Effect of nitro-L-arginine on blood flow, oxygenation and the activity of hypoxic cell cytotoxins in murine tumours

British Journal of Cancer

Volumn 74, Issue SUPPL. XXVII, 1996, Pages

  Horsman, M R ^a   Chaplin, D J ^b   Hill, S A ^b   Arnold, S ^b   Collingridge, D ^b   Radacic, M ^a   Wood, P J ^c   Overgaard, J ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b MOUNT VERNON HOSPITAL   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Eppendorf oxygen electrode; Hyperthermia; Laser Doppler flowmetry; Nitro L arginine; RB6145

Indexed keywords

1 (2 BROMOETHYLAMINO) 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; ARGININE DERIVATIVE; CYTOTOXIC AGENT; CYTOTOXIN; ANTINEOPLASTIC AGENT; N(G) NITROARGININE; NITROIMIDAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BREAST CARCINOMA; CANCER TRANSPLANTATION; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HYPERTHERMIC THERAPY; HYPOXIC CELL; INTRAVENOUS DRUG ADMINISTRATION; LASER DOPPLER FLOWMETRY; MOUSE; NONHUMAN; OXYGEN ELECTRODE; OXYGEN TENSION; OXYGENATION; PRIORITY JOURNAL; TUMOR BLOOD FLOW; ANIMAL; ARTICLE; BLOOD FLOW; C3H MOUSE; CBA MOUSE; CELL HYPOXIA; DRUG EFFECT; EXPERIMENTAL NEOPLASM; METABOLISM; SARCOMA; VASCULARIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL HYPOXIA; FEMALE; HYPERTHERMIA, INDUCED; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C3H; MICE, INBRED CBA; NITROARGININE; NITROIMIDAZOLES; REGIONAL BLOOD FLOW; SARCOMA, EXPERIMENTAL;

EID: 0029934551     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (20)

1. ANDRADE SP, HART IR AND PIPER PJ. (1992). Inhibitors of nitric oxide synthase selectively reduce flow in tumor-associated neovasculature. Br. J. Pharmacol., 107, 1092-1095.
2. BREMNER JCM, STRATFORD IJ, BOWLER J AND ADAMS GE. (1990). Bioreductive drugs and the selective induction of tumour hypoxia. Br. J. Cancer, 61, 717-721.
3. CHAPLIN DJ AND ACKER B. (1987). The effect of hydralazine on the tumor cytotoxicity of the hypoxic cell cytotoxin RSU-1069: evidence for therapeutic gain. Int. J. Radiat. Oncol. Biol. Phys., 13, 579-585.
4. DENEKAMP J, HILL SA AND HOBSON B. (1983). Vascular occlusion and tumour cell death. Eur. J. Cancer Clin. Oncol., 19, 271-275.
5. DWORKIN MJ, CARNOCHAN P AND ALLEN-MERSH TG. (1995). Nitric oxide inhibition sustains vasopressin-induced vasoconstriction. Br. J. Cancer, 71, 942-944.
6. GERWECK LE, NYGAARD TG AND BURLETT M. (1979). Response of cells to hyperthermia under acute and chronic hypoxic conditions. Cancer Res., 39, 966-972.
7. HILL SA AND CHAPLIN DJ. (1995). The effect of nicotinamide on microregional blood flow within tumours assessed using laser doppler probes. Acta Oncol., 34, 401-404.
8. HILL SA AND DENEKAMP J. (1978). The effect of vascular occlusion on the thermal sensitization of a mouse tumour. Br. J. Radiol., 51, 997-1002.
9. HORSMAN MR, CHRISTENSEN KL AND OVERGAARD J. (1989). Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo. Int. J. Hyperther., 5, 123-136.
10. HORSMAN MR, CHRISTENSEN KL AND OVERGAARD J. (1992). Relationship between the hydralazine-induced changes in murine tumour blood supply and mouse blood pressure. Int. J. Radiat. Oncol. Biol. Phys., 22, 455-458.
11. 2-histography. Int. J. Radiat. Oncol. Biol. Phys., 19, 953-961.
12. KALMUS J, OKUNIEFF P AND VAUPEL P. (1990). Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors. Cancer Res., 50, 15-19.
13. MONCADA S, PALMER RMJ AND HIGGS EA. (1991). Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-141.
14. OVERGAARD J. (1980). Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding normal tissue in vivo. Int. J. Radiat. Oncol. Biol. Phys., 6, 1507-1517.
15. OVERGAARD J AND BICHEL P. (1977). The influence of hypoxia and acidity on the hyperthermic response of malignant cells in vitro. Radiology, 123, 511-514.
16. OVERGAARD J AND NIELSEN OS. (1980). The role of tissue environmental factors on the kinetics and morphology of tumor cells exposed to hyperthermia. Ann. NY. Acad. Sci., 335, 254-280.
17. SUIT HD. (1975). Hyperthermia in the treatment of tumours. In Proceedings of the International Symposium on Cancer Therapy by Hyperthermia and Radiation, Washington, 28-30 April. pp. 107-114 (American College of Radiology).
18. TOZER GM, PRISE VE AND BELL KM. (1995). The influence of nitric oxide on tumour vascular tone. Acta Oncol., 34, 373-377.
19. G-nitro-L-arginine. Cancer Res., 54, 6458-6463.
20. WOOD PJ, SANSOM JM, STRATFORD JJ, ADAMS GE, SZABO C, THIEMERMANN C AND VANE JR. (1994b). Modification of metabolism in transplantable and spontaneous tumors by the nitric oxide synthase inhibitor nitro-L-arginine. Int. J. Radiat. Oncol. Biol. Phys., 29, 443-447.