An improved synthesis of the unique anti-migraine agent CP-122,288: A bromine atom passenger in an intramolecular Heck reaction

Tetrahedron Letters

Volumn 37, Issue 25, 1996, Pages 4289-4292

  Macor, John E ^a,c   Ogilvie, Ron J ^b   Wythes, Martin J ^b  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c Astra Arcus USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLAMINOSULFONYLMETHYL 3 (1 METHYL 2 PYRROLIDINYLMETHYL) 1H INDOLE; ANILINE DERIVATIVE; ANTIMIGRAINE AGENT; BROMINE DERIVATIVE; CP 122638; INDOLE DERIVATIVE; SUMATRIPTAN; SUMATRIPTAN SUCCINATE; UNCLASSIFIED DRUG;

ARTICLE; BROMINATION; CRYSTALLIZATION; CYCLIZATION; DRUG POTENCY; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HEATING; REDUCTION; THIN LAYER CHROMATOGRAPHY;

EID: 0029935975     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00322-X     Document Type: Article

References (6)

1. Hopkins, S.J. Drugs of Today 1992, 28, 155, and references cited within.
2. Macor, J.E.; Blank, D.H.; Post, R.J.; Ryan, K. Tetrahedron Letters 1992, 33, 8011.
3. Lee, W.S. and Moskowitz, M.A. Brain Research 1993, 626, 303.
4. Harrington, P.J.; Hegedus, L.S.; McDaniel, K.F. J. Am. Chem. Soc. 1987, 109, 4335.
5. 2S · 0.25 ethyl acetate: C, 48.34; H, 5.73; N, 9.95. Found: C, 48.20; H, 5.70; N, 9.85.
6. It should be noted by the reader that 7a (X=H) is, in fact, CP-122,288.