IA-2, a transmembrane protein tyrosine phosphatase, is expressed in human lung cancer cell lines with neuroendocrine phenotype

Cancer Research

Volumn 56, Issue 12, 1996, Pages 2742-2744

  Xie, Hong ^a   Notkins, Abner L ^a   Lan, Michael S ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PROTEIN TYROSINE PHOSPHATASE; TUMOR MARKER;

ARTICLE; GENE EXPRESSION; HUMAN; HUMAN CELL; INSULINOMA; LUNG CANCER; NEUROENDOCRINE TUMOR; PHENOTYPE; PRIORITY JOURNAL; TUMOR DIFFERENTIATION;

AUTOANTIGENS; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SMALL CELL; HUMANS; LUNG NEOPLASMS; MEMBRANE PROTEINS; NEOPLASM PROTEINS; PROTEIN-TYROSINE-PHOSPHATASE; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0029934429     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Goto, Y , DeSilva, M G., Toscani, A., Prabhakar, B. S., Notkins, A L , and Lan, M. S. A novel human insulinoma-associated cDNA, IA-1, encodes a protein with zinc-finger DNA-binging motifs J Biol. Chem , 267: 15252-15257, 1992.
2. Lan, M. S., Lu, J , Goto, Y , and Notkins, A L. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Bio , 13: 505-514, 1994.
3. Lan, M. S., Russell, E K , Lu, J., Johnson, B E , and Notkins, A. L. IA-1, a new marker for neuroendocrine differentiation in human lung cancer cell lines. Cancer Res., 53, 4169-4171, 1993
4. Charbonneau, H , and Tonks, N. K. 1002 protein phosphatases? Annu Rev Cell Biol., 8, 463-493, 1992.
5. Lan, M. S., Wasserfall, C., MacLaren, N. K. and Notkins, A L. IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in IDDM Proc. Natl. Acad. Sci. USA, in press, 1996.
6. r tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J. Clin. Invest., 96: 1506-1511, 1995
7. Patel, K., Moore, S. E., Dickson, G., Rossell, R. J , Beverly, P C , Kemshead, J. T , and Walsh, F. S. Neural cell adhesion molecule (NCAM) is the antigen recognized by monoclonal antibodies of similar specificity in small cell lung carcinoma and neuroblastoma. Int. J. Cancer, 44: 573-578, 1989
8. Teitelman, G., Alpert, S., and Hanahan, D Proliferation, senescence, and neoplastic progression of β cells in hyperplastic pancreatic islets Cell, 52: 97-105, 1988.
9. Gazdar, A. F., Helman, L. J., Israel, M. A., Russell, E. K., Linnoila, R. I. Mulshine, J L., Schuller, H. M., and Park, J. G. Expression of neuroendocrine cell markers L-dopa decarboxylase, chromogranin A, and dense core granules in human tumors of endocrine and nonendocrine origin. Cancer Res., 48: 4078-4082, 1988
10. Lee, I , Gould, V. E., Moll, R., Wiedenmann, B., and Franke, W. W. Synaptophysin expressed in bronchopulmonary tract: neuroendocrine cells, neuroepithelial bodies and neuroendocrine neoplasms. Differentiation, 34: 115-125, 1987
11. Simms, E., Gazdar, A. F., Abrams, P. G., and Minna, J. D. Growth of human small cell (oat cell) carcinoma of the lung in serum-free growth factor supplemented medium. Cancer Res., 40: 4356-4363, 1980.
12. Brewer, M., Carney, D. N., Oie, H. K., Gazdar, A. F , and Minna, J. D. Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium Cancer Res., 46, 798-806, 1986.
13. Carney, D. N., Bunn, P. A. J., Gazdar, A. F., Pagan, J. A., and Minna, J. D Selective growth in serum-free hormone-supplemented medium of tumor cells obtained by biopsy from patients with small cell carcinoma of the lung. Proc. Natl. Acad. Sci USA, 78: 3185-3189, 1981.
14. Morstyn, G., Brown, J., Novak, U., Gardner, J., Bishop, J , and Garsoti, M. Heterogeneous cytogenetic abnormalities in small cell lung cancer cell lines. Cancer Res , 47: 3322-3327, 1987.
15. Waters, J. J., Ibson, J. M , Twentyman, P. R., Bleehen, N M., and Rabbins, P H. Cytogenetic abnormalities in human small cell lung carcinoma: cell lines characterized for myc gene amplification. Cancer Genet. Cytogenet., 30: 213-223, 1988.
16. Richardson, G E., and Johnson, B. E. The biology of lung cancer Semin. Oncol., 20: 105-127, 1993.
17. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem., 162: 156-159, 1987.
18. Lu, J., Notkins, A. L , and Lan, M. S. Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phosphatase family. Biochem. Biophys. Res Commun., 204: 930-936, 1994.
19. Passini, N., Larigan, J. D., Genovese, S., Appella, E., Sinigaglia, F., and Rogge, L. The 37/40 kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2. Proc. Natl. Acad Sci. USA, 92, 9412-9416, 1995
20. Kambayashi, Y., Takahashi, K., Bardhan, S., and Inagami, T. Cloning and expression of protein tyrosine phosphatase-like protein derived from a rat pheochromocytoma cell line. Biochem. J., 306: 331-335, 1995.
21. Baekkeskov, S., Aanstoot, H. J., Christgau, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F , Richter-Olesen, H., and Camilli, P. D. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature (Lond.), 347: 151-156, 1990.
22. Rorsman, F., Husebye, E. S., Winqvist, O., Bjork, E., Karlsson, F. A , and Kampe, O. Aromatic L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a β cell autoantigen. Proc. Natl Acad. Sci. USA, 92, 8626-8629, 1995.
23. Alpert, S , Hanahan, D., and Teitelman, G. Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell, 53: 295-308, 1988
24. Teitelman, G Insulin cells of pancreas extend neuntes but do not arise from the ectoderm. Dev. Biol., 142: 368-379, 1990.
25. Graziano, S L , Mazid, R , Newman, N., Tatum, A., Oler, A , Mortimer, J. A , Gullo, J. J , DiFino, S. M., and Scalzo, A. J. The use of neuroendocrine immunoperoxidase markers to predict chemotherapy response in patients with non-small cell lung cancer. J Clin. Oncol., 7: 1398-1406, 1989.
26. Skov, B. G., Sorensen, J. B., Hirsch, F. R., Larsson, L. L. and Hansen, H. H Prognostic impact of histologic demonstration of chromogranin A and neuron specific enolase in pulmonary adenocarcinoma Ann. Oncol., 2: 355-360, 1991.
27. Sundaresan, V , Reeve, J G , Stenning, S., Stewart, S., and Bleehen, N M. Neuroendocrine differentiation and clinical behaviour in non-small cell lung tumors. Br. J. Cancer, 64: 333-338, 1991.
28. Gazdar, A. F., Chick, W. L., Qie, H. K , Sims, H. L , King, G., Weir, G. C., and Lauris, V. Continuous clonal insulin and somatostatin secreting cell lines established from a transplantable rat islet cell tumor. Proc. Natl. Acad. Sci. USA, 77, 3519-3523, 1980.