RNA editing: How a message is changed

Current Opinion in Genetics and Development

Volumn 6, Issue 2, 1996, Pages 221-231

  Benne, Rob ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; APOLIPOPROTEIN B; CYTIDINE DEAMINASE; DEAMINASE; DOUBLE STRANDED RNA; GLUTAMATE RECEPTOR; INOSINE; MESSENGER RNA; MITOCHONDRIAL RNA; MUTANT PROTEIN; ZINC;

CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE DELETION; GENE INSERTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; PROTOZOON; REVIEW; RNA EDITING;

EID: 0029935695     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)80054-2     Document Type: Article

References (99)

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97. Lukes J, Arts GJ, Van den Burg J, De Haan A, Opperdoes F, Sloof P, Benne R: Novel pattern of editing reigons in mitochondrial transcripts of the cryptobiid Trypanoplasma borreli. EMBO J 1994, 13:5086-5098.
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99. Casey JL, Gerin JL: Hepatitis D virus RNA editing: specific modification of adenosine in the antigenomic RNA. J Virol 1995, 69:7593-7600. It was long unclear whether the editing of HDV RNA is the result of a U to C transition in the genomic strand or an A modification (to I or G) in the antigenomic strand. In this paper the confusion is resolved through the analysis of non-replicating genomic and antigenomic HDV RNAs, the results of which favor mechanisms invoking editing by A deamination of the antigenomic strand. Analogous to GluR-B mRNA editing, HDV RNA editing requires basepairing, making dsRAD a likely candidate enzyme in this case too.