Asymmetric synthesis. XLI.1 Totally stereoselective synthesis of 1,3-disubstituted tetrahydroisoquinolines via the CN(R,S) method

Tetrahedron Letters

Volumn 37, Issue 25, 1996, Pages 4369-4372

  Gosmann, Grace ^a   Guillaume, Dominique ^a   Husson, Henri Philippe ^a  

^a FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

OXAZOLIDINE DERIVATIVE; OXOACID; PHENYLGLYCINE; TETRAHYDROISOQUINOLINE DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CIS ISOMER; CYCLIZATION; DIASTEREOISOMER; DRUG SYNTHESIS; REDUCTION; STEREOCHEMISTRY; TRANS ISOMER;

EID: 0029934323     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00819-2     Document Type: Article

References (18)

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10. (d) Husson, H.-P.; Royer, J. Advances in the Use of Synthons in Organic Chemistry, A. Dondoni Ed.; JAI Press: London 1995, 2, p. 1-68.
11. 2 for 2 days then saponification.
12. 13C NMR spectroscopy and exhibit satisfactory combustion analyses for C, H, and N.
13. Brossi, A.; Teitel, S. Helv. Chim. Acta 1971, 54, 1564-1571.
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15. 3) δ 152.9, 147.5, 146.7, 140.8, 139.3, 139.1, 136.6, 130.6, 129.2, 128.4, 128.2, 127.9, 127.7, 126.2, 110.8, 104.7, 68.0, 62.3, 60.9, 60.7, 60.5, 56.0, 55.8, 44.5, 32.2.
16. 5d Marazano et al. have recently described the reaction of a substrate closely related to 4 with Grignard reagents: Barbier D. Ph.D. Dissertation, Université Paris-Sud, Orsay 1995.
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