Translation is enhanced after silent nucleotide substitutions in A+T-rich sequences of the coding region of CD46 cDNA

European Journal of Biochemistry

Volumn 238, Issue 1, 1996, Pages 221-230

  Milland, Julie ^a   Christiansen, Dale ^a   Thorley, Bruce R ^a   Mckenzie, Ian F C ^a   Loveland, Bruce E ^a  

^a AUSTIN RESEARCH INSTITUTE   (Australia)

Author keywords

A+T rich; CD46; Protein engineering; Silent nucleotide substitution; Translation rate

Indexed keywords

MEMBRANE COFACTOR PROTEIN; MESSENGER RNA; PLASMID DNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENETIC ENGINEERING; GENETIC TRANSFECTION; HUMAN; IN VITRO STUDY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SEQUENCE; RNA TRANSLATION; START CODON;

EID: 0029934697     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0221q.x     Document Type: Article

References (62)

1. Moldave, K. (1985) Eukuryotic protein synthesis, Annu. Rev. Biochem. 54, 1109-1149.
2. Hershey, J. W. B. (1991) Translational control in mammalian cells, Annu. Rev. Biochem. 60, 717-755.
3. Kozak, M. (1991) An analysis of vertebrate mRNA sequences: intimations of translational control, J. Cell. Biol. 115, 887-903.
4. Kozak, M. (1986) Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes, Cell 44, 283-292.
5. Kozak, M. (1989) Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems, Mol. Cell Biol. 9, 5073-5080.
6. Boeck, R. & Kolakofsky, D. (1994) Positions +5 and +6 can be major determinants of the efficiency of non-AUG initiation codons for protein synthesis, EMBO J. 13, 3608-3617.
7. Grunert, S. & Jackson, R. J. (1994) The immediate downstream codon strongly influences the efficiency of utilization of eukaryotic translation initiation codons, EMBO J. 13, 3618-3630.
8. Geballe, A. P. & Morris, D. R. (1994) Initiation codons within 5′-leaders of mRNAs as regulators of translation, Trends Biochem. Sci. 19, 159-164.
9. Sonenberg, N. (1993) Translation factors as effectors of cell growth and tumorigenesis, Curr. Opin. Cell. Biol. 5, 955-60.
10. Sonenberg, N. (1994) mRNA translation: influence of the 5′ and 3′ untranslated regions, Curr. Opin. Genet. Dev. 4, 310-315.
11. Pause, A., Belsham, G. J., Gingras, A.-C., Donze, O., Lin, T.-A., Lawrence, J. C. Jr & Sonenberg, N. (1994) Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function, Nature 371, 762-767.
12. de-Boer, H. A. & Hui, A. S. (1990) Sequences within ribosome binding site affecting messenger RNA translatability and method to direct ribosomes to single messenger RNA species, Methods Enzymol. 185, 103-114.
13. Liszewski, M. K., Post, T. W. & Atkinson, J. P. (1991) Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster, Annu. Rev. Immunol. 9, 431-455.
14. Naniche, D., Varior-Krishnan, G., Cervoni, F., Wild, T. F. Rossi, B., Rabourdin-Combe, C. & Gerlier, D. (1993) Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus, J. Virol. 67, 6025-6032.
15. Dorig, R. E., Marcil, A., Chopra, A. & Richardson, C. D. (1993) The human CD46 molecule is a receptor for measles virus (Edmonston strain), Cell 75, 295-305.
16. Hourcade, D., Holers, M. V. & Atkinson, J. P. (1989) The regulators of complement activation (RCA) gene cluster, Adv. Immunol. 45, 381-416.
17. Hourcade, D., Garcia, A. D., Post, T. W., Taillon-Miller, P., Holers, M. V., Wagner, L. M., Bora, N. S. & Atkinson, J. P. (1992) Analysis of the human regulators of complement activation (RCA) gene cluster with yeast artificial chromosomes (YACS), Genomics 12, 289-300.
18. Quilliam, A. L., Osman, N., McKenzie, I. F. C. & Hogarth, P. M. (1993) Biochemical characterization of murine FcγRI, Immunology 78, 358-363.
19. Bode, J., Kohwi, Y., Dickinson, L., Joh, T., Klehr, D., Mielke, C. & Kohwi-Shigematsu, T. (1992) Biological significance of unwinding capability of nuclear matrix-associating DNAs, Science 255, 195-197.
20. Christofori, G. & Keller, W. (1988) 3′ cleavage and polyadenylation of mRNA precursors in vitro requires a poly(A) polymerase, a cleavage factor, and a snRNP, Cell 54, 875-889.
21. Takagaki, Y., MacDonald, C. C., Shenk, T. & Manley, J. L. (1992) The human 64-kDa polyadenylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs, Proc. Natl Acad. Sci. USA 89, 1403-1407.
22. Sachs, A. B. (1993) Messenger RNA degradation, Cell 74, 413-421.
23. Lagnado, C. A., Brown, C. Y. & Goodall, G. J. (1994) AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A), Mol. Cell. Biol. 14, 7984-7995.
24. Zubiaga, A. N., Belasco, J. G. & Greenberg, M. E. (1995) The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation, Mol. Cell. Biol. 15, 2219-2230.
25. Sachs, A. B. & Davis, R. W. (1990) The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation, Cell 58, 857-867.
26. Munroe, D. & Jacobson, A. (1990) mRNA poly(A) tail, a 3′ enhancer of translational initiation, Mol. Cell. Biol. 10, 3441-3455.
27. Jackson, R. J. & Standart, N. (1990) Do the poly(A) tail and 3′ untranslated region control mRNA translation? Cell 62, 15-24.
28. Gallie, D. R. (1991) The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency, Genes & Dev. 5, 2108-2116.
29. Gallie, D. R. & Tanguay, R. (1994) Poly(A) binds to initiation factors and increases cap-dependent translation in vitro, J. Biol. Chem. 269, 17 166-17 173.
30. Schiavi, S. C., Wellington, C. L., Shyu, A. B., Chen, C. Y., Greenberg, M. E. & Belasco, J. G. (1994) Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation, J. Biol. Chem. 269, 3441-3448.
31. Russell, S. M. Sparrow, R. L., McKenzie, I. F. C. & Purcell, D. F. (1992) Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing, Eur. J. Immunol. 22, 1513-1518.
32. Purcell, D. F. J., Russell, S. M., Deacon, N. J., Brown, M. A., Hooker, D. J. & McKenzie, I. F. C. (1991) Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation, Immunogenetics 33, 335-344.
33. Horton, R. M., Hunt, H. D., Ho, S. N., Pullen, J. K. & Pease, L. R. (1989) Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension, Gene 77, 61-68.
34. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular cloning: a laboratory manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
35. Sparrow, R. L. & McKenzie, I. F. C. (1983) HuLy-m5: a unique antigen physically associated with HLA molecules, Hum. Immunol. 7, 1-5.
36. Seya, T., Hara, T., Uenaka, A., Nakayama, E. & Akedo, H. (1990) Application of protein A-rosette assay for screening of monoclonal antibodies to human complement regulatory proteins, Complement Inflamm. 7, 78-89.
37. Stefanova, I., Hilgert, I., Kristofova, H., Brown, R., Low, M. G. & Horejsi, V. (1989) Characterisation of a broadly expressed human leukocyte surface antigen MEM-43 anchored in the membrane through phosphotidylinositol, Mol. Immumol. 26, 153-161.
38. Johnstone, R. W., Russell, S. M., Loveland, B. E. & McKenzie, I. F. C. (1993) Polymorphic expression of CD46 protein isoforms due to tissue-specific RNA splicing, Mol. Immunol. 30, 1231-1241.
39. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227, 680-684.
40. Johnstone, R. W., Loveland, B. E. & McKenzie, I. F. (1993) Identification and quantification of complement regulator CD46 on normal human tissues, Immunology 79, 341-347.
41. Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J. & Rutter, W. J. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry 18, 5294-5299.
42. Milland, J., Tsykin, A., Thomas, T., Aldred, A. R., Cole, T. & Schreiber, G. (1990) Gene expression in regenerating and acute-phase rat liver, Am. J. Physiol. 259, G340-G347.
43. Koetsier, P. A., Schorr, J. & Doerfler, W. (1993) A rapid optimized protocol for downward alkaline Southern blotting of DNA, Biotechniques 15, 260-262.
44. Coligan, J. E., Gates, F. T. III, Kimball, E. S. & Maloy, W. L. (1983) Radiochemical sequence analysis of biosythelically labeled proteins, Methods Enzymol. 91, 413-434.
45. Kaufman, R. J., Davies, M. V., Pathak, V. K. & Hershey, J. B. (1989) The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs, Mol. Cell. Biol. 9, 946-958.
46. Theodorakis, N. G., Banerji, S. S. & Morimoto, R. I. (1988) Hsp70 mRNA translation in chicken reticulocytes is regulated at the level of elongation, J Biol. Chem. 263, 14 579-14 585.
47. Negrutskii, B. S. & Deutscher, M. P. (1991) Channeling of aminoacyl-tRNA for protein synthesis in vivo, Proc. Natl Acad. Sci. USA 88, 4991-4995.
48. Negrutskii, B. S. & Deutscher, M. P. (1992) A sequestered pool of aminoacyl-tRNA in mammalian cells, Proc. Natl Acad. Sci. USA 89, 3601-3604.
49. Negrutskii, B. S., Stapulionis, R. & Deutscher, M. P. (1994) Supramolecular organization of the mammalian translation system, Proc. Natl Acad. Sci. USA 91, 964-8.
50. Wada, K.-n., Aota, S.-i., Tsuchiya, R., Ishibashi, F., Gojobori, T. & Ikemura, T. (1990) Codon usage tabulated from the GenBank genetic sequence data, Nucleic Acids Res. 18 Suppl., 2367-2411.
51. Jackson, R. J. & Hunt, T. (1983) Preparation and use of nuclease-treated rabbit reticulocyte lysates for the translation of eukaryotic messenger RNA, Methods Enzymol. 96, 50-74.
52. Loveland, B. E., Johnstone, R. W., Russell, S. M., Thorley, B. R. & McKenzie, I. F. (1993) Different membrane cofactor protein (CD46) isoforms protect transfected cells against antibody and complement mediated lysis, Transpl. Immunol. 1, 101-108.
53. Sharp, P. M., Cowe, E., Higgins, D. G., Shields, D. C., Wolfe, K. H. & Wright, F. (1988) Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; a review of the considerable within-species diversity, Nucleic Acids Res. 16, 8207-8211.
54. Stenico, M., Lloyd, A. T. & Sharp, P. M. (1994) Codon usage in Caenorhabditis elegans: delineation of translational selection and mutational biases, Nucleic Acids Res. 22, 2437-2446.
55. Eyre-Walker, A. C. (1991) An analysis of codon usage in mammals: selection or mutation bias? J. Mol. Evol. 33, 442-449.
56. Ruiz-Linares, A., Bouloy, M., Girard, M. & Cahour, A. (1989) Modulations of the in vitro translational efficiencies of yellow fever virus mRNAs: interactions between coding and noncoding regions, Nucleic Acids Res. 17, 2463-2476.
57. Dandekar, T. & Hentze, M. W. (1995) Finding the hairpin in the haystack: searching for RNA motifs, Trends Genet. 11, 45-50.
58. Burd, C. G. & Dreyfuss, G. (1994) Conserved structures and diversity of functions of RNA-binding proteins, Science 265, 615-621.
59. Minich, W. B., Korneyeva, N. L., Berezin, Y. V. & Ovchinnikov, L. P. (1989) A special repressor/activator system controls distribution of mRNA between translationally active and inactive mRNPs in rabbit reticulocytes, FEBS Lett. 258, 227-229.
60. Foyt, H. L., LeRoith, D. & Roberts, C. Jr (1991) Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo, J. Biol. Chem. 266, 7300-7305.
61. Foyt, H. L., Lanau, F., Woloschak, M., LeRoith, D. & Roberts, C. Jr (1992) Effect of growth hormone on levels of differentially processed insulin-like growth factor I mRNAs in total and polysomal mRNA populations, Mol. Endocrinol. 6, 1881-1888.
62. Spirin, A. S. (1994) Storage of messenger RNA in eukaryotes: envelopment with protein, translational barrier at 5′ side, or conformational masking by 3′ side, Mol. Reprod. Dev. 38, 107-117.