Benextramine acts as an irreversible noncompetitive antagonist of U46619-mediated contraction of the rat small mesenteric artery

European Journal of Pharmacology

Volumn 300, Issue 3, 1996, Pages 211-214

  Van Der Graaf, Pieter H ^a,b   Stam, Wiro B ^b   Saxena, Pramod R ^b  

^a SANOFI   (France)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

benextramine; mesenteric artery; prostanoid TP receptor; rat; small; SQ 30,741; U46619

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 7 [3 [(2 HEPTANAMIDOACETAMIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ARGIPRESSIN; BENEXTRAMINE; INDOMETACIN; METHYLFURTRETHONIUM; PROSTANOID TP RECEPTOR ANTAGONIST; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG MECHANISM; ISOLATED ARTERY; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029935258     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00040-4     Document Type: Article

References (15)

1. Baxter, G.S., J.K. Clayton, R.A. Coleman, K. Marshall, R. Sangha and J. Senior, 1995, Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery, Br. J. Pharmacol. 116, 1692.
2. Coleman, R.A., W.L. Smith and S. Narumiya, 1994, International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes, Pharmacol. Rev. 46, 205.
3. Elliot, S.R. and W.J. Pearce, 1994, Effects of maturation on α-adrenergic receptor affinity and occupancy in small cerebral arteries, Am. J. Physiol. 267 (Heart Circ. Physiol. 36), H757.
4. Furchgott, R.F., 1954, Dibenamine blockade in strips of rabbit aorta and its use in differentiating receptors, J. Pharmacol. Exp. Ther. 111, 265.
5. Furchgott, R.F., 1966, The use of β-haloalkylamines in the differentiation of dissociation constants of receptor-agonist complexes, Adv. Drug Res. 3, 21.
6. Jenkinson, D.H., E.A. Barnard, D. Hoyer, P.P.A. Humphrey, P. Leff and N.P. Shankley, 1995, International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. IX. Recommendations on terms and symbols in quantitative pharmacology, Pharmacol. Rev. 47, 255.
7. Melchiorre, C., 1981, Tetramine disulfides: a new tool in α-adrenergic pharmacology, Trends Pharmacol. Sci. 2, 209.
8. Mulvany, M.J. and W. Halpem, 1977, Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats, Circ. Res. 41, 19.
9. Ogletree, M.L. and G.T. Allen, 1992, Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles, J. Pharmacol. Exp. Ther. 260, 789.
10. 1 receptor subtypes present in rabbit isolated vas deferens and saphenous vein, Br. J. Pharmacol. 115, 3.
11. Plotek, Y. and D. Atlas, 1983, Characterization of benextramine as an irreversible a-adrenergic blocker and as a blocker of potassium-activated calcium channels, Eur. J. Biochem. 133, 539.
12. Schumacher, W.A., C.L. Heran, H.J. Goldenberg, D.N. Harris and M.L. Ogletree, 1989, Magnitude of thromboxane receptor antagonism necessary for antithrombotic activity in monkeys, Am. J. Physiol. 256 (Heart Circ. Physiol. 25), H726.
13. 2 receptors: evidence from benextramine protection studies, J. Pharmacol. Exp. Ther. 265, 172.
14. 1-vascular vasopressin receptors, Regul. Pept. 38, 1.
15. Wang, Y., A. Mercer-Connolly, L. Lines, O. Toyoda and F. Coceani, 1994. Endothelium-denuded pulmonary resistance arteries from the fetal lamb: preparation and response to vasoactive agents, J. Pharmacol. Toxicol. Methods 32, 85.