Skin ultrastructure after calcipotriol treatment: A transmission electron microscopic and freeze-fracture study on psoriatic patients

Acta Dermato-Venereologica

Volumn 76, Issue 3, 1996, Pages 186-189

  Cavicchini, Stefano ^a   Brezzi, Andrea ^a   Gasparini, Giovanni ^a   Caputo, Ruggero ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

dilatation of dermal capillaries; fine intercellular granular material; multilayering of basal lamina

Indexed keywords

CALCIPOTRIOL;

ARTICLE; BASEMENT MEMBRANE; CELL JUNCTION; DESMOSOME; DRUG EFFECT; ELECTRON MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MICROVASCULATURE; PRIORITY JOURNAL; PSORIASIS; SKIN; STRATUM CORNEUM; ULTRASTRUCTURE;

ADULT; AGED; BIOPSY; CALCITRIOL; DERMATOLOGIC AGENTS; FREEZE FRACTURING; HUMANS; MICROSCOPY, ELECTRON; MIDDLE AGED; PSORIASIS; SKIN; TIME FACTORS;

EID: 0029934606     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Nagy-Vezekenyi C, Zs.-Nagy I. Studies on the ultrastructure of psoriasis and of the "normal" skin psoriatics. Acta Derm Venereol (Stockh) 1971; 51: 435-443.
2. Braun-Falco O, Christophers E. Structural aspects of initial psoriatic lesions. Arch Derm Forsch 1974; 251: 95-110.
3. Kamino-Kamino H, Gomez-Estrella S, Tsutsumi V, Hojyo-Tomoka MT, Dominquez-Soto L. Light and electron microscopy studies in psoriasis before and after treatment with retinoids. In: Orfanos CE., et al., eds. Retinoids. Berlin: Springer-Verlag, 1981: 457-466.
4. Orfanos CE, Runne U. Tissue changes in psoriatic plaques after oral administration of retinoid. Dermatologica 1978; 157 (Suppl 1): 19-25.
5. Bruschetta D, Magaudda L, Mondello MR, Santoro G, Vaccaro M, Califano L, et al. Structural and ultrastructural changes of the psoriatic epidermis following cyclosporine treatment. G Ital Dermatol Venereol 1992; 127: 87-93.
6. Braverman IM, Sibley J. The response of psoriatic epidermis and microvessels to treatment with topical steroids and oral methotrexate. J Invest Dermatol 1985; 85: 584-586.
7. Braun-Falco O. Dynamics of growth and regression in psoriatic lesions: alterations in the skin from normal into a psoriatic lesion and during regression of psoriatic lesions. In: Farber EM, Cox AJ, eds. Psoriasis. Proceedings of the International symposium, Stanford University. Stanford: Stanford Univ Press, 1971: 215-237.
8. Cunliffe WJ, Berth-Jones J, Claudy A, Fairiss G, Goldin D, Gratton D, et al. Comparative study of calcipotriol (MC903) ointment and betamethasone 17-valerate ointment in patients with psoriasis vulgaris. J Am Acad Dermatol 1992; 26: 736-743.
9. Kragballe K. Calcipotriol (MC 903), a novel vitamin D3 analogue stimulates the differentiation and inhibits proliferation of cultured human keratinocytes. Arch Dermatol Res 1990; 282: 164-167.
10. Mallett RB, Coulson IH, Purkis PE, Leigh IM, Holden CA. An immunohistochemical analysis of the changes in the immune infiltrate and keratin expression in psoriasis treated with calcipotriol compared with betamethasone ointment. Br J Dermatol 1990; 123: 837 (abstract).
11. Moor H, Muhlethalerk K, Waldner H, Frey-Wyssling A. A new freezing ultramicrotome. J Biophys Biochem Cytol 1961; 10: 1-11.
12. Kanerva L, Niemi KM, Lauharanta J, Juvakoski T, Lassus A. Electron microscopic characterization of the mucus-like material of the epidermis before and after retinoid and retinoid PUVA (RePUVA) treatment of psoriasis. In: Orfanos CE, et al., eds. Retinoids. Berlin: Springer-Verlag, 1981: 467-472.
13. Muller K, Svenson M, Bendtzen K. 1alpha, 25-dihydroxy-vitamin D3 and a novel vitamin D analogue MC903 are potent inhibitors of human interleukin 1 in vitro. Immunol Lett 1988; 17: 371-376.