Nitric oxide-induced perturbations in a cell culture model of the blood-brain barrier

Journal of Cellular Physiology

Volumn 167, Issue 1, 1996, Pages 89-94

  Hurst, R D ^a,b   Fritz, I B ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC GMP; FREE RADICAL; HEMOGLOBIN; METHYLENE BLUE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PHOTOSENSITIZING AGENT; ROUSSIN BLACK SALT; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL MODEL; BLOOD BRAIN BARRIER; CELL CULTURE; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; GLIOMA CELL; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LIGHT EXPOSURE; MEMBRANE PERMEABILITY; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD-BRAIN BARRIER; ELECTRIC IMPEDANCE; ENDOTHELIUM, VASCULAR; GLIOMA; HUMANS; INTERCELLULAR JUNCTIONS; IRON CHELATING AGENTS; IRON COMPOUNDS; NITRIC OXIDE; NITROSO COMPOUNDS; RATS; VASODILATOR AGENTS;

EID: 0029933293     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199604)167:1<89::AID-JCP10>3.0.CO;2-K     Document Type: Article

References (36)

1. Bolanos, J.P., Peuchen, S , Heales, S.J.R., Land, J.M., and Clark, J B. (1994) Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J. Neurochem., 63:910-916.
2. Chandler, C.L., Moore, A.R , Desa, F.M., Howat, D., and Willoughby, D.A. (1988) The local modulation of vascular permeability by endothelial cell derived products. J. Pharm. Pharmacol., 40:745-746.
3. Dawson, T.M., and Snyder, S.H. (1994) Gases as biological messengers: Nitric oxide and carbon monoxide in the brain. J. Neurosci., 14:5147-5159.
4. Durieu-Trautmann, O., Federici, C., Creminon, C., Foignant-Chaverot, N., Roux, F., Claire, M., Strosberg, A D., and Couraud, P.O. (1993) Nitric oxide and endothelin secretion by brain microvessel endothelial cells: Regulation by cyclic nucleotides. J. Cell. Physiol., 155:104-111.
5. Flitney, F.W., Megson, I.L., Flitney, D.E., and Butler, A.R. (1992) Iron-sulphur cluster nitrosyls, a novel class of nitric oxide generator: Mechanism of vasodilator action on rat isolated tail artery. Br. J. Pharmacol., 107:842-848.
6. Furchgott, R.F. (1991) Endothelium-dependent relaxation, endothelium-derived relaxing factor and photorelaxation of blood vessels. Semin. Perinatol., 15:11-15.
7. Furchgott, R.F., and Zawadski, J.V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288:373-376.
8. Glauser, M.P., Zanetti, G., Baumgartner, J.D., and Cohen, J. (1991) Septic shock: Pathogenesis. Lancet, 338:732-739.
9. Gross, S.S., Jaffe, E.A., Levi, R., and Kilbourn, R.G. (1991) Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopepterin-dependent, calmodulin-independent and inhibited by arginine analogs with rank-order of potency characteristic of activated macrophages. Biochem. Biophys. Res. Commun., 178:823-829.
10. Gruetter, C.A., Barry, B.K., McNamara, D.B., Gruetter, D.Y., Kadowitz, P.J., and Ignarro, L.J. (1979) Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosamine. J. Cyclic Nucleotide Protein Phosphor. Res., 5:211-222.
11. Hibbs, J.B., Taintor, R.R., Vavrin, Z., and Rachlin, E.M. (1988) Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochem. Biophys. Res. Commun., 157:87-94.
12. Hurst, R.D., and Fritz, I.B. (1996) Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier. J. Cell. Physiol., 167:81-88.
13. Ignarro, L.J. (1990) Biosynthesis and metabolism of endothelium derived nitric oxide. Annu. Rev. Pharmacol. Toxiol., 30:535-560.
14. Ishii, K., Chang, B., Kerwin, J.F., Huang, Z.J., and Murad, F. (1990) N-nitro-L-arginine: A potent inhibitor of endothelium-derived relaxing factor formation. Eur. J. Pharmacol., 76:219-223.
15. Joo, F., Temesvai, P., and Dux, E. (1983) Regulation of the macromolecular transport in the brain microvessels: The role of cyclic GMP. Brain Res., 278:165-174.
16. Knowles, G., and Moncada, S. (1992) Nitric oxide as a signal in blood vessels. TIBS, 17:399-402.
17. Kreye, V.A. (1980) Sodium nitroprusside. In: Pharmacology of Antihypertensive Drugs. A. Scribine, ed. Raven Press, New York, pp. 373-396.
18. Kronke, K.D., Brenner, H.H., Rodriguez, M.C., Etzkorn, K., Noack, E.A., Kolb, H., and Kolb-Bachofen, V. (1993) Pancreatic islet cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide. Biochem. Biophys. Acta, 1182:221-229.
19. Matsunaga, K., and Furchgott, R.F. (1989) Interactions of light and sodium nitrite in producing relaxation of rabbit aorta. J. Pharmacol. Exp. Ther., 248:687-695.
20. Matthews, E.K., Seaton, E.D., Forsyth, M.J., and Humphrey, P P.A. (1994) Photon pharmacology of an iron-sulphur cluster nitrosyl compound acting on smooth muscle. Br. J. Pharmacol., 113:87-94.
21. Mayer, B., Brunner, F., and Schmidt, K. (1993) Inhibition of nitric oxide synthesis by methylene blue. Biochem. Pharmacol., 45:367-374.
22. Moncada, S., Palmer, R.M.J., and Higgs, E.A. (1991) Nitric oxide: Physiology, pathophysiology and pharmacology. Pharm. Rev., 43:109-142.
23. Murphy, S., Simmons, M.L., Agullo, L., Garcia, A., Feinstein, D.L., Galea, E., Reis, D.J., Minc-Galomb, D., and Schwartz, J.P. (1993) Synthesis of nitric oxide in CNS glial cells. TINS, 16:323-328.
24. O'Connor, K.J., and Moncada, S. (1991) Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells. Biochim. Biophys. Acta, 107:227-231.
25. Palmer, R.M.J., Bridge, L., Foxwell, N.I.A., and Moncada, S. (1992) The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticords. Br. J. Pharmacol., 105:575-580.
26. Radomski, M.W., Palmer, R.M.J., and Moncada, S. (1990) Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad Sci. U.S.A., 87:10043-10047.
27. Rubin, L.L., Hall, D.E., Porter, S., Barbu, K., Cannon, C., Horner, H.C., Janatpour, M., Liaw, C.W., Manning, K., Morales, J., Tanner, L.I., Tomaselli, K.J., and Bard, F. (1991) A cell culture model of the blood-brain barrier. J. Cell. Biol., 115:1725-1735.
28. Schulz, R., and Triggle, C.R. (1994) Role of NO in vascular smooth muscle and cardiac muscle function. TIPS, 15:255-259.
29. Shasby, D.M., Lind, S.E., Shasby, S.S., Goldsmith, J.C., and Hunninghake, G.W. (1985) Reversible oxidant-induced increases in albumin transfer across cultured endothelium: Alterations in cell shape and calcium homeostasis. Blood, 65:605-614.
30. Simmons, M.L., and Murphy, S. (1992) Induction of nitric oxide synthase in glial cells. J. Neurochem., 59:897-905.
31. Stuehr, D.J., and Nathan, C.F. (1989) Nitric oxide. A macrophage product responsible for cytostasis in tumor target cells. J. Exp. Med., 163:1543-1555.
32. Tracey, K.J., and Lowry, S.F. (1990) The role of cytokine mediators in septic shock. Adv. Surg., 23:21-56.
33. Vanin, A.F. (1991) Endothelium-derived relaxing factor is a nitrosyl iron complex with thiol ligands. FEBS Lett., 289:1-3.
34. Yuan, Y., Granger, H.J., Zawieja, D.C., Defily, D.V., and Chilian, W.M. (1993) Histamine increases vescular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade. Am. J. Physiol., 264:H1734-H1739.
35. Zhang, J., Dawson, V.L., Dawson, T.M., and Snyder, S.H. (1994) Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity. Science, 263:687-689.
36. Zhang, Y., Marcillat, O., Giulivi, C., Ernster, L., and Davies, K.J.A. (1990) The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J. Biol. Chem., 265:16330-16336.