Generation of a free radical from calphostin C by microsomal cytochrome P450 reductase in rat and human liver

Biochemical Pharmacology

Volumn 51, Issue 5, 1996, Pages 599-603

  Patterson, Laurence H ^a   Jones, Sarah ^a   Gescher, Andreas ^b  

^a DE MONTFORT UNIVERSITY   (United Kingdom)

^b NONE

Author keywords

calphostin C; cyt P450 reductase; esr; free radical; human liver

Indexed keywords

CALPHOSTIN C; CYTOCHROME P450 REDUCTASE; FREE RADICAL; PROTEIN; PROTEIN KINASE C INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; HUMAN; HUMAN TISSUE; LIVER MICROSOME; NONHUMAN; PHOTOACTIVATION; PRIORITY JOURNAL; RAT;

EID: 0029935723     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(95)02180-9     Document Type: Article

References (11)

1. Gescher A, Towards selective pharmacological modulation of protein kinase C - opportunities for the development of novel antineoplastic agents. Brit J Cancer 66: 10-19, 1992.
2. Tamaoki T, Nomoto H, Takahashi I, Kato Y, Morimoto M and Tomita F, Staurosporine, a microbial compound is a highly potent and specific inhibitor or protein kinase C from streptomyces. Biochem Biophys Res Commun 135: 397-402, 1986.
3. Kobayashi E, Nakano H, Morimoto M and Tamaoki T, Calphostin C (UCN-1028C) a novel microbial compound is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159: 548-553, 1989.
4. Tamaoki T and Nakano H, Potent and specific inhibitors of protein kinaseC of microbial origin. Biotechnology 8: 732-735, 1990.
5. Bruns RF, Miller FD, Mirriman RL, Howbert JJ, Heat WF, Kobayashi E, Takahashi I, Tamaoki T, and Nakano H, Inhibition of protein kinase C by calphostin C is light-dependent. Biochem Biophys Res Commun 176: 288-293, 1991.
6. Diwu Z, Zimmermann J, Meyer TH and Lown JW, Design, synthesis and investigation of mechanism of action of novel protein kinase C inhibitors: perylenequinoid pigments. Biochem Pharmacol 47: 373-385, 1994.
7. Diwu Z and Lown JW, Photosensitization with anticancer agents 19. EPR studies of photodynamic action of calphostin C: formation of semiquinone radical and activated oxygen on illumination with visible light. Free Rad Biol Med 16: 645-652, 1994.
8. Basra J, Wolf CR, Brown JR, and Patterson LH, Evidence for human liver microsome free radical formation by doxorubicin and mitoxantrone. Anti-cancer Drug Design 1: 45-52, 1985.
9. Sinha BK, Free radicals in anticancer drug pharmacology. ChemBiol Interact 69: 293-317, 1989.
10. Tew DG, Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications. Biochemistry 32: 10209-10215, 1993.
11. Kappus H, Overview of enzyme systems involved in bioreduction of drugs and in redox cycling. Biochem Pharmacol 35: 1-6, 1986.