Low concentrations of carbachol induce oscillations of membrane voltage towards ecl– but not the nernst potential for nonselective cation channels in rat pancreatic acinar cells

Cellular Physiology and Biochemistry

Volumn 6, Issue 1-2, 1996, Pages 123-128

  Zdebik, A ^a   Hug, M J ^a   Greger, R ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Carbachol; Cl conductance; NaCl secretion; Pancreas; Voltage oscillations

Indexed keywords

CARBACHOL; CHLORIDE CHANNEL; ION CHANNEL;

ACINAR CELL; ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CHLORIDE CONDUCTANCE; HORMONAL REGULATION; HYPERPOLARIZATION; ION TRANSPORT; NONHUMAN; OSCILLATION; POTASSIUM TRANSPORT; PRIORITY JOURNAL; RAT; SODIUM EXCRETION;

EID: 0029933961     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000154801     Document Type: Article

References (11)

1. Grcger R, Schlatter E, Wang F, Forrest JNJ: Mechanism of NaCI secretion in rectal gland tubules of spiny dogfish (Squalusacanlhias). III. Effects of stimulation of secretion by cyclic AMP. Pfliigcrs Arch Eur J Physiol 1984;402:376-384.
2. Petersen OH: Stimulus-sccretion coupling: Cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells. J Physiol (Lond) 1992;448:1-51.
3. Robertson MA. Foskelt JK: Na+ transport pathways in secretory acinar cells: Membrane cross-talk mediated by [Cl-]i. Aml Physiol 1994: 267:C146-C156.
4. Zhao H, Muallem S: Na+. K+. and Cl- transport in resting pancreatic acinar cells. J Gen Physiol 1995: 106:1225-1242.
5. Kasai H, Augustine GJ: Cytosolic Ca2+ gradients triggering unidirectional fluid secretion from exocrine pancreas. Nature 1990:348:735-738.
6. Kasai H. Li YX. Miyashita Y: Sub-cellular distribution of Ca2+ release channels underlying Ca2+ waves and oscillations in exocrine pancreas. Cell 1993:74:669-677.
7. Slawik M, Zdebik A, Hug MJ, Kerstan D, Leipziger J, Grcger R: Whole cell conductive properties of rat pancreatic acini. Pflügers Arch Eur J Physiol, in press.
8. Yule DJ, Gallachcr DV: Oscillations of cytosolic calcium in single pancreatic acinar cells stimulated by acetylcholine. FEBS Lett 1988:239: 358-362.
9. Petersen OH. Wakui M: Oscillating intracellular Ca2+ signals evoked by activation of receptors linked to inositol lipid hydrolysis: Mechanism of generation. J Mcmbr Biol 1990:118: 93-105.
10. Hamill OP, Marty A, Ncher E, Sakmann B, Sigworth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugcrs Arch Eur J Physiol 1981:391:85-100.
11. Horn R, Marty A: Muscarinic activation of ionic currents measured by a new whole-cell recording method. J Gen Physiol 1988:92:145-159.