Defective natural killer cell activity in b-cell chronic lymphocytic leukaemia is associated with impaired release of natural killer cytotoxic factor(s) but not of tumour necrosis factor-α

Acta Haematologica

Volumn 96, Issue 1, 1996, Pages 16-23

  Katrinakis, George ^a   Kyriakou, Despina ^a   Papadaki, Helene ^a   Kalokyri, Irene ^a   Markidou, Fotini ^a   Eliopoulos, George D ^a  

^a UNIVERSITY OF CRETE   (Greece)

Author keywords

Chronic lymphocytic leukaemia; Mitogen induced cellular cytotoxicity; Natural killer cell activity; Natural killer cytotoxic factor; Tumour necrosis factor

Indexed keywords

CD16 ANTIGEN; CD3 ANTIGEN; CD57 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC FACTOR; GRANZYME; PERFORIN; PHYTOHEMAGGLUTININ; RECOMBINANT ALPHA INTERFERON; RECOMBINANT INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CELL MEDIATED CYTOTOXICITY; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; TUMOR CELL;

ADULT; AGED; AGED, 80 AND OVER; CELL SEPARATION; CHI-SQUARE DISTRIBUTION; CYTOTOXICITY TESTS, IMMUNOLOGIC; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HUMANS; IMMUNOPHENOTYPING; KILLER CELLS, NATURAL; LEUKEMIA, B-CELL, CHRONIC; MALE; MIDDLE AGED; PROTEINS; SOLUBILITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029934177     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000203709     Document Type: Article

References (28)

1. Gale RP, Foon KA: Chronic lymphocytic leukemia. Recent advances in biology and treatment. Ann Intern Med 1985;103:101-120.
2. Aiscnbcrg AC, Block KJ: Immunoglobulins on the surface of neoplastic lymphocytes. N Engl J Med 1972;287:272-276.
3. Foon KA, Gale RP: Chronic lymphocytic leukaemia and related diseases; in Hoflbrand AV (ed): Recent Advances in Haematology. London, Churchill Livingstone, 1988, pp 179-209.
4. Platsoucas CD, Fernandez G, Gupta SL. Kem-pin S, Clarkson B, Good RA, Gupta S: Defective spontaneous and antibody-dependent cytotoxicity mediated by E-rosette-positive and E-rosette-negative cells in untreated patients with chronic lymphocytic leukemia: Augmentation by in vitro treatment with interferon. J Immunol 1980;125:1216-1223.
5. Ziegler HW, Kay NE, Zarling JM: Deficiency of natural killer cell activity in patients with chronic lymphocytic leukaemia. Int J Cancer 1981;27:321-327.
6. Trinchicri G: Biology of natural killer cells. Adv Immunol 1989;47:187-376.
7. Timonen T. Saksela E: Isolation of human natural killer cells by density gradient centrifugation. J Immunol Methods 1980;36:285-291.
8. Zarling JM, Clouse KA. Biddison W, Kung P: Phenotypes of human natural killer cell population detected with monoclonal antibodies. J Immunol 1981;127:2575-2580.
9. Lanier LL, Le AM, Phillips J, Warner N, Babcock G: Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens. J Immunol 1983;131:1789-1796.
10. Robertson M, Ritz J: Biology and clinical relevance of human natural killer cells. Blood 1990;76:2421-2438.
11. Wright S, Bonavida B: Studies on the mechanism of natural killer (NK) cell-mediated cytotoxicity (CMC). I. Release of cytotoxic factors specific for NK-scnsitive target cells (NKCF) during co-culture of NK and target cells. J Immunol 1982;129:433-439.
12. Kawasaki A, Shinkai Y, Kuwana Y, Furuya A, Iigo Y. Hanai N. Itoh S, Yagita H, Okumura K: Perforin, a pore-forming protein detectable by monoclonal antibodies, is a functional marker for killer cells. Int Immunol 1990;2:677-682.
13. Hayes MP, Berrebi GA, Henkart PA: Induction of target cell DNA release by the cytotoxic T lymphocyte granule proteasc granzyme A. J Exp Med 1989;170:933-940.
14. Wright S, Bonavida B: Studies on the mechanism of natural killer (NK) cell-mediated cytotoxicity (CMC). VII. Functional comparison of human natural killer cytotoxic factors with recombinant lymphotoxic and tumor necrosis factor. J Immunol 1987; 138:1791-1798.
15. Ucker DS: Cytotoxic T-lymphocytcs and glucocorticoids activate an endogenous suicide process in target cells. Nature 1987;327:62-64.
16. Foa R, Fierro M-T, Lusso T. Raspadori D, Fer-rando MI, Matera L, Malavasi F, Lauria F: Reduced natural killer T-cells in B-cell chronic lymphocytic leukaemia identified by three monoclonal antibodies: Leull, A10, AB8.28. Br J Haematol 1986;62:151-154.
17. Kay NE, Starling JM: Impaired natural killer activity in patients with chronic lymphocytic leukemia is associated with a deficiency of azurophilic cytoplasmic granules in putative NK cells. Blood 1984;63:305-309.
18. Eliopoulos GD, Vaiopoulos G, Kyriakou D, Papadaki H, Katrinakis G, Alexandrakis M: Impaired release of natural killer cytotoxic fac-tor(s) by peripheral blood lymphocytes in patients with chronic LGL-proliferative disease. Hacmatologica 1993;78:219-224.
19. Rodcr JC, Argov S, Klein M. Petersson C, Kiessling R, Anderson K, Hansson M: Target-effector cell interaction in the natural killer cell system. V. Energy requirements, membrane integrity, and the possible involvement of lysosomal enzymes. Immunology 1980:40:107-116.
20. Katrinakis G, Kyriakou D, Papadaki H, Sakel-lariou D, Foudoulakis A, Eliopoulos GD: Evidence for involvement of activated CD8V HLA-DR* cells in the pathogenesis of neutropenia in patients with B-cell chronic lymphocytic leukaemia. Eur J Haematol 1995;55:53-41.
21. Apostolopoulos A, Symeonidis A, Zoumbos N: Prognostic significance of immune function parameters in patients with chronic lymphocytic leukaemia. Eur J Haematol 1990;44:39-44.
22. Trentin L, Zambello R, Agostini C, Anbrosctti A, Chisesi T, Raimondi R, Bulian P, Pizzolo G, Semenzato G: Mechanisms accounting for the defective natural killer activity in patients with hairy cell leukemia. Blood 1990;75:1525-1530.
23. Pedersen BK, Oxholm P: Impaired release of natural killer cytotoxic factor in patients with primary Sjogren’s syndrome. Clin Exp Immunol 1988;72:299-302.
24. Eliopoulos GD, Coulocheri S, Eliopoulos AG, Katrinakis G, Karkavitsas N, Kyriakou D, Vaiopoulos G, Foudoulakis A: Mechanisms accounting for the impaired natural killer cell activity in refractory anaemia with excess of blasts. EurJ Haematol 1992;48:237-243.
25. Zambello R, Trentin L, Agostini C, Chisesi T, Vespignani M, Pizzolo G, Pandolfi F, Ensoli F, Semenzato G: Release of natural killer cytotoxic factor in patients with lymphoprolifera-tive disease of granular lymphocytes. Leuk Res 1989:13:315-322.
26. Eliopoulos GD, Vaiopoulos G, Eliopoulos AG, Kyriakou D, Katrinakis G, Alexandrakis M: Patients with chronic LGL-proliferative disease express high mitogen-induced cellular cytotoxicity which may be partially mediated by humoral cytolytic molecules. Hacmatologia 1993;25:215-222.
27. Fernandez LA, MacSween J, Langley GR: Impaired T cell responses in chronic lymphocytic leukemia: Lack of suppressor cell effect. Clin Immunol Immunopathol 1981;18:168-174.
28. Reiter Z, Rubinstein M: Interleukin-la and tumor necrosis factor protect cells against natural killer cell-mcdiatcd cytotoxicity and natural killer cytotoxic factor. Cell Immunol 1990; 125: 326-336.