Chronic dexamethasone treatment and its effects on sensory neuropeptides, pulpal injury reactions and reparative dentin

Brain Research

Volumn 723, Issue 1-2, 1996, Pages 125-134

  Ferrari, A M ^a   Byers, M R ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

calcitonin gene related peptide; inflammation; pain; reparative dentin; sensory nerve sprouting; steroid; substance P

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; DEXAMETHASONE; NEUROPEPTIDE; SUBSTANCE P;

ADOLESCENT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; TOOTH INJURY;

EID: 0029934079     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00231-4     Document Type: Article

References (46)

1. Ahlberg, K., Dose-dependent inhibition of sensory nerve activity in the feline dental pulp by anti-inflammatory drugs, Acta Physiol. Scand., 102 (1978) 434-440.
2. Antila, R. and Pohto, P., In vitro studies on the prostaglandin system in tooth pulp, Proc. Finn. Dent. Soc., 80 (1984) 245-252.
3. Arai, H., Neurohistological study on responses of nerve fibers to pulpitis in human teeth, Jpn. J. Conserv. Dent., 34 (1991) 1631-1646.
4. Baxendale, B.R., Vater, M. and Lavery, K.M., Dexamethasone reduces pain and swelling following extraction of third molar teeth, Anaesthesia, 48 (1993) 961-964.
5. Byers, M.R., Neuropeptide immunoreactivity in dental sensory nerves: variations related to primary odontoblast function and survival, Quintessence J., (1996) accepted for publication.
6. Byers, M.R. and Ferrari, A.M., Chronic dexamethasone reduces pulpal inflammation and neuropeptides but not reparative dentin, J. Dent. Res., 75 (Spec. Iss.) (1996) 356.
7. Byers, M.R. and Taylor, P.E., Effect of sensory denervation on the response of rat molar pulp to exposure injury, J. Dent. Res., 72 (1993) 613-618.
8. Byers, M.R., Taylor, P.E., Khayat, B.G. and Kimberly, C.L., Effects of injury and inflammation on pulpal and periapical nerves, J. Endodont., 16 (1990) 78-84.
9. Byers, M.R., Wheeler, E.F. and Bothwell, M., Altered expression of NGF and p75 NGF-receptor by fibroblasts of injured teeth precedes sensory nerve sprouting, Growth Factors, 6 (1992) 41-52.
10. Chance, K.B., Lin, L. and Skribner, J.E., Corticosteroid use in acute apical periodontitis: a review with clinical applications, Clin. Preventive Dent., 10 (1988) 7-10.
11. Dalsgaard, C.-J., Hultgardh-Nilsson, A., Haegerstrand, A. and Nilsson, J., Neuropeptides as growth factors. Possible roles in human diseases, Regul. Pept., 25 (1989) 1-9.
12. Fauci, A.S., Dale, D.C. and Balow, J.E., Glucocorticosteroid therapy: mechanisms of action and clinical considerations, Ann. Int. Med., 84 (1976) 304-315.
13. Foreman, J.C., Neuropeptides and the pathogenesis of allergy, Allergy, 42 (1987) 1-11.
14. Gazelius, B., Edwall, B. and Olgart, L., Vasodilatory effects and coexistence of CGRP and substance P in the sensory nerves of cat dental pulp, Acta Physiol. Scand., 130 (1987) 33-40.
15. Gilman, B., Goodman, L.S. and Gilman, A., The Pharmacological Basis of Therapeutics, 6th edn., Macmillan, New York, 1980, pp. 1470-1496.
16. Hargreaves, K.M., Schmidt, E.A., Mueller, G.P. and Dionne R.A., Dexamethasone alters plasma levels of beta-endorphin and postoperative pain, Clin. Pharmacol. Ther., 42 (1987) 601-607.
17. Hong, D., Byers, M.R. and Oswald, R.J., Dexamethasone treatment reduces sensory neuropeptides and nerve sprouting reactions in injured teeth, Pain, 55 (1983) 171-181.
18. Jacobsen, E.B. and Heyeraas, K.J., Effect of capsaicin and IAN resection on rat dentin formation, J. Dent. Res., 74 (Spec. Iss.) (1995) 408.
19. Kasugai, S., Shibata, S., Susami, T. and Ogura, H., Characterization of a system of mineralized tissue formation by rat dental pulp cells in culture, Arch. Oral Biol., 38 (1993) 769-777.
20. Kimberly, C.L. and Byers M.R., Inflammation of rat molar pulp and periodontium causes increased calcitonin gene-related peptide and axonal sprouting, Anat. Rec., 222 (1988) 289-300.
21. Kjartansson, J. and Dalsgaard, C., Calcitonin gene-related peptide increases survival of musculocutaneous critical flap in the rat, Eur. J. Pharmacol., 142 (1987) 355-358.
22. Langeland, K., Langeland, L.K. and Anderson D.M., Corticosteroids in dentistry, Int. Dent. J., 27 (1977) 217-251.
23. Maeda, T., Iwanaga, T., Fugita, T., Takahashi, Y. and Kobayashi, S., Distribution of nerve fibers immunoreactive to neurofilament protein in rat molars and periodontium. Cell Tiss. Res., 249 (1987) 13-23.
24. Maggi, C.A., The pharmacology of the efferent function of sensory nerves, J. Auton. Pharmacol., 11 (1991) 173-208.
25. Mjor, I.A., Histologic studies of human coronal dentine following the insertion of various materials in experimentally prepared cavities, Arch. Oral Biol., 12 (1967) 441-452.
26. Oguntebi, B.R., Barker, B.F., Anderson, D.M. and Sakamura, J., The effect of indomethacin on experimental dental periapical lesions in rats, J. Endodont., 15 (1989) 117-121.
27. Okiji, T., Morita, I., Surada, I. and Murota, S., Involvement of arachidonic acid metabolites in increases in vascular permeability in experimental design pulpal inflammation in the rat, Arch. Oral Biol., 34 (1989) 523-528.
28. Olgart, L.M., The role of local factors in dentin and pulp in intradental pain mechanisms, J. Dent. Res., 64 (1985) 572-578.
29. Olgart, L.M., Edwall, B. and Gazelius, B., Neurogenic mediators in control of pulpal blood flow, J. Endodont., 15 (1989) 409-412.
30. Oswald, R.J. and Byers, MR., The injury response of pulpal NPY-IR sympathetic fibers differs from that of sensory afferent fibers, Neurosci. Lett., 164 (1993) 190-194.
31. Pernow, B., Role of tachykinins in neurogenic inflammation, J. Immunol., 135 (1985) 812S-815S.
32. Plackova, A., Pathologic changes in the innervation of the dental pulp during carious process, J. Dent. Res., 45 (1966) 62-65.
33. Sato, O., Responses of pulpal nerves to cavity preparation in rat molars. An immunohistochemical study using mouse filament protein (NFP) antiserum, Arch. Histol. Cytol., 52 (1989) 437-4446.
34. Silverman, J.E. and Kruger, L., An interpretation of dental innervation based upon the pattern of calcitonin gene-related peptide (CGRP)-immunoreactive thin sensory axons, Somatosens. Res., (1987) 157-175.
35. Sisk, A. and Bonnington, G.J., Evaluation of methylprednisolone and flurbiprofen for inhibition of the postoperative inflammatory response, Oral Surg., 60 (1985) 137-145.
36. Smith, A.J., Tobias, R.S., Cassidy, N., Plant, C.B., Browne, R.M., Begue-Kirn, C., Ruch, J.V. and Lesot, H., Odontoblast stimulation in ferrets by dentine matrix components, Arch. Oral Biol., 39 (1994) 13-22.
37. Smith, G.D., Seckl, J.R., Sheward, W.J., Bennie, J.G., Carroll, S.M., Dick, H. and Harman, A.J., Effect of adrenalectomy and dexamethasone on neuropeptide content of dorsal root ganglia in the rat, Brain Res., 564 (1991) 27-30.
38. Swift, M.L. and Byers, M.R., Effect of aging on responses of nerve fibers to pulpal inflammation in rat molars analyzed by quantitative immunocytochemistry, Arch. Oral Biol., 37 (1992) 901-912.
39. Taylor, P.E., Byers, M.R. and Redd, P.E., Sprouting of CGRP nerve fibers in response to dentin injury in rat molars, Brain Res., 461 (1988) 371-376.
40. Taylor, P.E. and Byers, M.R., Response of CGRP-immunoreactive nerve fibers to pulpitis and healing in rat molars, Arch. Oral Biol., 35 (1990) 629-638.
41. Tverberg, L.A. and Russo, A.F., Cell-specific glucocorticoid repression of calcitonin/calcitonin gene-related peptide transcription, J. Biol. Chem., 267 (1992) 17567-17573.
42. Wion, D., Houlgatte, P. and Brachet, P., Dexamethasone rapidly reduces the expression of the b-NGF gene in mouse L-929 cells, Exp. Cell Res., 162 (1986) 562-565.
43. Yakovlev, A.G., de Bernardi, M.A., Fabrazzo, M., Brooker, G., Costa, E. and Mocchetti, I., Regulation of nerve growth factor receptor mRNA content by dexamethasone: in vitro and in vivo studies, Neurosci. Lett., 116 (1990) 216-220.
44. Yamaura, Y., Immunohistochemical investigation on the nerve fibers of the dental pulp after cavity preparation, Jpn. J. Conserv. Dent., 30 (1987) 814-838.
45. Yamaura, Y., Yamazaki, M. and Hirai, M., Immunohistochemical investigations on the nerve fibers of carious teeth, J. Dent. Res., 67 (Spec. Iss.) (1988) 134.
46. Zeytin, F.N., Rusk, S. and Leff, S.E., Calcium, dexamethasone and the antiglucocorticoid RU-486 differentially regulate neuropeptide synthesis in a rat C-cell line, Endocrinology, 121 (1987) 361-370.