Nitric oxide synthase (NOS3) and contractile responsiveness to adrenergic and cholinergic agonists in the heart: Regulation of NOS3 transcription in vitro and in vivo by cyclic adenosine monophosphate in rat cardiac myocytes

Journal of Clinical Investigation

Volumn 97, Issue 8, 1996, Pages 1908-1915

  Belhassen, Laurent ^a   Kelly, Ralph A ^a   Smith, Thomas W ^a   Balligand, Jean Luc ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

3 5 cyclic nucleotide phosphodiesterase; Calcium; Cell culture; L arginine; Microvascular endothelial cells

Indexed keywords

CYCLIC AMP; NITRIC OXIDE SYNTHASE;

ADRENERGIC NERVE; ANIMAL CELL; ARTICLE; DOWN REGULATION; ENZYME ACTIVITY; HEART INNERVATION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSCRIPTION REGULATION; VASCULAR ENDOTHELIUM;

1-METHYL-3-ISOBUTYLXANTHINE; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; CARBACHOL; CELLS, CULTURED; CHOLINERGIC AGONISTS; CYCLIC AMP; ENDOTHELIUM, VASCULAR; FORSKOLIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART; ISOPROTERENOL; KINETICS; MALE; MILRINONE; MYOCARDIAL CONTRACTION; MYOCARDIUM; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE INHIBITORS; PYRIDONES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0029933241     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118622     Document Type: Article

References (30)

1. Bredt, D.S., P.M. Hwang, C.E. Glatt, C. Lowenstein, R.R. Reed, and S.H. Snyder 1991. Cloned and expressed nitric oxide synthase structurally iesembles cytochrome P-450 reductase Nature (Lond ) 351:714-718
2. Xie, Q.W , H.J. Cho, J. Calaycay, R.A Mumford, K.M. Swiderek, T D Lee, A. Ding, T. Troso, and C. Nathan 1992. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science (Wash. DC) 256:225-228.
3. Lamas, S., P.A. Marsden, G.K. Li, P. Tempst, and T. Michel, 1992 Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad. Sci USA 89:6348-6352
4. Balligand, J L , D. Ungureanu-Longrois, W.W. Simmons, D. Pimental, T.A. Malinski, M. Kapturczak, Z Taha, C.J. Lowenstein, A.J. Davidoff, R A Kelly, et al. 1994 Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J. Biol. Chem 269:27580-27588.
5. Balligand, J.L., L. Kobzik, X. Han, D.M. Kaye, L. Belhassen, D.S. O'Hara, R.A. Kelly, T.W Smith, and T. Michel. 1995. Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J. Biol. Chem. 270:14582-14586.
6. Balligand, J.L., R.A. Kelly. P.A Marsden, T.W. Smith, and T. Michel 1993, Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc. Natl. Acad. Sci. USA. 90:347-351.
7. Brady, A.J., J.B. Warren, P.A. Poole-Wilson, T.J. Williams, and S.E Harding. 1993. Nitric oxide attenuates cardiac myocyte contraction. Am. J. Physiol. 265:H176-H182.
8. Grocott-Mason, R , P. Anning, H. Evans, M.J. Lewis, and A.M. Shah. 1994, Modulation of left ventricular relaxation in isolated ejecting heart by endogenous nitric oxide. Am. J. Physiol 267:H1804-1813.
9. 2- current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation. J Biol. Chem. 26826286-26295.
10. Koide, M., Y. Kawahara, I. Nakayama, T. Tsuda, and M Yokoyama. 1993. Cyclic AMP-elevating agents induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells. Synergism with the induction elicited by inflammatory cytokines. J. Biol. Chem. 268:24959-24966.
11. Bredt, D.S., D.C. Ferris, and S.H. Snyder. 1992. Nitric oxide synthase regulatory sites: Phosphorylation by cAMP-dependent protein kinase, protein kinase C, calcium calmodulin protein kinase, identification of flavin and calmodulin binding sites. J. Biol. Chem. 267:10976-10981.
12. Nishida, K., D.G. Harrison, J.P. Navas, A.A. Fisher, S P. Dockery, M. Uematsu, R.M. Nerem, R.W. Alexander, and T.J. Murphy. 1992. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J. Clin Invest. 90.2092-2096.
13. Yoshizumi, M., P A. Perrella, J.C. Burnett, and M Lee 1993. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life Circ Res 73:205-209.
14. Marsden, P.A., H.Q.Q. Heng, S.W. Scherer, R.J Stewart, A.V. Hall, X.-M. Shi, L.-C. Tsui. and K.T. Scappert. 1993. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem 268:17478-17488.
15. Robinson, L.J., S. Wereinowicz, C.C. Morton, and T. Michel. 1994. Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene. Genomics. 19.350-357.
16. Zhang, R., W Min, and W.C. Sessa 1995. Functional analysis of the human endothelial nitric oxide synthase promoter Sp1 and GATA factors are necessary for basal transcription in endothelial cells. J. Biol. Chem. 270:15320-15326.
17. Berger, H.-J., S K Prasad, A.J. Davidoff, D. Pimentai, Ø. Ellingsen, J.D Marsh, T.W. Smith, and R.A. Kelly 1994. Continual electric field stimulation preserves contractile function of adult ventricular myocytes in primary cultures. Am. J. Physiol 266:H341-H349.
18. Sweet, C.S , C.T Ludden, I.I. Stabilito, S.E. Emmert, and J.F Heyse 1988. Beneficial effects of milrinone and enalapril on long-term survival of rats with healed myocardial infarction. Eur. J. Pharmacol. 147:29-37.
19. Nishida, M., W W. Carley, M.E. Gerritsen, Ø. Ellingsen, R.A. Kelly, and T.W. Smith. 1993. Isolation and characterization of human and rat cardiac microvascular endothehal cells. Am J. Physiol. 91:1934-1941.
20. Sambrook, J . E.F. Fritsch. and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 7.39-7.52.
21. Chomczynski, P., and N Sacchi. 1987. Single-step method of RNA isolation by acid guaninium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159
22. Han, X., Y. Shimoni, and W.R Gilles. 1994. An obligatory role for nitric oxide in autonomic control of mammalian heart-rate. J. Physiol. (Lond.). 476: 309-314.
23. Trautwein, W., A. Cavalie, T.J. Allen, Y.M. Shuba, S. Pelzer, and D. Pelzer. 1990. Direct and indirect regulation of cardiac L-type calcium channels by betaadrenoreceptor agonists. Adv. Second Messenger Phosphoprotein Res. 24:45-50.
24. Balligand, J.L., D. Ungureanu-Longrois, W W. Simmons, L. Kobzik, C.J. Lowenstein, S Lamas, R.A. Kelly, T.W. Smith, and T. Michel. 1995. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1β and IFN-γ. Am J Physiol 268.H1293-H12303
25. Manolopoulos, V G., M.M. Samet, and P.I Lelkes. 1995, Regulation of the adenylyl cyclase signaling system in various types of cultured endothelial cells. J. Cell. Biochem. 57:590-598.
26. Lalli, E., and P. Sassone-Corsi. 1994. Signal transduction and gene regulation: the nuclear response to cAMP. J. Biol. Chem. 269:17359-17362
27. Manganiello, V.C., C.J. Smith, E Degerman, and P. Belfrage, 1990. Cyclic GMP-inhibited cyclic nucleotide phosphodiesterases. In Cyclic Nucleotide Phosphodiesterases. Structure, Regulation and Drug Action. J.A. Beavo and M.D Housley, editors John Wiley and Sons Ltd., Chichester, UK 87-114.
28. Shahid, M., and C.D. Nicholson. 1990. Comparison of cyclic nucleotide phosphodiesterase isoenzymes m rat and rabbit ventricular myocardium: positive inotropoc and phosphodiesterase inhibitory effects of Org 30029, milrinone and rolipram. Naunyn-Schmiedeberg's Arch Pharmacol. 342:698-705.
29. Katano, Y., and M. Endoh. 1992. Effects of a cardiotonic quinolinone derivative Y-20487 on the isoproterenol-induced positive ionotropic action and cyclic AMP accumulation in rat ventricular myocardium: comparison with rolipram, Ro 201724, milrinone, and isobutylmethylxanthine. J. Cardiovasc. Pharmacol. 20.715-722.
30. Bode, D C., J.R Kanter, and L.L. Brunton, 1988. Resolution of soluble rat cardiac phosphodiesterases by high performance liquid chromatography. Second Messengers Phosphoproteins. 12:235-240.