Effect of pH on in vitro potency of amantadine against Plasmodium falciparum

American Journal of Tropical Medicine and Hygiene

Volumn 54, Issue 3, 1996, Pages 232-236

  Evans, Sandra Gail ^a   Havlik, Ivan ^a  

^a UNIVERSITY OF THE WITWATERSRAND MEDICAL SCHOOL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; AMMONIUM CHLORIDE; ANTIMALARIAL AGENT; CHLOROQUINE; MEFLOQUINE; QUININE;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG EFFECT; DRUG POTENCY; DRUG RESISTANCE; DRUG SENSITIVITY; ERYTHROCYTE; IN VITRO STUDY; NONHUMAN; PARASITISM; PH; PLASMODIUM FALCIPARUM;

EID: 0029933587     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1996.54.232     Document Type: Article

References (24)

1. Ginsburg H, Krugliak M, 1992. Quinoline-containing antimalarials -mode of action, drug resistance and its reversal. An update with unresolved puzzles. Biochem Pharmacol 43: 63-70.
2. 3H-chioroquine. Am J Pathol 69: 277-284.
3. Wellems TE, 1992. How chloroquine works. Nature 355: 108-109.
4. Yayon A, Cabantchik ZI, Ginsburg H, 1984. Identification of the acidic compartment of Plasmodium falciparum infected human erythrocytes as the target of the antimalarial drug chloroquine. Eur J Biochem 3: 2695-2700.
5. Evans SG, Havlik I, 1993. Plasmodium falciparum: effects of amantadine, an antiviral, on chloroquine-resistant and -sensitive parasites in vitro and its influence on chloroquine activity. Biochem Pharmacol 45: 1168-1170.
6. Evans SG, Havlik I, 1994. In vitro drug interactions between amantadine and classical antimalarials in Plasmodium falciparum. Trans R Soc Trop Med Hyg 88: 683-686.
7. Freese JA, Sharp BL, Ridl FC, Markus MB, 1988. In vitro cultivation of southern African strains of Plasmodium falciparum and gametocytogenesis. S Afr Med J 73: 720-722.
8. Jensen JB, 1978. Concentration from continuous culture of erythrocytes infected with trophozoites and schizonts of Plasmodium falciparum. Am J Trop Med Hyg 27: 1274-1276.
9. Ginsburg H, Nissani E, Krugliak M, 1989. Alkalinization of the food vacoule of malaria parasites by quinoline drugs and alkylamines is not correlated with their antimalarial activity. Biochem Pharmacol 38: 2645-2654.
10. Desjardins RE, Canfield CJ, Haynes JD, Chulay JD, 1979. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution method. Antimicrob Agents Chemother 16: 710-718.
11. Johnson RG, Carty SE, Scarpa A, 1981. Accumulation of amantadine by isolated chromaffin granules. Biochem Pharmacol 30: 763-769.
12. Geary TG, Divo AD, Jensen JB, Zangwill M, Ginsburg H, 1990. Kinetic modelling of the response of Plasmodium falciparum to chloroquine and its experimental testing in vitro. Biochem Pharmacol 40: 685-691.
13. Yayon A, Cabantchik ZI, Ginsburg H, 1985. Susceptibility of human malaria parasites to chloroquine is pH dependent. Proc Natl Acad Sci USA 82: 2784-2788.
14. 3H]chloroqume by drug-sensitive and -resistant strains of the human malaria parasite Plasmodium falciparum. Biochem Pharmacol 35: 3805-3812.
15. Krugliak M, Ginsburg H, 1991. Studies on the antimalarial mode of action of quinoline-contarning drugs: time-dependence and irreversibility of drug action, and interactions with compounds that alter the function of the parasite's food vacuole. Life Sci 49: 1213-1219.
16. Richman DD, Yazaki P, Hosteller KY, 1981. The intracellular distribution and antiviral activity of amantadine. Virology 112: 81-90.
17. 2 protein: characterization of the amantadine block. J Virol 67: 5585-5594.
18. Weller M, Finiels-Marlier F, Paul SM, 1993. NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons: neuroprotective properties of amantadine and memantine. Brain Res 613: 143-148.
19. Ashcroft FM, Kerr AJ, Gibson JS, Williams BA, 1991. Amantadine and sparteme inhibit ATP-regulated K-currents in the insulin-secreting β-cell line, HIT-T15. Br J Phannacol 104: 579-584.
20. Ginsburg H, Stein WD, 1987. New permeability pathways induced by the malarial parasite in the membrane of its host erythrocyte: potential routes for targeting of drugs into infected cells. Biosci Rep 7: 455-463.
21. Shalmiev G, Ginsburg H, 1993. The susceptibility of the malarial parasite Plasmodium falciparum to quinoline-contaimng drugs is correlated to the lipid composition of the infected erythrocyte membranes. Biochem Pharmacol 46: 365-374.
22. Duff KC, Cudmore AJ, Bradshaw JP, 1993. The location of amantadine hydrochloride and free base within phospholipid multilayers: a neutron and X-ray diffraction study. Biochim Biophys Acta 1145: 49-156.
23. Sherman IW, Greenan JRT, 1984. Altered red cell membrane fluidity during schizogonic development of malarial parasites Plasmodium falciparum and P.lophurae. Trans R Soc Trop Med Hyg 78: 641-644.
24. Mason RP, 1993. Membrane interaction of calcium channel antagonists modulated by cholesterol. Biochem Pharmacol 45: 2173-2183.