Granulocyte labelling kit BW 250/183: Results of the European multicenter trial

NuklearMedizin

Volumn 35, Issue 1, 1996, Pages 1-11

  Steinstraßer A ^a   Oberhausen, E ^b  

^a SANOFI   (France)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

Clinical multicenter trial; Immunoscintigraphy; Inflammation scintigraphy; Monoclonal antibody BW 250 183; Technetium99m

Indexed keywords

MONOCLONAL ANTIBODY; TECHNETIUM 99M;

ANGIONEUROTIC EDEMA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ECZEMA; FEMALE; GRANULOCYTE; HUMAN; HYPOTENSION; IMMUNOSCINTIGRAPHY; ISOTOPE LABELING; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OSTEOMYELITIS; PHASE 1 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL;

ANIMALS; ANTIBODIES, MONOCLONAL; BONE DISEASES; EUROPE; GRANULOCYTES; HUMANS; IMMUNOGLOBULIN G; INFLAMMATION; MICE; RADIOIMMUNODETECTION; REAGENT KITS, DIAGNOSTIC; SENSITIVITY AND SPECIFICITY; TECHNETIUM; TISSUE DISTRIBUTION;

EID: 0029934647     PISSN: 00295566     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1629768     Document Type: Article

References (72)

1. 111In granulocytes for localization of inflammatory bowel disease. Acta Radiol 1992; 33: 140-4.
2. Atkins HL, Hauser W, Richards P. Klopper J. Adverse reactions to radiopharmaceuticals J Nucl Med 1972; 13: 232-3.
3. 99mTc-labelled Anti NCA-95 Antibodies in Prosthetic Heart Valve Endocarditis. Nucl Med 1991; 30: 149-50.
4. Bartenstein P, Kirchner B, Scheidhauer K, Schober O. Immunszintigraphie des hämatopoetischen Knochenmarks bei Osteomyelofibrose. Nucl Med 1990; 29: 180-2.
5. Becker W. Nuklearmedizinische Entzündungsdiagnostik. Dt Ärztebl 1991; 37: C 1687-92.
6. Becker W. Entzündungsszintigraphie mit autologen Leukozyten und murinen monoklonalen Antikörpern. Der Nuklearmediziner 1992; 4: 273-86.
7. Becker W. Dölkemeyer M. Gramatzki M. Schneider MU, Scheele J, Wolf F. Tc-99m-Antigranulozytenantikörper (NCA-95: BW 250/183) bei Patienten mit Fieber unklarer Genese. Nucl Med 1993; 32: A54.
8. Berberich R, Sutler M. Oberhausen E. Imaging of Inflammatory lesions with Tc-99m labelled Monoclonal Anti-Granulocytes Antibodies. Nucl Med 1989; Suppl 25:102-5.
9. Berberich R, Hennes P, Alexander C. Entzündungsnachweis und HAMA-Bildung nach Applikation des monoklonalen Antikörpers BW 250/183. Nucl Med 1992; 31: 70-3.
10. Berná L, Torres G, Carrió, Estorch M, Germa JR. Alonso C. Antigranulocyte Antibody Bone Marrow Scans in Cancer Patients with Metastatic Bone Superscan Appearance. Clin Nucl Med 1994; 19: 121-8.
11. Biersack HJ, Overbeck B, Ott G, Kania U, Briele B. Kropp J, Bockisch A, Grünwald F, et al. Tc-99m labelled Monoclonal Antibodies against Granulocytes (BW 250/183) in the detection of Appendicitis. Clin Nucl Med 1993; 18: 371-6.
12. Boßlet K, Lüben G, Schwarz A, Hundt E, Harthus HP, Seiler FR. Muhrer C, Klöppel G, Kayer K, Sedlacek H. Immunohistochemical Localization and Molecular Characteristics of three Monoclonal AntibodyDefined Epitopes Detectable on Carcinoembryunic Antigen (CEA). Int J Cancer 1985; 36: 75-84.
13. Diege-Petersen H. Safety aspects of human use of labelled cells. In: Safety and efficacy of radiopharmaceuticals. Kristensen K, Norbygaard E (eds). Martinus Nijhoff Publishers 1987. 207-16.
14. Dominguez-Gadea L, Martin-Curto LM, de la Calle H, Crespo A. Diabetic foot infections: scintigraphic evaluation with 99mTc-labelled anti-granulocyte antibodies. Nucl Med Commun 1993; 14: 212-8.
15. Duncker CM, Carrió I, Berna L, Estorch M, Alonso C, Ojeda B, Blanco R et al. Radioimmune Imaging of Bone Marrow in Patients with Suspected Bone Metastases from Primary Breast Cancer. J Nucl Med 1990; 31: 1450-5.
16. 99mTc-Antigranulozyten-Antikörper (AGAK) in einem Fall massiver periduraler Abszedierung. Nuc Compact 1989:20: 121-2.
17. Eising EG, Reiners C. Scintigraphic detection of infection: Are human anti-mouse antibodies a relevant problem in immunoscintigraphy with anti-granulocyte antibodies? Nucl Med Commun 1995; 16: 635.
18. 99mTo-labelled human polycional immunoglobulin G. Nucl Med Commun 1990:11: 843-56.
19. Goldenberg DM, Larson SM. Radioimmundetection in Cancer Identification. J Nucl Med 1992; 33: 803-14.
20. Grimmel S, Henrich MM, Reske SN. Entzundungsszintigraphie mit alternativen Tracern (Gallium 67, Nanokolloide, Antigranulozytenantikörper, IIIG). Der Nuklearmediziner 1992; 4: 287-93.
21. Grünwald F, Hotze A. Bnele B, Fuchs A, Keller E, Ott G, Reichmann K. Biersack HJ. Planar and SPECT Imaging with Technetium-99m labelled Antigranulocyte Antibodies in Bone and Soft Tissue Infection. Clin Nucl Med 1993; 18: 587-9.
22. Hertel A, Baum RP, Auerbach B, Herrmann A, Hör G. Klinische Relevanz humaner Anti-Maus-Antikörper (HAMA) in der Immunszintigraphie. Nucl Med 1990; 29: 221-7.
23. 99mTc-Nanokolloid bei orthopädischen Patienten mit Verdacht auf ossäre Infektion. Nue Compact 1988; 18: 176-81.
24. Hotze AL, Briele B, Overbeck B, Kropp J, Gruenwald F. Mekkawy MA, von Smekal A, et al. Technetium-99m-Labelled Anti-Granulocytc Antibodies in Suspected Bone Infections. J Nucl Med 1992; 33: 526-31.
25. Hundeshagen H, Otto HJ, Hememann K, Steinke R. Pethe A. Entzündungsnachweis mit dem Monoklonalen Antigranulocytenantikörper BW 250/183 bei Patienten mit unklarem Fieber. Nucl Med 1993; 32 A55.
26. ICRP Publication 60. 1990 Recommendation of the ICRP. Annals of the ICRP 21. Pergamon Press, 1991.
27. Jackson MH, Millar AM, Dawes J, Bell D. Neutrophil activation during cell separation procedures. Nucl Med Commun 1989; 10: 901-4.
28. Johannson L, Mattson S, Nosslin B. Effective dose equivalent from Radiopharmaceuticals. Eur J Nucl Med 1984; 9: 485-9.
29. 99mTc-MAK-Knochenmarksszintigraphie und sondengezielte Punktion bei aplastischer Anämie. Nucl Med 1992; 31; 202-4.
30. Joseph K, Höffken H, Bosslet K, Schorlemmei HU. Imaging of inflammation with granulocytes labelled in vivo. Nucl Med Commun 1988; 9: 763-9.
31. Keeling DH. Clinical emergencies in the Nuclear Medicine Department. Nucl Med Commun 1988; 9: 259-61.
32. Kroiss A, Kolbl C, Tuchmann A. Auinger C, Weidlich G, Weiss W, Neumayr A. Immunszintigraphie (IS) bei entzündlichen Erkrankungen mit TC-99m-MAK BW 250/183. Acta Medica Austriaca 1989; 16: 11-6.
33. Kroiss A, Bock F, Perneczky G, Auinger Ch, Weidlich G. Kleinpeter G, Brenner H. Immunszintigraphie zur Aufdeckung von Entzündungsherden bei Knochen- und Gelenks-erkrankungen. Wien Klin Wochenschr 1990; 102: 713-7.
34. 99mTc-Antigranulocyte Antibodies. Nucl Med 1989; Suppl 25; 110-3.
35. Lind P, Langsteger W, Költring P, Dimai HP, Passl R. Eber O. Immunoscintigraphy of Inflammatory Processes with a Technetium99m-labelled Monoclonal Antigranulocyte Antibody (MAb BW 250/183). J Nucl Med 1990; 31: 417-23.
36. Lind P, Hausmann B, Költring P, Passl R. Ebert O. Anti Granulocyte Immunoscintigraphy (MAB BW 250/183): Clinical Experience after single and repeated Application JH of intact Murine IgG 1. Nucl Med 1992; Suppl 28: 299-302.
37. Locher JT, Seybold K, Andres RY, et al. Imaging of inflammatory lesions after injection of radioiodinated monoclonal antigranulocyte antibodies. Nucl Med Commun 1986; 7: 659-70.
38. Mahida YR, Perkins AC, Frier M, Wastie ML, Hawkey CJ. Monoclonal Antigranulocyte Antibody imaging in Inflammatory bowel disease: A Preliminary Report. Nucl Med Commun 1992; 13: 330-5.
39. 99mTc-markierter Anti-CEA-Antikörper gegen Granulozyten nach intra-venöser Applikation. Nucl Med 1990; 29: 19-23.
40. McAfee JG, Thakur ML. Survey of radioactive agents for in vitro labelling of phagocytic leucocytes. I. Soluble agents. J Nucl Med 1976; 17: 480-4.
41. McAfee JG. Editorial: What is the best Method for Imaging Focal Infections? J Nucl Med 1990; 31: 413-6.
42. Meller J. Munz DL, Ivancevic V, Djomotschko J, Emrich D. Immun-Entzündungsszintigraphie bei Fieber unklarer Genese (FUG). Nucl Med 1994; 33: A46.
43. Mountford PJ, Nunan TO. Radiation risk and ethical consent. Nucl Med Commun 1995; 16: 1-3.
44. Munz DL, Sandrock D. Comparison of Immunoscintigraphy and colloid scintigraphy of bone marrow. The Lancet 1990; 336: 258-9.
45. Munz DL, Morguet AJ, Sandrock D, Heim A Sold G, Figulla HR, Kreuzer H, Emrich D. Radioimmunoimaging of subacute infective endocarditis using a technetium-99m monoclonal granulocyte-specific antibody. Eur J Nucl Med 1991; 18: 977-80.
46. 99mTc-Anti-Granulozyten-Antikörper (BW 250/183) zum Nachweis der Appendizitis. Nucl Med 1992; 31: 24-8.
47. Pastl K, Maschek W. Höpfl S, Böhler N. Dienstl E, Syré G. Indikationen zur Immunszintigraphie in der Orthopädie und deren Deutung. Wiener Med Wochenschr 1990; 5: 140-6.
48. 111Tc. Nucl Med Commun 1993; 14: 766-74.
49. Perkins AC, Pimm MV, Durant LG. HAMA - a serious problem for Immimoscintigraphy? Eur J Nucl Med 1988; 14: C8.
50. 99mTc-hexamethylpropyleneamine-oxine for labelling leucocytes and imaging inflammation. Lancet 1986; ii: 946-9.
51. Pimm MV, Perkins AC, Gribben SJ, Markham AJ. Mouse-specific antibody response to a monoclonal antibody during repeated immunoscintigraphy investigations: comparison of antibody titres and imaging studies in a rat model. Eur J Nucl Med 1990; 17: 216-22.
52. Radiopharmaceuticals. Commission of the European Communities. Note for Guidance III/3936/89.
53. Radiopharmaceuticals. Commission of the European Communities. Note for Guidance 111/3487/89.
54. Reiners C. Die Strahlenexposition in der nuklearmedizinischen Diagnostik: Risikovergleich auf der Basis effektiver Dosen. Nucl Med 1993; 32: 47-51.
55. Reske SN, Karstens JH, Gloeckner W, Steinsträßer A. Schwarz A, Ammon J. Radioimmunoimaging for diagnosis of Bone Marrow involvement in Breast Cancer and Malignant Lymphoma. The Lancet, February 11, 1989: 299-301.
56. Reske SN, Buell U. Reduced Technetium 99m labelled NCA-95/CEA-Antibody uptake in Liver due to gentle Antibody reconstruction. Eur J Nucl Med 1990; 17: 38-41.
57. Reske SN, Karstens JH, Henrich MM, Sohn M, Glöckner W, Jaske G, Bull U. Nachweis des Skelettbefalls maligner Erkrankungen durch Immunszintigraphie des Knochenmarks. Nucl Med 1993; 32: 111-9.
58. Reuland P, Winker KH, Heuchert T, Ruck P, Müller-Schauenburg W, Weller S, Feine U. Detection of Infection in Postoperative Orthopedic Patients with Technetium-99-label-led Monoclonal Antibody against Granulocytes. J Nucl Med 1991; 32: 2209-14.
59. Rieker O, Grünwald F, Layer G. Kurbacher M, Holze A, Menzel C, Biersack H. Disseminated Bone Marrow Metastases from Primary Breast Cancer. Detection and Follow-up by Radioimmune Bone Marrow Scintigraphy. J Nucl Med 1994; 35: 1485-7.
60. Roedler HD, Lecel U, Moser EA. Strahlenexposition des Patienten bei der Radioimmunszintigraphie. Der Nuklearmediziner 1987; 10: 289-92.
61. Schauwecker DS, Burt TW, Park HM, et al. Clinical Comparison of Indium-111 Acetylacetone and Indium-111 Tropolone Granulocytcs. J Nucl Med 1986; 27: 1675-9..
62. Schauwecker DS, Burt RW. Park HM, et al. Comparison of Purified Indium-111 Granulocytes and Indium-111 Mixed Leukocytes for Imaging of Infections. J Nucl Med 1988; 29: 23-5.
63. Scheidler J. Leinsinger G, Phahler M, Kirsch CM. Diagnosis of Osteomyelitis: Accuracy and Limitations of Antigranulocyte Antibodys Imaging Compared to Three-Phase Bone Scan. Clin Nucl Med 1994; 19: 731-7.
64. Sciuk J, Puskás C, Greitemann B, Schober O. White blood cell Scintigraphy with Monoclonal Antibodies in the Study of the infected Endoprosthesis. Eur J Nucl Med 1992; 19: 497-502.
65. Sciuk J, Brandau W, Vollet B, Stücker R. Erlenrnann R, Bartenstein P, Peters PE, Schober O. Comparison of technetium 99m polyclonal human immunoglobin and technetium 99m monoclonal antibodies for imaging chronic osteomyelitis. First clinical results. Eur J Nucl Med 1991; 18: 401-7.
66. Segarra I, Roca M, Baliellas C, Vilar L, Ricart Y, Mora J, Puchal R. Martin-Comin J. Granulocyte-specific monoclonal antibody technetium-99m-BW 250/183 and indmm111oxine-labelled leucocyte scintigraphy in inflammatory bowel disease. Eur J Nucl Med 1991; 18: 715-9.
67. Steinsträßer A, Berberich R, Kuhlmann L, Zabori S. Schwarz A. Bindung des monoklonalen Antikörpers BW 250/183 an menschliche Granulozyten. Nucl Med 1992; 31: 57-63.
68. Steinsträßer A, Oberhausen E. Anti-CEA labelling kit BW 431/26 - Results of the European multicenter trial. Nucl Med 1995; 34: 232-42.
69. Thakur ML, Segal AW, Louis L, et al. Indium-111 labelled cellular blood components. Mechanism of labelling and intracellular location in human neutrophils. J Nucl Med 1977; 18: 1022-6.
70. Thompson JA, Grunert F, Zimmermann W. Carcinoembryonic Antigen Gene Family: Molecular Biology and Clinical Perspectives. J Clin Lab Analysis 1991; 5: 344-66.
71. Thiele G. Handlexikon der Medizin. Bd. A - K. München-Wien-Baltimore: Urban & Schwarzenberg 1980: S. 1168.
72. Torres G, Berna L, Carrio I, Estorch M, Diaz C, Ferrerons J. Antigranuiocyte Bone Marrow Scans in Paget's Disease. Clin Nucl Med 1994; 19: 671-4.