Effects of chronic ethanol consumption and aging on dopamine, serotonin, and metabolites

Journal of Neurochemistry

Volumn 66, Issue 5, 1996, Pages 2168-2178

  Woods, James M ^a   Druse, Mary J ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Aging; Dopamine; Ethanol; Mesocorticolimbic system; Nigrostriatal area; Serotonin

Indexed keywords

DOPAMINE; DRUG METABOLITE; SEROTONIN;

AGING; ALCOHOL CONSUMPTION; ANIMAL TISSUE; ARTICLE; DOPAMINE METABOLISM; DOPAMINE UPTAKE; DOPAMINERGIC TRANSMISSION; DRUG EFFECT; MENTAL FUNCTION; MOTOR PERFORMANCE; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; TOTAL BODY WATER; VENTRAL TEGMENTUM;

EID: 0029933178     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66052168.x     Document Type: Article

References (106)

1. Aghajanian G. K., Rosecrans J. A., and Sheard M. H. (1967) Serotonin: release in the forebrain by stimulation of midbrain raphe. Science 156, 402-403.
2. Altar C. A. and Marshall J. F. (1988) Neostriatal dopamine uptake and reversal of age-related movement disorders with dopamine-uptake inhibitors. Ann. NY Acad. Sci 515, 343-354.
3. Arborelius L., Nomikos G. G., Hacksell U., and Svensson T. H. (1993) R-8-OH-DPAT preferentially increases dopamine release in rat medial prefrontal cortex. Acta Physiol. Scand. 148, 465-466.
4. Arranz B., Eriksson A., Mellerup E., Plenge P., and Marcusson J. (1993) Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. Brain Res. 620, 163-166.
5. Bacopoulos N. G., Bhatnagar R. K., and Van Orden L. S. (1978) The effects of subhypnotic doses of ethanol on regional catecholamine turnover. J. Pharmacol. Exp. Ther. 204, 1-10.
6. Benloucif S. and Galloway M. P. (1991) Facilitation of dopamine release in vivo by serotonin agonists: studies with microdialysis. Eur. J. Pharmacol. 200, 1-8.
7. Brodie M. S., Shefner S. A., and Dunwiddie T. V. (1990) Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res. 508, 65-69.
8. Brower K. J., Mudd S., Blow F. C., Young J. P., and Hill E. M. (1994) Severity and treatment of alcohol withdrawal in elderly versus younger patients. Alcohol. Clin. Exp, Res. 18, 196-201.
9. Caine S. B. and Koob G. F. (1993) Modulation of cocaine self-administration in the rat through D3 dopamine receptors. Science 260, 1814-1816.
10. Chen N.-H. and Reith M. E. A. (1995) Monoamine interactions measured by microdialysis in the ventral tegmental area of rats treated systemically with (±)-8-hydroxy-2-(di-n-propylamino)-tetralin. J. Neurochem. 64, 1585-1597.
11. Colsher R. L. and Wallace R. B. (1990) Elderly men with histories of heavy drinking: correlates and consequences. J. Stud. Alcohol 51, 528-535.
12. Cooper J. R., Bloom F. E., and Roth R. H. (1991) Dopamine, in The Biochemical Basis of Neuropharmacology, pp. 285-337. Oxford University Press, New York.
13. Darden J. H. and Hunt W. A. (1977) Reduction of striatal dopamine release during an ethanol withdrawal syndrome. J. Neurochem. 29, 1143-1145.
14. DeFranco C., Tarbox A. R., and McLaughlin E. J. (1985) Cognitive deficits as a function of years of alcohol abuse. Am. J. Drug Alcohol Abuse 11, 279-293.
15. Demarest K. T., Riegle G. D., and Moore K. E. (1980) Characteristics of dopaminergic neurons in the aged male rat. Neuroendocrinology 31, 222-227.
16. Di Chiara G. and Imperato A. (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesohmbic system of freely moving rats. Proc. Natl. Acad. Sci. USA 85, 5274-5278.
17. Diana M., Gessa G. L., and Rossetti Z. L. (1992) Lack of tolerance to ethanol-induced stimulation of the mesolimbic dopamine system. Alcohol 27, 329-333.
18. Egbert A. M. (1993) The older alcoholic: recognizing the subtle clinical clues. Geriatrics 48, 63-69.
19. Fadda F., Argiolas A., Melis M. R., Serra G., and Gessa G. L. (1980) Differential effects of acute and chronic ethanol on dopamine metabolism in frontal cortex, caudate nucleus, and substantia nigra. Life Sci. 27, 979-986.
20. Fibiger H. C. and Miller J. J. (1977) An anatomical and electrophysiological investigation of the serotonergic projection from the dorsal raphe nucleus to the substantia nigra in the rat. Neuroscience 2, 975-987.
21. Finch C. E. (1973) Catecholamine metabolism in the brains of aging male mice. Brain Res. 52, 261-276.
22. Freund G. (1984) Neurotransmitter function in relation to aging and alcoholism, in Alcoholism in the Elderly (Hartford J. T. and Samorajski T., eds), pp. 65-83. Raven Press, New York.
23. Gessa G. L., Muntoni F., Collu M., Vargiu L., and Mereu G. (1985) Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res. 348, 201-203.
24. Giambalvo C. T. and Snodgrass S. T. (1978) Biochemical and behavioral effects of serotonin neurotoxins on the nigro-striatal dopamine system: comparison of injection sites. Brain Res. 152, 555-566.
25. Godefroy F , Bassant M. H., Weil-Fugazza J., and Lamour Y. (1989) Age-related changes in dopaminergic and serotoninergic indices in the rat forebrain. Neurobiol. Aging 10, 187-190.
26. Gozlan H., Daval G., Verge D., Spampinato U., Fattaccini C. M., Gallissot M. C., El Mestikawy S., and Hamon M. (1990) Aging associated changes in serotoninergic and dopaminergic pre- and postsynaptic neurochemical markers in the rat brain. Neurobiol. Aging 11, 437-449.
27. Gupta K. L. (1993) Alcoholism in the elderly: uncovering a hidden problem. Alcoholism 93, 203-206.
28. Hamdi A. and Prasad C. (1993) Bidirectional changes in striatal D2-dopamine receptor density during chronic ethanol intake. Alcohol 9, 133-137.
29. Hayakawa K., Kumagai H., Suzuki Y., Furusawa N., Haga T., Hoshi T., Fujiwara Y., and Yamaguchi K. (1992) MRI imaging of chronic alcoholism. Acta Radiol. 33, 201-206.
30. Hietala J., Salonen I., Lappalainen J., and Syvalahti E. (1990) Ethanol administration does not alter dopamine D1 and D2 receptor characteristics in rat brain. Neurosci. Lett. 108, 289-294.
31. Hodge C. W., Haraguchi M., Erickson H., and Samson H. H. (1993) Ventral tegmental microinjections of quinpirole decrease ethanol and sucrose-reinforced responding. Alcohol. Clin. Exp. Res. 17, 370-375.
32. Hortnagl H., Potter P. E., Kindel G., and Hanin I. (1989) Noradrenaline depletion protects cholinergic neurons in rat hippocampus against AF64A-induced damage. J. Neurosci. Methods 27, 103-108.
33. 2 dopamine receptors. J. Neurochem. 50, 1929-1933.
34. Hunt W. A. (1985) Neuroreceptors, in Alcohol and Biological Membranes (Wilsnack S. E. and Beckman L. J., eds), pp. 103-110. Guilford Press, New York.
35. Hunt W. A. and Dalton T. K. (1981) Neurotransmitter-receptor binding in various brain regions in ethanol-dependent rats. Pharmacol. Biochem. Behav. 14, 733-739.
36. Hunt W. A. and Majchrowicz E. (1983) Studies of neurotransmitter interactions after acute and chronic ethanol administration. Pharmacol. Biochem Behav. 18, 371-374.
37. Imperato A. and Angelucci L. (1989) 5-HT3 receptors control dopamine release in the nucleus accumbens of freely moving rats. Neurosci. Lett. 101, 214-217.
38. Imperato A. and Di Chiara G. (1986) Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J. Pharmacol. Exp. Ther. 239, 219-228.
39. Irwin I., DeLanney L. E., McNeill T., Chan P., Forno L. S., Murphy G. M., Di Monte D. A., Sandy M. S., and Langston J. W. (1994) Aging and the nigrostriatal dopamine system: a non-human primate study. Neurodegeneration 3, 251-265.
40. Khatib S. A., Murphy J. M., and McBride W. J. (1988) Biochemical evidence for activation of specific monoamine pathways by ethanol. Alcohol 5, 295-299.
41. Kish S. J., Shannak K., Rajput A., Deck J H. N., and Hornykiewicz O. (1992) Aging produces a specific pattern of striatal dopamine loss: implications for the etiology of idiopathic Parkinson's disease. J. Neurochem. 58, 642-648.
42. Koob G. F. (1992) Neural mechanisms of drug reinforcement. Ann. NY Acad. Sci. 654, 171-191.
43. Koob G. F. and Weiss F. (1990) Pharmacology of drug self-administration. Alcohol 7, 193-197.
44. Koob G. F., Rassnick S., Heinrichs S., and Weiss F. (1994) Alcohol, the reward system and dependence. EXS 71, 103-114.
45. Laurier L. G., Corrigall W. A., and George S. R. (1994) Dopamine receptor density, sensitivity and mRNA levels are altered following self-administration of cocaine in the rat. Brain Res. 634, 31-40.
46. Lee J. M., Ross E. R., Gower A., Paris J. M., Martensson R., and Lorens S. A. (1994) Spatial learning deficits in the aged rat: neuroanatomical and neurochemical correlates. Brain Res. Bull. 33, 489-500.
47. Lewis M. J. and June H. L. (1990) Neurobehavioral studies of ethanol reward and activation. Alcohol 7, 213-219.
48. Liberto J. G., Oslin D. W., and Ruskin P E. (1992) Alcoholism in older persons: a review of the literature. Hosp. Community Psychiatry 43, 975-984.
49. Lograno D. E., Matteo F., Trabucchi M., Govoni S., Cagiano R., Lacomba C., and Cuomo V. (1993) Effects of chronic ethanol intake at a low dose on the rat brain dopaminergic system. Alcohol 10, 45-49.
50. Lorens S. A., Hata N., Handa R. J., Van de Kar L. D., Guschwan M.. Goral J., Lee J. M., Hamilton M. E., Bethea C. L., and Clancy J. (1990) Neurochemical, endocrine and immunological responses to stress in young and old Fischer 344 male rats. Neurobiol. Aging 11, 139-150.
51. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol Chem. 193, 265-275.
52. Lucchi L., Moresco R. M., Govoni S., and Trabucchi M. (1988) Effect of chronic ethanol treatment on dopamine receptor subtypes in rat striatum. Brain Res. 449, 347-351.
53. Marshall J. F. and Berrios N. (1979) Movement disorders of aged rats: reversal by dopamine receptor stimulation. Science 206, 477-479.
54. May T. (1992) Striatal dopamine D1-like receptors have higher affinity for dopamine in ethanol-treated rats. Eur. J. Pharmacol. 215, 313-316.
55. McBride W. J., Murphy J. M., Lumeng L., and Li T. K. (1990) Serotonin, dopamine, and GABA involvement in alcohol drinking of selectively bred rats. Alcohol 7, 199-205.
56. McEntee W. J. and Crook T. H. (1991) Serotonin, memory, and the aging brain. Psychopharmacology (Berlin) 103, 143-149.
57. McGeer P. L., McGeer E. G., and Suzuki J. S. (1977) Aging and extrapyramidal function. Arch. Neurol. 34, 33-35.
58. Meyer J. S., Largen J. W., Shaw T., Mortel K. F., and Rogers R. (1984) Interactions of normal aging, senile dementia, multiinfarct dementia, and alcoholism in the elderly, in Alcoholism in the Elderly (Hartford J. T. and Samorajski T., eds), pp. 227-251. Raven Press, New York.
59. Morelli M., Mennini T., Cagnotto A., Toffano G., and Di Chiara G. (1990) Quantitative autoradiographic analysis of the age-related modulation of central dopamine D1 arid D2 receptors. Neuroscience 36, 403-410.
60. Moretti A., Carfagna N., and Trunzo F. (1987) Effect of aging on monoamines and their metabolites in the rat brain. Neurochem. Res. 12, 1035-1039.
61. Morgan D. and Finch C. (1988) Dopaminergic changes in the basal ganglia: a generalized phenomenon of aging in mammals. Ann. NY Acad. Sci. 515, 213-228.
62. Morgan D. G., May P. C., and Finch C. E. (1987) Dopamine and serotonin systems in human and rodent brain: effects of age and neurodegenerative disease. J. Am. Geriatr. Soc. 35, 334-345.
63. Naranjo C. A. and Bremner K. E. (1994) Serotonin-altering medications and desire, consumption and effects of alcohol-treatment implications. EXS 71, 209-219.
64. Naranjo C. A , Poulos C. X., Bremner K. E., and Lanctot K. L (1992) Citalopram decreases desirability, liking, and consumption of alcohol in alcohol-dependent drinkers. Clin. Pharmacol. Ther. 51, 729-739.
65. Noonberg A., Goldstein G., and Page H A. (1985) Premature aging in male alcoholics: "accelerated aging" or "increased vulnerability"? Alcohol. Clin. Exp. Res. 9, 334-338.
66. Noronha A B. and Druse M. J. (1982) Maternal ethanol consumption and synaptic membrane glycoproteins in offspring. J. Neurosci. Res. 8, 83-97.
67. Olpe H. R. and Koella W P. (1977) The responses of striatal cells upon stimulation of the dorsal and median raphe nuclei. Brain Res. 122, 357-360.
68. Palkovits M. and Brownstein M. J. (1988) Maps and Guide to Microdissection of the Rat Brain. Elsevier Press, New York.
69. Panocka I. and Massi M. (1992) Long-lasting suppression of alcohol preference in rats following serotonin receptor blockade by ritanserin. Brain Res. Bull. 28, 493-496.
70. Panocka I., Ciccocioppo R., Polidori C., and Massi M. (1993) The nucleus accumbens is a site of action for the inhibitory effect of ritanserin on ethanol intake in rats. Pharmacol. Biochem. Behav. 46, 857-862.
71. Parker E. S., Parker D. A., Brody J. A., and Schoenberg R. (1982) Cognitive patterns resembling premature aging in male social drinkers. Alcohol. Clin. Exp. Res. 6, 46-52.
72. Pasini A., Tortorella A., and Gale K. (1992) Anticonvulsant effect of intranigral fluoxetine. Brain Res. 593, 287-290.
73. Pellegrino S. M. and Druse M. J. (1992) The effects of chronic ethanol consumption on the mesolimbic and nigrostriatal dopamine systems. Alcohol. Clin. Exp. Res. 16, 275-280.
74. Pfefferbaum A., Lim K. O., Zipursky R. B., Mathaton D. H., Rosenbloom M J., Lane B., Ha C. N., and Sullivan E. (1992) Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study. Alcohol. Clin. Exp. Res. 16, 1078-1089.
75. Ponzio F., Calderini G., Lomuscio G., Vantini G., Toffano G., and Algeri S. (1982) Changes in monoamines and their metabolite levels in some brain regions of aged rats. Neurobiol. Aging 3, 23-29.
76. Ponzio F., Achilli G., Calderini G., Ferretti P., Perego C., Toffano G., and Algeri S. (1984) Depletion and recovery of neuronal monoamine storage in rats of different ages treated with reserpine. Neurobiol. Aging 5, 101-104.
77. Pradhan S. N. (1980) Central neurotransmitters and aging. Life Sci. 26, 1643-1656.
78. Prisco S., Pagannone S., and Esposito E. (1994) Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo. J. Pharmacol. Exp. Ther. 271, 83-90.
79. Rabin R. A , Wolfe B. B., Dibner M. D , Zahniser N. R., Melchior C., and Molinoff P. B. (1980) Effects of ethanol administration and withdrawal on neurotransmitter receptor systems in C57 mice. J. Pharmacol. Exp. Ther. 213, 491-496.
80. Robson L., Gower A. J., Kendall D. A., and Marsden C. A. (1993) Age-related behavioural, neurochemical and radioligand binding changes in the central 5-HT system of Sprague-Dawley rats. Psychopharmacology (Berlin) 113, 274-281.
81. Rosetti Z L., Hmaidan Y., Diana M., and Gessa G. L. (1993) Lack of tolerance to ethanol-induced dopamine release in rat ventral striatum. Eur. J. Pharmacol. 231, 203-207.
82. Roth G. S. (1982) Altered mechanisms of opiate and dopaminergic action during aging, in The Aging Brain: Cellular and Molecular Mechanisms of Aging in the Nervous System (Giacobini E., ed), pp. 203-209. Raven Press, New York.
83. Ryan C. (1982) Alcoholism and premature aging: a neuropsychological perspective. Alcohol. Clin. Exp. Res. 6, 22-30.
84. Ryan C. and Butters N. (1980) Learning and memory impairments in young and old alcoholics: evidence for the premature-aging hypothesis. Alcohol. Clin. Exp. Res. 4, 288-293.
85. Ryan C. and Butters N. (1984) Alcohol consumption and premature aging a critical review. Recent Dev. Alcohol. 2, 223-250.
86. Samorajski T., Persson K., Bissell C., Brizzee L., Lancaster F., and Brizzee K. R. (1984) Biology of alcoholism and aging in rodents: brain and liver, in Alcoholism in the Elderly (Hartford J T. and Samorajski T., eds), pp. 43-63 Raven Press, New York.
87. Samson H. H., Tolliver G. A., and Schwartz-Stevens K. (1990) Oral ethanol self-administration: a behavioral pharmacological approach to CNS control mechanisms. Alcohol 7, 187-191.
88. Samson H. H., Tolliver G. A , Haraguchi M , and Hodge C. W. (1992) Alcohol self-administration: role of mesolimbic dopamine. Ann. NY Acad. Sci. 654, 242-253.
89. Schwartz J. C., Diaz J., Griffon N., Levesque D., Martres M. P., and Sokoloff P. (1994) Multiple dopamine receptors: the D3 receptor and actions of substances of abuse. EXS 71, 81-92.
90. Singh G. K., Kalmus G. W., Bjork A. K., and Myers R D. (1993) Alcohol drinking in rats is attenuated by the mixed 5-HT1 agonist/5-HT2 antagonist FG 5893. Alcohol 10, 243-248.
91. Sivam S. P. (1995) Dopaminergic modulation of serotonin metabolism in rat striatum: a study with dopamine uptake inhibitor GBR-12909. Life Sci. 56, 467-472.
92. Smart R. G and Adlaf E. M. (1988) Alcohol and drug use among the elderly: trends in use and characteristics of users. Can. J. Public Health 79, 236-242.
93. Steinbusch H. W. M. (1981) Distribution of serotonin-immunoreactivity in the central nervous system in the rat cell bodies and terminals. Neuroscience 6, 557-618.
94. Strong R., Samorajski T., and Gottesfeld Z. (1982) Regional mapping of neostriatal neurotransmitter systems as a function of aging. J. Neurochem. 39, 831-836.
95. Tabakoff B. and Hoffman P. L. (1979) Development of functional dependence on ethanol in dopaminergic systems. J. Pharmacol. Exp. Ther. 208, 216-222.
96. 2 receptors in Fischer 344 rats. Alcohol. Clin. Exp. Res. (in press).
97. Van Luijtelaar M. G., Tonnaer J. A., and Steinbusch H. W. (1992) Aging of the serotonergic system in the rat forebrain: an immunocytochemical and neurochemical study. Neurobiol. Aging 13, 201-215
98. Venero J. L., de la Roza C., Machado A., and Cano J. (1993) Age-related changes on monoamine turnover in hippocampus of rats. Brain Res. 631, 89-96.
99. Walker D. W., Barnes D. E., Zornetzer S. F., Hunter B. E., and Kubanis P. (1980) Neuronal loss in hippocampus induced by prolonged ethanol consumption in rats. Science 209, 711-713.
100. Wood W. G. and Armbrecht H. J. (1982) Behavioral effects of ethanol in animals: age differences and age changes. Alcohol. Clin. Exp. Res. 6, 3-12.
101. Woods J. M., Ricken J., and Druse M. J. (1995) Effects of chronic alcohol consumption and aging on dopamine D1 receptors in Fischer 344 rats. Alcohol. Clin. Exp. Res. 19, 1331-1337.
102. Wozniak K. M., Pert A., and Linnoila M. (1990) Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine. Eur. J. Pharmacol. 187, 287-289.
103. Yadid G., Pacak K., Kopin I. J., and Goldstein D. S. (1994) Endogenous serotonin stimulates striatal dopamine release in conscious rats. J. Pharmacol. Exp. Ther. 270, 1158-1165.
104. Yoshimoto K., McBride W. J., Lumeng L., and Li T. K. (1992a) Ethanol enhances the release of dopamine and serotonin in the nucleus accumbens of HAD and LAD lines of rats. Alcohol. Clin. Exp. Res. 16, 781-785.
105. Yoshimoto K., McBride W. J , Lumeng L., and Li T. K. (1992b) Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens. Alcohol 9, 17-22.
106. Zigmond R. E., Schwarzschild M. A., and Rittenhouse A. R. (1989) Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation. Annu. Rev. Neurosci. 12, 415-461.