acid recognition site(s) on platelet glycoprotein Ilb-IIIa complex inhibits receptor function. J Biol Chem 1990; 265: 11766-11772.
16. Huang M-M, Bolen JB, Barnwell JW, et al. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn and Yes protein-tryosine kinases in human platelets. Proc Natl Acad Sci USA 1992; 88: 7844-7848.